American Dragon: Jake Long/Tear Jerker

"Rose: [about to be killed by the skulls' power] Thank you Jake! For everything! I'll never forget you!
 * The flashback sequence at the end of "Ski Trip".
 * Rose's attempted Heroic Sacrifice.

Jake: Rose, no!

Rose: Jake, let go. I'll be okay. I promise. I'll be okay."


 * How about I add to that. Jake intervenes to stop Rose from being killed with the rest of the Huntsclan, but they all vanish just the same, so it's impossible to tell if he was successful.
 * Jake wishing that Rose was never taken by the Huntsclan, and could just have a normal life. The sheer amount of heartbreak in his voice is enough to make the tears come.
 * And later in the episode, where he finds that this is the case. She doesn't remember who he is, but he asks if they could meet again. She says they can't, because she's moving to Hong Kong. Rather bittersweet, really.