Who Framed Roger Rabbit?/WMG

Human-toon interbreeding backstage is the reason CGI films are getting better and better.
In the beginning, there were human humans and hand-drawn-looking Toons, and never the twain did meet. But then one day, someone got curious, and the result was something oddly in-between -- a CGI Toon. As this has become more common (and social attitudes have become more egalitarian), it's got to the stage where CGI toons can get cast as stuntmen and props alongside human actors without people batting an eyelid - and now they're even taking starring roles. In fact, Hollywood may be approaching an extended CGI-spolitation period. In thirty years' time, Toy Story may well be viewed as this generation's Shaft.
 * This theory may also be an explanation for Robin Williams and Jim Carrey.
 * This can work in the opposite direction too, i.e. toons who act entirely like regular people. For example, the cast of Daria who display no supernatural powers whatsoever.
 * Judge Doom may have been one of the first.
 * Human-toon inbreeding can also explain why so many toons resemble famous human actors and performers. After all, the first humans to come in regular contact with toons would be people who were spending a lot of time in Hollywood or in TV studios. Indeed, hundreds of toons trace ancestry back to greats like Elvis Presley, Peter Lorre, Frank Sinatra, and the like.

Judge Doom did not invent the Dip
Toons are physically indestructible and have an enormous variety of wacky powers at their disposal, and yet they're an oppressed minority subservient to humans. How can this be? Well, Judge Doom did not invent the Dip. The substance had been present for many years previously and used by fearful humans in power to prevent the toons from using their advantages to rule over humanity. All the judge did was bring the Dip to the human public's attention. Toons had always lived in fear of it.
 * Toons don't need Dip to be kept under control. Toons need to be famous or else they fade away. Toons need to be on film or broadcast like humans need food and water, so every toon is an actor and they have no choice of other occupations. Taking over the world wouldn't be a practical alternative. On the other hand, it must have been common knowledge that toons could be harmed by things which dissolve paint. There was nothing revolutionary about Dip; it was just a highly effective mix.
 * One problem with this hypothesis: Acting is not the only way to get on the toons. Another is politics. If you take over the world, you get broadcast on Fox Noise Channel and Most Socialist Network on Basic Cable multiple times a day. Now you start to see the motivation of Brain.
 * Plus, wasn't Doom himself a toon? How was he "feeding"? And furthermore, how does it logically follow that Dip works by dissolving paint? That's a Voodoo Shark if ever I heard one.
 * Or maybe Dip was invented by aliens.

Toons are a historically oppressed minority
When Eddie Valiant walks into the Terminal Station Bar to speak to Dolores, there is an African American patron drinking there as well as several Caucasian patrons. In our 1947, racism was sadly the norm, and he may not have been allowed into a possibly "white-only" bar. However, there's nary a toon sitting alongside the humans, implying that this is a human-only bar. This implies that the alternate world of WFRR is a Crapsack World full of Fantastic Racism where black and white have ganged up on green.
 * This WMG in general is true in the book.
 * Word of God confirms this WMG for the movie.
 * And yet, it's never shown that the regulars in the bar wouldn't welcome toon patrons, as evident in Roger's rendition of "The Merry-Go-Round Broke Down".

Human bars don't normally allow Toons as customers because Toons can't handle human liquor.
Toons are naturally comical, childish, and silly. When Valiant gave Roger liquor, Roger became uncontrollable and was literally bouncing off the walls. This took very little alcohol. If all toons share a similar tolerance, then no sane human bar would allow them.
 * Case in point: Bender Rodriguez.
 * This also could be because the Toons are made of paint and ink, alcohol disrupts their system.

The toons eventually faded away
Being too different, humans and toons parted ways, each one living in a world of their own, separate from the other. However, the legacy of human studio heads making cartoons led to the myth that humans created the toons, when in reality both species exist independently. By the time their alternate timeline rolled around to 1992, interaction between the human and toon worlds was not only extremely rare, but exceedingly dangerous as well...

CGI characters are toon / human hybrids
...well, doesn't it make a twisted sort of sense?
 * Yes. And after a certain point, at least in this country, hybrids started outnumbering the purebred toons.
 * Well, looks like you've given someone an idea. :D
 * This breeding has damaged the Toons: now, even when it's Toon/Toon, the offspring looks far more caricature-ish and not like the animation of the old days.

Toon Town is part of Traverse Town.
Certainly would explain all the Disney characters.
 * All Disney worlds are part of the Kingdom Hearts universe. That is what Toontown is: another world in the Kingdom Hearts universe.
 * But Kingdom Hearts represents the Disney cartoons as being real and living in different worlds; Who Framed Roger Rabbit represents them as being actors and actresses along with all other Toons, sharing the same world. These depictions cannot be reconciled without either acknowledging the KH world as fundamentally "false" or putting alternate realities into play...
 * Kingdom Hearts is about alternate realities. Disney has addressed the other aspect in some of its other works: classic Disney toons are Animated Actors, but they usually are just like the characters they play. (Disney is attempting this with much of its live-action line-up as well.)

Doom is an artificial Toon created by one of the companies involved in the highway project.
Doom seems to be randomly assembled from different cartoon objects, & parts of him appear organic. He may even have been created by weird Nazi mad science experiments; many big American companies did business with Nazis and got away with it.

Judge Doom is half-human
In the comic book series / graphic novel The Resurrection of Doom, it is revealed that he was Baron von Rotten, a guy who played the villain in certain cartoons, who one day suffered a head injury and woke up believing that he really was the character he played. (It would be like Baby Herman being under the delusion that he's truly a baby). RK Maroon explains that no matter how badly injured toons are, they can just shake it off. Therefore, Doom can't bee 100% toon and may be a Half-Human Hybrid.
 * It could be a Fred Flintstone situation, getting bonked on the head and thinking he's different person. Or was Fred just following a script for those cartoons, and in real life Fred can take heavy objects to the head without incident? (Or is Fred half-human as well?)
 * Probably the first one.
 * If you count licensed comics as canon, the "Fred Flintstone" situation is actually confirmed in a comic book sequel to the movie. According to the comic, Judge Doom was originally a Toon actor specializing in bad-guy roles, who was known for his versatile range and played many one-shot bad guys in cartoons for different studios. Until he got bonked on the head and started thinking he was a villain in real life too.
 * As Baron von Rotten, he may have taken his villainous roles more seriously than the more comic toons, and began getting tired of being something merely to laugh at. Notice that as Judge Doom he has only disdain for the way most toons behave, in (to him) total disrespect of the law. The plan of dissolving all Toontown is his way of getting back at them for not taking him seriously. Being hit on the head didn't so much make him believe he was a real villain as more push him fully into what he was already becoming.
 * As a (presumed) human, Judge Doom commanded some real respect, much more so than any toon, even the most famous; after the blow he seems to switch allegiance from his toon to his human side.
 * No doubt there have been evil toons, but none seem to ever have thought of passing themselves off as human.

ALL 30s/40s/50s toons live in Toontown
The movie does take place in 1947, and so a lot of cartoon characters may have not been "born" yet.
 * But there are a lot of 50s cartoon characters IN THE MOVIE.
 * The humans don't create the toons. The toons are just a repressed minority with a culture based on showmanship and Rule of Funny. (Jessica's "I'm not bad, I'm just drawn that way" is a pun, a play on words.) The toons that haven't appeared in any cartoons before 1947 but became famous afterwards have just not gotten their start in Hollywood yet.
 * So were Peter Griffin and Homer Simpson (or for that matter, Fred Flintstone, debuted 1960) somewhere in the background or not born yet? How long do toons usually live?
 * Toons are potentially immortal, barring Dip. This is canon in the Warner Brothers verse -- a toon can live and be young as long as people remember him or her. It is probably true in at least some layers of the Disney-verse. Fred Flintstone is alive, but -- well, limited-animation toons like him were doubly despised before the freeways were built... which is why people making TV shows hired them.
 * Hmm, tricky. This contradicts a line spoken by Baby Herman in Who Censored Roger Rabbit? (Literature)? that goes something like, "What most people fail to realize is that some Toons age and some don't," as a way of justifying why he's matured mentally, but physically he's still an infant. Then, in Who Plugged Roger Rabbit? Roger reveals (to Clark Gable, no less) that in Toon communities it's considered extremely poor manners to ask someone's age (in fact, it's one of the two questions you should never ask a Toon, the other one being "what's the other one?")
 * If there was a third question, it would be "why'd ya bring that up at all?"
 * That's not a contradiction. The toons that age that he was talking about are the ones who grow older to make themselves fit the roles that they need to play. In other words, aging for toons is fake, little more than makeup. Baby Herman is just grumpy because he wishes he could work in a soap opera so he wouldn't have to look like a baby all the time. Because he would experience Soap Opera Rapid Aging Syndrome.

Judge Doom is a rogue Demon Weapon
This would explain how he's able to turn his hands into all sorts of blades. Plus, it could be that in destroying Toontown, he was planning to absorb the Toon souls and the mad zaniness of the place to become a Kishin, like a madder version of Masamune.

Jessica Rabbit is a loli Pettanko under the effects of a potion.
Blame the one who came up with a certain pic.
 * Wait, she was hit with a Fountain of Age? That's cruel...

Jessica Rabbit isn't, or at least didn't start out as, a Toon.
She's a a Doodle. Cool World is the sister land to Toon Town, for all the ADULT "toons." Jessica was born/created there; she decided she didn't like it and moved to Toon Town. Since she's too risque to get into regular cartoons designed to be seen by family-friendly audiences, she had to take the job at the Ink and Paint to help pay the bills. (Can't you see Jessica starting out as a "adult cartoon" actress?)
 * At least 34 people on the internet do.
 * That's not too far from how it was in the book.

Jessica Rabbit is a Furry
No amount of "He makes me laugh" can explain away the fact that she could have had any man or toon she wanted. Instead, she married a rabbit.
 * Roger is a pin-up by toon standards. And they are cartoons; they don't seem to have breeds.
 * The planned, but never made, prequel actually goes into Roger and Jessica's relationship a lot more. She was doing a sleazy nightclub act when she first met Roger, and was incredibly miserable. Roger was the first person to ever make her laugh.

The Pasadena Freeway (and its ilk) did help bring down the Toons.
The mass-market availability of TV and antitrust legislation are often named as the causes of the decline of the old studio system that fed theatrical cartoons. But the construction of new suburbs, new roads, and new movie theaters added to the specific problem with cartoons. When towns were compact, people more-or-less randomly walked into a downtown theater and watched the bill of fare until it started repeating stuff they had just seen ("Here's where I came in"). Maybe they'd check to see when the main attraction started so they wouldn't show up in the middle of it; but it was no big deal if they saw the cartoon, newsreel and so on before or after it. Once it became a matter of driving to a suburban theater, it was much more of a project (the theaters could be some distance from the residential areas), and so people just stayed for the main feature. Eventually, theaters just showed that...

Dip destroys a toon down to their soul

 * Even laughing to death doesn't kill a toon - Psycho was still dangerous when he was a ghost, and Wheezy almost managed to save himself by dragging his 'soul' back into his body. The four weasels who laughed themselves to death were merely temporarily incapacitated. But Dip even destroys the Ghosts of Toons.

Judge Doom was created by Teddy Valiant.
Teddy created Doom to combat a near-nonexistent case load. This, combined with Teddy teaching Doom about criminology and police procedures, would allow the Valiants to always have at least one case on which to work; Doom would be a formidable opponent who would probably never be caught. This explains why the guy just showed up.

Unfortunately, Doom grew tired of being hounded by his creator and killed him, giving him the freedom to do whatever he wanted without Teddy setting up the crimes for him.

Anime characters are similar to Toons, and have a similar universe.
They're a separate but closely related species. They can be killed like Western toons, but at the same time possess much more physical strength. Many are also much more Genre Savvy, which they often use to their advantage in combat. The anime version of Toontown, Anime-cho, can be accessed via a tunnel off a side street in Akihabara. (It is believed that the area at one point had poor lighting, creating the need to evolve large eyes, and solar flares from their currently bright sun may have led to the development of multi-colored hair.) Investigations are still being conducted as to whether there is a direct connection between Toontown and Anime-cho.
 * While I've no doubt that anime characters also exist in the world of Who Framed Roger Rabbit, I don't think some of your descriptions are spot-on. Do they possess more physical strength as a rule? Surely you haven't forgotten about Superman and Popeye! As for the Genre Savvy-ness, the Looney Tunes and others like them constantly break the fourth wall and use animation tropes to their advantage. And wouldn't they be more of a race than a different species, the same way there are some genetic difference between Asians and Westerners but both are still human?
 * Yeah, you've gotten it more correct there. I kinda wrote that on the fly and didn't take the, ahem, Unfortunate Implications into account there.
 * Well considering the movie takes place in the 40s Anime-cho might actually be the toon equivalent to an internment camp for Japanese Americans during WWII.
 * The japanese Toontown is better known as Chibi-cho, for the sake of having an Alliterative Name. Furthermore, the real Super-Deformed state of an anime character is actually the serious one, as demonstrated in the Fullmetal Alchemist ova "Chibi Party".
 * How about the different Face Faults? Can you explain that?
 * Face Faults are no different than the bug eyes, or gigantic mouths, or wild takes Western cartoons are able to do in the movie. Meaning, there IS no explanation.
 * Maybe there's also an alley off main Toontown that's a dwelling of anime characters travelled FROM Japan. That would explain why they've only acted in English relatively recently. Many toons disliked them and they returned the sentiment, only warming up over time--which may have led to toon/anime hybrids in a similar guess. Now it may be hard to distinguish them, like maybe Robin from Teen Titans is the son of the toon who played Batman in Batman the Animated Seriesand a somewhat-realistic anime character such as the anime girl who played Sato from Detective Conan.

Same goes for CGI, Claymation, and Muppet characters
There are connections between Toontown, Anime Cho, CG vill, Clayyvolk, and Mupp's Creek.
 * Other towns include Serkis Point, Sovietus, Flasidiak And Rotorian.
 * So CGI characters aren't Toon / Human hybrids, after all?
 * This makes a lot of sense for Muppets. It's never stated outright in a muppet movie, but humans seems to have the same social prejudice against them that they do against Toons. In The Muppet Christmas Carol, the lower class is nothing but muppets. In The Great Muppet Caper, the run-down Happiness Hotel is the only place shown to house them.

The creation of the freeway was a massive Xanatos Gambit set up by Japan in order for Anime to supplant Western Animation styles.
Angered at the American actions during WWII, a conglomerate of Japanese businesses set out to take over one of the great joys of American life: cartoons. Creating Cloverleaf Industries as a dummy company, this group employed Doom as their frontman and created DIP to ensure the creation of the freeway and the death of all Toons as they manipulated events from the background. Not only would they receive money for the freeway, but the eventual insinuation of anime into America would also cause Japan to gain a stranglehold on the American entertainment market.
 * What!? First of all Anime wasn't all that common in the 40's, the most Japan had animated where WWII propaganda films. So if there where toons in Japan the government clearly didn't have much interest in them and wouldn't waste time with it (besides they did have a "war" going on.) Second; post WWII Japan got many American imports one of which where films, and many animators (or directors in this world) where "inspired" by many western toon (Snow White and The Seven Dwarfs, Oswald the Lucky Rabbit, ect.) and later incorporated some of that style in the 60's. So by that anime characters would look up to toons as idols, and wouldn't dream of killing them because without them they probably wouldn't have gotten that far... or exist... or something.

This movie and Looney Tunes Back in Action take place in the same universe.
At least somewhat probable, since Shaggy and Scooby, two non-Looney Tunes characters, appear in the film.
 * And Bugs found Nemo.
 * It's just that we never get to visit Toon Town in that film, and because of it taking place in the present day instead of the 1940's, the toons have developed the ability to warp real world reality by now (i. e.- a car that doesn't fall from the sky until you're aware of it cannot do that if Bugs and Daffy were not in it, Bugs can transition locations of a scenes by turning the frame over, etc).
 * Steve Martin's Acme Head is a disguised Toon, just like Judge Doom.
 * Though that wouldn't explain why he became a live-action monkey.

The races of animated people are as follows:

 * Toons: Mostly originating in America. One of only four species of naturally occurring toons.
 * Flatties: Comic strip and comic book characters. They are less animated than Toons and move jerkily from one position to the next and are "flatter" and have less substance than Toons. If one becomes popular enough they can eventually become a Toon (sort of making a successful leap from theater to films).
 * Animane: Mostly hailing from Japan or Russia, the Animane rarely breed with the toons. When they do, the results are unpredictable.
 * The toons of Avatar: The Last Airbender turned out great.
 * CGI-lings (aka People of Data): The result of the unthinkable - sex between humans and Toons.
 * Claymen: Despite living for the most part in America (and England), these are Human-Animane crossbreeds.
 * Muppetoids: Utterly unrelated alien beings in the same universe. In a subversion of common tropes, and in a step forward for reality, they cannot reproduce with humans. Or Animane. Or Toons. They do have a symbiotic or parasitic relation with humans, though, and CAN breed with flatties, however this results in Gender Equals Breed rather than hybrids.
 * Note: The cast of Robot Chicken and Titan Maximum are claymen.
 * Having Claymen and Muppetoids be alive opens more questions than it answers.
 * Is any form of animation in this world just "the impression of life" rather than actual life? Or will shadow puppets achieve self-awareness?
 * Shadow puppets having self-awareness is silly. But it would be a shame if Wallace and Gromit or Jack Skellington didn't exist somewhere in this 'verse.
 * They are claymen.
 * NPCs and Video Game Physics, in that sense, would logically be the future versions animated toons. Everything runs on Nonsensoleum and giant brawls are common place.
 * Modern videogames with high budgets enough to make separate CGI cut scenes are a haven for CGI-lings. You could see true Toons in the arcade vs. of Dragons Lair, as well as Sonic CD and Sonic Riders.
 * I was also talking about old school Pixel characters, like Mario and placeholder Kirby.
 * What about Flash cartoons? And things made on Pivot? And realistic Serkis Folk in live action? And the paper cut outs from Blues Clues? The people from shows like Robot Chicken?
 * Flash characters are toons, Serkis Folk characters are CGI-lings, Robot Chicken characters are claymen, Eastern European Animation characters are toons. The rest I have no answer for.

Crossover Toons
In the books, there's something called "crossing over," meaning that some Toons look so much like humans that they could pass for human. In fact, in the original novel (which is not part of the WFRR continuity), Jessica was noted to be one. In the newer works, famous movie stars like Buster Keaton and The Three Stooges have been confirmed to be this. Which modern famous people stars do you suppose may be keeping a little secret from us today?
 * Rowan Atkinson, no doubt. Just look at him!
 * Johnny Knoxville. Like Roger, he takes way too much physical abuse and doesn't die.
 * President George W. Bush. The funny face, the speech impediment, the predilection toward violence... come on!
 * His environmental record reminds one of Judge Doom.
 * Jim Carrey. He did his own stunts in The Mask, they just want you to think it was computer animation.
 * Jack Black. There's a reason he's popular with kids.
 * Mick Foley, of WWE fame. Only a Toon could take hits like that man.
 * That Guy With the Glasses. There is no way Doug is a human.
 * Carol Channing. Clearly nothing like that could evolve in nature as we know it.
 * Pretty much every actor who played in Kung Fu Hustle.
 * Amy Adams. Enchanted was far more autobiographical than people think.
 * Chuck Norris The only toon in existence dip CAN'T kill.
 * Michael J. Nelson. His middle initial should be a clue.
 * Weird Al Yankovic. He may actually be Roger Rabbit.
 * Nicki Minaj does have toony qualities.

Toontown still exists today but by now it's pretty much its own parallel universe.
Only back in 1947 were there few enough Toons to fit in one town. Now Toontown is so spread out it's practically it's own universe, and each group of toons basically stays in their own little microcosm in the vast Toon multiverse. And now pretty much only the classic toons, and perhaps most of the Disney Toons since they've all met during things like the House of Mouse, are even aware that they are cartoons. The tunnel to Toontown was more like a portal to another dimension, and the Toons themselves are being created by the energy of the thoughts put into them by their creators and by their audience. Essentially Toontown is an astral realm.
 * So, like... a True Neutral version of The Warp?
 * Possibly closer to Chaotic Neutral, but yeah.
 * Wait...The Warp? Chaotic N-- OH MY GOD MAN! GET TO FANFICTION.COM! WE HAVE A FANFIC IDEA!
 * The tunnel to Toontown still exists. It's at a little theme park in Anaheim.

Judge Doom arranged the death of Bambi's mom.
After he  he decided to take a minor role as a minor villain while assisting Gaston in order to test out a new chemical in order to see if it had the capability of killing a Toon so he could use it later, this chemical he found out about from the animators   and infused it into the bullets to kill the animals as the actor he was assisting in order to get a accurate analysis on how it work. This could've gone in two ways, either he pulled the trigger himself when Gaston becomes guilt-ridden after seeing the extremely horrifying death of Bambi's mother by that we meaning melting, and decided to do the rest of the killing himself or letting the actor who played Man do it for him by playing on his ego as a hunter. This means Gaston was killing the animals including Bambi's mom and the pheasant that was flying away on Doom's orders. Doom delighted in the success of the work, had the chemical manufactured as "DIP" while Gaston lived on the luxury of the movie's success until 1991 when he met the end of his career as a small time hunter bad-guy, and the Weasels come back from heaven due to the fact that Toons never truly die, even after laughing themselves to death kill him off with Smart-Ass who was redrawn by the weasels who use DIP on him in order to keep the part their deceased master Doom played in Bambi a secret for all time.
 * It really makes sense to why we never see Bambi's mother's corpse; because the filmmakers found the death scene horrifying.
 * Also the pheasant was very scared of MAN, he's far, far from intimidating it had to be something so horrendous that it went against rational thought and decided to flee out of fear only to be shot down.   After that, the staff seeing how sick he is, decide to burn down the studio {the forest fire scene in the movie), but only manages to get themselves killed in the aftermath, while Judge Doom walks away and Gaston spends the rest of his career pretending to be a dumb Jerkass in order to repress the sight of that scene.
 * Word of God says that "actor" was Gaston. Perhaps after killing Bambi's mom due to Doom's setup, Gaston decided to become his braggart self to forget about the trauma [[spoiler: of having been involved in genocide and seeing Doom's real Toon face.

Judge Doom is Master Xehanort.

 * Don't dismiss it right away. First of all: I have scanned all of fiction for people with red eyes, and I keep coming right back to Xehanort and his incarnations. VERY red. Now consider that Xehanort lives in a universe populated by toons, and he interacts with many of them. Even though he is game-original, he may still be of the toon SPECIES, and this may only be apparent if he is drawn in 2D (which hasn't yet happened). He is also indestructible by weaponry, having survived an ultimate beat-down in Birth By Sleep, being crushed in both Kingdom Hearts I and II, and Word of God saying he's STILL going to come back!!! Therefore, he, like Goofy, cannot be killed by mere injury. He will have to be destroyed by Dip. This is further supported by the fact that in WFRR and KH respectively, he is the worst possible entity in the Disney-verse.
 * This of course implies that WFRR either takes place after KH, causing his ultimate death, or after his first death-by-Dip, he was resurrected by Hades. Because Hades is a Toon too, and he can do that, you know.

Judge Doom is Drew Blanc.
He was redrawn and un-tooned as punishment for his crimes. (OK, OK, this is only because they're both Christopher Lloyd with toons.)

Judge Doom is Oswald the Lucky Rabbit.

 * Cartoons used to be black and white, so his red eyes wouldn't have shown up. He was washed up when Universal got its hands on him, and when Mickey came around it was all over for him. He killed Teddy Valiant in a fit of rage, but then started thinking more strategically and created the Judge Doom persona. The Oswald in Epic Mickey is a cover-up story.

Picture of Toons are the result of photo-shoots.

 * Maybe toon-Cinderella for example goes into the Disney studios, puts on some dresses, is photographed then paid. These photos henceforth appear on Cinderella merchandise.

Some toons are physically unable to change what they're wearing.

 * Not most of them, just a select few. It would explain a lot.
 * And I can explain that: A lot of toons' heads are too big to fit through the hole in a shirt, so they have to have their clothes sewn on.
 * I reckon all Toons can change what they're wearing, but it's like extreme special effects makeup - it has to be painted on and it's a lot of effort, so most of them don't bother unless they need to do it for the animation. When just wandering around, they stick with a standardized outfit.

How Toons are born

 * It starts with a toon couple playing patty-cake, or doing whatever their sex equivalent is. As the toons play, a sliver of sound makes its way into the sky, onto some sort of floating cloud like feature, where some baby delivering storks live (like in the Dumbo movie). While humans and most creatures are incapable of hearing the sounds, the storks can, and occasionally, one of them will be inspired by the sound, and start to draw a new cartoon. The qualities of the sound floating up depend on the toon couple in question, and also influence how the stork draws. Once the drawing is complete, with a fully formed body and partially formed personality, the stork delivers the new toon baby to the "mother" toon in the original couple. And thus, a new toon enters the world.
 * Theoretically, a gay toon couple could have a baby this way!
 * Toons are born in any way that's funny.

Memes are mutations void of pain or pity.
They're basically living viruses of toon town, eating away at everything until there is nothing but paint. And unless one is ignored they grow until all is destroyed and they are the only ones left.

Roger Rabbit died when the refrigerator landed on him...
... and went to film noir heaven for the rest of the movie.

If there was prejudice and discrimination among the Toons. Then Fantastic Slurs go along with it.
A real life human calling a Toon an "Ink Stain" is equivalent to calling a Black person a N-word.

Roger stood under the bricks on purpose.
He lived according to the Rule of Funny, no matter what. He saw the bricks on his way in, and arranged the timing of his speech to give the weasel a chance for a visual punch-line. No wonder Jessica said he was "better than Goofy" -- comedic timing mattered more to her than a rescue.

Lola Bunny is the daughter of Roger and Jessica.
Just look at her! It would explain why she was nowhere to be seen in the movie... other than her not having been created yet in 1988...

Dip doesn't work on most modern Toons
Now that most 2D toons are created using Flash, or are completely CGI, Dip wouldn't have an effect on them because they aren't made of paint. These days maybe the only way to kill a Toon would be a computer virus or something.
 * Or a really big magnet or EMP.

Toons are completely bound by the Rule of Funny.
Roger claims that he couldn't have gotten out of Eddie's cuffs at any time, "only when it was funny." He literally couldn't have just removed his hand until a funny moment presented itself, even to save himself from half-drowning when Eddie had him in the sink. Laughter is a Toon's purpose in life and when they are offered a funny opportunity they absolutely have to take it, even if it involves humiliation (Leena Hyena watched Eddie change the street line but followed it into the wall anyway), self-injury (until someone turned off the skipping record or the joke got old, Roger wouldn't have been able to stop hitting himself with the plates in the bar), or their own death (Judge Doom couldn't have dodged that Dip to the face if he'd wanted to because the comedic timing was perfect). This explains Roger's seizure-like reaction while trying to hide from Doom's "shave and a haircut" routine: no matter how hard they try, Toons can't suppress the need to take advantage of a funny situation.

Also might explain why Toon Town is as crazy as it is - everybody and everything is playing along with every humorous scenario they encounter, dropping pianos and warping reality accordingly.

The sequel will be loosely based on Gary Wolf's second Roger Rabbit book, Who P-P-P-Plugged Roger Rabbit?
Since the first attempt was originally going to be a prequel chronicling Roger's start at stardom and takes places during World War II, chances are this newly announced sequel will follow another story, and it would only be natural that it would be inspired by Gary Wolf's second Roger Rabbit novel.

Toons can change their art style

 * This would explain the logistics problems of toon casting directors somehow finding several main characters and numerous extras in exactly the same (and required) art style.
 * They can change to CGI or claymation, or even a Muppet as well.

The animation quality depends on camerawork.

 * In our world the animation quality depends on the human animators and the time they have. In Toontown, the quality of the animation is based on how good(and thus, expensive) the camera they're using is.

Eddie Valiant is part Toon.
Think about it--he's rather weirder than he gives himself credit for. Either he doesn't know this, or he has a further Freudian Excuse for hating Toons because a Toon was, say, his deadbeat dad and he refuses to acknowledge his Toon half.

Judge Doom will be in Kingdom Hearts

 * He could be a perfect boss, or even a Heartless.

Judge Doom is Discord.
After The Return Of Harmony aired, Discord began to act like himself in the show, torturing other toons and causing chaos. He's nowhere near as powerful as he is in the show, but he can still shapeshift. He found a time machine that some toon invented, and used it to escape to The Golden Age of Animation. He put on a rubber mask and stuff to pose as a human, (because he was too lazy to shapeshift into a human) and pretended to be a judge. He hired the weasels and invented Dip, so he could torture toons For the Evulz. Later, he decided to take over Toontown, using this Dip. That certainly explains his shapeshifting abilities during the final battle.

Dip does not cause Cessation of Existence.

 * The only reason the weasels who laughed themselves to death became angels was because of the Rule of Funny.