What Measure Is a Non-Human?/Anime and Manga


 * Discussed in Bleach. One of the first story arcs deals with the idea that the generic, kill-on-sight enemy Hollows retain parts of their former souls and can even be redeemed.
 * And in the Hueco Mundo arc, multiple Espada explain that they see the Shinigami as the cruel ones because they slaughter Hollows mindlessly. Before Zommari dies, he rants to Byakuya about how Hollows are seen as evil and slaughtered simply because they need to eat humans to survive, saying that Shinigami are evil, biased murderers.
 * Also on the note of what measure a hollow is, during the Turn Back the Pendulum arc, 4 of the Gotei 13's captains, 3 of its lieutenants, and the Kido Corps' lieutenant were immediately ordered to be exterminated due to being guinea pigs in hollowification experiments.
 * A decision that may or may not have been influenced by Aizen.
 * Of course the whole debate falls flat considering that Hollows are, or were, normal human souls driven insane and twisted into monsters bent of devouring all around them. Not to mention that their dimension is a boring void full of similar psychopaths who would destroy them in a nanosecond if given half a chance. Soul Society kinda sucks, but it's better than that.
 * Not to mention that when defeated, the hollow becomes a plus and actually regains said sanity.
 * It's a Buddhist-influenced universe. Soul Society is a rest stop, and having too many souls leave circulation (unless Nirvana is an option) would cause The End of the World as We Know It.
 * Unrelated to hollows, but the anime's censorship seems to has something to do with this. Sajin Komamura (who had a caved in chest and severed arm), doesn't get his wounds censored in the anime like everyone else does (he even gets several more cuts across his body as Padding), when Hiyori was supposed to be cut in half, but is still whole in the anime. Reason? Apparently it's because he isn't human (remember he's an anthro wolf). Either the writers only do this to those who don't look human, or just flat out hates Komamura.
 * Averted in Monster Rancher where Genki is equally compassionate to the less human looking monsters, even the ones who are trying to kill him.
 * Mazinger Z: Discussed. In the original manga, three Iron Masks broke in the house of The Hero Kouji Kabuto. During the scuffle, he learns they are and they are just Empty Shells programmed to obey. when one of them tries to convince him to die and become like them, Kouji angrily yells such a thing not even would be human. Still, Kouji doubts about killing them, even if it is in self-defense, and when finally he gets forced to, he gets shell-shocked and later he wonders if he is not a murderer now.
 * Although never discussed in the actual webcomic/manga/anime, Axis Powers Hetalia has personified countries as characters, and fans tend to argue whether they are actually human or not.
 * Well, there's one Lost Strip where a Frenchman notices something odd about France, namely that he hasn't aged since the Crimean War. The 2011 version of the same strip tackles the issue more head-on, though France's answer is rather...cryptic.
 * More than a few fics explore the possibilities of this trope, though it usually doesn't go well for the Nations themselves. These themselves tend to result in them becoming either media freak shows or guinea pigs for testing.
 * Played with in the Hetalia Bloodbath 2010 event, where a newsreporter mentions the disappearance of 'those people.' This could possibly hint of their existence as fairly common knowledge (at least to certain segments of society), though probably not their true identities. Or alternately, they do know the truth but prefer not to talk about it.
 * And in the earlier 2007 April Fools event, Hungary suggests "exposing" France to the public as his punishment.
 * Actively explored in the Anime Ghost in the Shell, which was inspired by the book and movie Blade Runner. The Tachikoma spend long periods of dialogue pondering and debating this subject. They are, in fact, the subject of the subject, and the main characters join in to varying degrees from time to time. Ultimately, the other members of the force start to treat them more like people than machines and value their lives more.
 * How many mechanical parts does it take before a human is no longer human? The Major acknowledges that except for the few brain cells she's left with, she no longer has any human components, but based on the idea that she has a "ghost", whether or not that can be confirmed in a laboratory, she's treated as a human.
 * In the manga version, this trope is heavily subverted with the Tachikoma. During routine maintenance, one of them resolves to convince his fellow machines that they should have the same rights as humans, and in fact they are probably superior, and tries to start a revolt. The rest of the Tachikoma decide that humans aren't so bad and anyway if they overthrew them, there would be nobody to fetch them oil and give them maintenance so they treat the rebel as a lunatic. It's later shown that The anime also has the Major worrying about the same sort of rebellion. (Her concern about the Tachikoma is painted as a bit hypocritical, since she herself is rapidly approaching the human/not-human line from the other side.)
 * Uncomfortably done in Dragon Half, depending on how far past the slapstick you're willing to look; various non-human creatures with speaking parts (as opposed to "intelligent"; they're usually really stupid) have been indiscriminately killed and sometimes eaten, but when an apparently human girl gets stabbed, everyone gasps in shock. It turns out she's actually a half-slime, so (a) that's all right, and (hopefully) more importantly (b) she isn't hurt anyway.
 * Lampshaded in Hellsing when during their first encounter Seras ascertains that Alucard is not a human before shooting him. Alucard derisively comments on that: "Why? Would you have shot me if I was?"
 * The usual life value of the Monster of the Week in a Magical Girl show is subverted in Magical Project S, when it's revealed that Sammy doesn't vaporize monsters with her Stock Footage magic, but instead teleports them to an island in the middle of nowhere, where they form a peaceful, if somewhat eccentric, society. "Well, they're people too."
 * The rule of thumb in Sailor Moon seems to be that if you're a Monster of the Week, you're dead meat. Even you do display some level of sentience. Since the monsters of the week are always artificial life forms and in many cases actually transformed humans or created from the souls of the humans the Senshi are trying to save, there's some justification for this. But it is amusing that the value of their lives is never discussed. Of course in the manga, most of the villains of all walks of life get killed by the Senshi because they're pure evil and remorseless, so this discussion becomes moot.
 * This is also explored in Magical Girl Lyrical Nanoha in the second season. Mission Control has revealed that the enemy are in fact sentient programs, so "shouldn't be considered as people." Artificial Human comments that "they're just like me, then." Which results in a hasty response that really, she's just like other humans in that regard. Later as Nanoha confronts one of the programs who denies sentience, she retorts that if someone can talk to her and clearly have emotions, then it's obvious that they are people; just like humans.
 * It's suggested that the Wolkenritter were initially emotionless, but may have developed feelings as a result of Hayate's influence.
 * In the manga Samurai Deeper Kyo, countless humans are killed in several fights. In a possible example of executive meddling, the anime adaptation had all the evil characters turn into monsters at some point before they were dealt the fatal blow, possibly for the sake of preserving the good guys' "goodness".
 * In Trigun, the main character, Vash, refuses to kill any form of sentient life, including giant flesh-eating sand worms. Mindless sentry robots are, of course, another matter. The fact that he  may help. However, sentience doesn't seem to be the issue here so much as respecting all lifeforms (which the robots ...aren't?).
 * Vash placates the master computer and the robots stop, well, trying to kill things as a result. Considering the familiar, understanding tone he takes with the control room, he probably knew precisely what was going on.
 * In any case, the sentry bots were simply remote controlled extensions of the AI, which was unharmed (though annoyed) by their destruction, rather than independent intelligences.
 * In Robotech (and possibly the original Super Dimension Fortress Macross), it is only after the Zentraedi are discovered to be genetically compatible with Earth humans that the possibility of peaceful relations is even proposed.
 * In Macross Frontier, however, humanity eventually accept
 * The vagrant AIs in the .hack// series are treated as worthless and troublemaking pieces of data by the administrators, as is any human that sides with them. The main characters, naturally, see it differently. Nevertheless, they still left the game for good as a type of "growing up" metaphor, leaving the AIs to fend for themselves.
 * Kite returns in a manga set after the .hack//GU games, along with several fan favorites.
 * They mostly all die in .hack//GU, with the writers going after a different Aesop than the one in the first half of the franchise. The AIDA, unlike the aforementioned vagrant A Is, were attacking people and putting them into comas; including the protagonist's former love interest and the antagonist's little sister. That doesn't mean that their behavior's justified, but it makes it understandable. Also, the final attempt to kill the AIDA fails, deleting only their aggression, and there are no further attempts to destroy them after that. Also, there's a 'good' AIDA in the OVA, and Atoli offers the notion that Player and Aida can coexist peacefully.
 * The reason Ralph leaves the Union in Soukou no Strain is because.
 * A major theme in Bubblegum Crisis in all its incarnations (although the original OVA series is lighter on this content than you might expect, all told). The sexaroids Sylvie and Anri are more three dimensional and human than some human characters, and play a considerable role in Priss's acceptance of Boomers as being more than soulless machines (to the point that Sylvie and Priss's relationship, and its sexual/nonsexual nature, is a great source of online debate). That being said, the aforementioned boomers only appear in two episodes; the rest of the time, our ladies have no qualms about killing even seemingly sentient boomers.
 * In the remake, Bubblegum Crisis: Tokyo 2040, this was tied into the Myth Arc, when The Reveal showed that.
 * It should also be noted that the Boomers of 2040 only go insane because they've been created as intelligent beings and then had their intelligence altered, basically enslaved and lobotomised by humans. (How true this is for the original OVA is unclear, though.)
 * Boomers in Bubblegum Crisis are partially biological, which might make you support them further. However, Adama from Bubblegum Crash! was a fully sentient fully non-biological android (which was significant for one reason or another), and once again, Priss was the one who got the Aesop.
 * In the manga Gunnm, this is explored from pretty much every possible angle: human brains in robot bodies, human bodies with the brain replaced with a computer chip, even split personalities given bodies of their own.
 * This is a prevalent theme in Digimon. In the first, fourth and fifth seasons it was handwaved by the heroes since the digimon killed would return as digi-eggs. The human villains usually see only the Digimon as enemy's, while one glaring human exception and all the other vilains avert this.
 * The third season brutally averts the trope by demonstrating that there is no difference between digital and organic life, since both Digimon and Humans (military, innocent bystanders, car drivers) die permanently (no Disney Death) in this series. This is especially interesting because the most mourned death was Leomon's and not one of the humans . Early on, there is a debate/fight over whether or not to feed on wild Digimon's Data, strenghtning the partner Digimon, which is solved very subtely
 * The Big Bad (initially) in the second season of Digimon Adventure 02 turned out to be a troubled kid who thought that the setting of the series was just a computer game, and acted like many gamers are wont to in God Games. Upon discovering that it was real, he immediately changed his ways.
 * Strangely applied in the second season in regards to the good guys delivering killing blows to enemy Digimon. In the first season, the good guys were willing to kill enemy Digimon, as long as they weren't good Digimon infected with Black Gears. Yet in Season 2, the new generation of heroes is shocked and appalled by Ken and Stingmon's nonchalant killing of Thundermon during a fight, until it's discovered that it, along with other Digimon they encounter, are artificially made by control spires by a villain and are simply mindless drones (save for Blackwargreymon, who was made from 100 and developed free will as a result). When the Daemon Corps attack the real world, the new kids are uncomfortable about killing them, while the kids from season 1 are ok with it. Largely because these Digimon were basically terrorists, whose acts of ruthlessness included threatening a bus full of children.
 * The sixth season plays it straight completely, since the human characters have zero compulsion to spare enemy Digimon, without knowing if they'll ever be reborn, despite calling digimon friendly companions in the opening.
 * Justified that they are in a war, and that they only defeat enemy Digimon. They generally do not attack friendly or neutral foes.
 * Kurau, Christmas and other "Rynasapiens" in Kurau Phantom Memory get chased, abducted and generally regarded with great disrespect for the fact that they are half-alien hybrids with special powers. The matter gets confused since some Rynasapiens indeed have ulterior motives.
 * This is Sensui's dilemma as a teenager in Yu Yu Hakusho. Meeting  was one of the catalysts   for his fall from grace.
 * Also inverted later in the series when.
 * Melfina's primary conflict in Outlaw Star is the question of whether or not, as a biological android, she could count herself as alive.
 * Fullmetal Alchemist loves navel contemplation about this.
 * If your show includes a good guy who happens to be a suit of armor, homunculi, and human transmutation, you automatically invoke this trope.
 * The titular girls in Gunslinger Girl become less and less human in behavior as time progresses, which forms a jarring contrast with their appearance and is a source of confusion throughout the series. The loss of humanity is especially evident in the case of, who noticeably changes from a bubbly, sparkly child into a robot-like killing machine with sadistic tendencies.
 * She's never sadistic, just coldly efficient. She's never shown hurting people for the fun of it, only when her orders demand it. Also, before she became a cyborg, she was paralyzed and borderline suicidal, hardly bubbly or sparkly.
 * Early on in Angel Sanctuary, Setsuna was urged to kill his best friend, Kira, on the basis that as the spirit of a bloodthirsty, evil sword, there was no point in allowing someone with just the facade of humanity to live. Of course, Setsuna refuses . Kira himself struggles with his humanity or lack thereof throughout the series, generally insisting he never wanted to become human.
 * Astro Boy dabbles in this. Atom/Astro, after all, was abandoned by his Mad Scientist father, Dr. Tenma, when he failed to serve as a complete replacement for his dead son.
 * Human and robot relations in Astro Boy are driven up to eleven in Urasawa's retelling, Pluto. How human do humans see robots as? How human do robots consider robots to be? How do people feel about it getting harder and harder to tell man from machine? What do older robot models think about newer androids that outclass them both in body and in sentience? At what point do machines count as people? What about robot rights? How many more philosophical questions on artificial intelligence can we cram into the next chapter?
 * Some of Kyon's biggest Pet the Dog moments in the Suzumiya Haruhi novels come from his treatment of . He treats her the same as he treats everyone else and refuses to use her abilities and obliging nature any more than is absolutely necessary, to the vocal surprise of the pragmatic Itsuki. His treatment of someone who is actually omnipotent as neither an object of worship nor something to be controlled is also an example.
 * The alien Arume in Blue Drop create synthetic children to function as bombs or as devices to clean up the remnants of their own biological weapons. All of them are female with bright blue eyes and white blood, just like the Arume themselves, and they grow up just like normal children. Quite a few earthlings definitely regard them as human and try to protect them from their fate and the prosecution of other earthlings. The synthetic Arume also share their creators' tendency to fall in love with earth girls, which makes things even more complicated and leads to a lot of drama in the manga.
 * Bounen no Xamdou features people turning into "humanforms", huge monsters that generally spew destruction. When the hero kills one in order to save another human, he gets called out on how he's being a bigot.
 * In Basilisk, the ninja are all technically human, but many of them are extremely freakish-looking humans. And there is a clear tendency for the more grotesque ninja to die first.
 * In the adorably squicky Alien Nine series, elementary school girls bond with deadly alien symbiotes that look like winged fish helmets to combat alien invasions, or alternatively extinguish spy rings preceding invasions. The symbiotes are experienced at this sort of thing...The girls...Less so.
 * Averted most significantly by Keiichi in Ah! My Goddess. He's willing to reason with others, regardless of what they are. He even aided the demon angel, Blue Lance.
 * Done somewhat disturbingly in Inuyasha. The titular character's "good" qualities, are measured by his unwillingness to kill humans, even horrifyingly evil ones. However, he kills demons without a second thought. This is true of all the characters, but it's a little disturbing with the demons and half-demons: the "good ones" are the ones who value human life, but seem to place no value on the lives of their own kind. It seems like even humans who are murderers and rapists are worth more than demons who are little more than irritating pests.
 * Kagome's bizarre insistence that Inu-Yasha is "may be half-demon, but is half-human too" so can be a good guy is strange given that she's traveling with full-demon demon; Shippo; who is the most innocent member of the cast.
 * This is most evident in an early episode when the title character, in a berserk rage, nearly killing some human bandits who had killed half of a village and enslaved the survivors was treated as approaching a Moral Event Horizon.
 * Might as well point at Inuyasha himself. You know if it weren't for that half HUMAN in him, he'd be a complete and utter monster not worth the viewers/readers pity? Just watch when he goes into beserker full youkai mode. No compassion, no heart, no guilt, no redeeming qualities. Then he reverts back to being the hanyou, and that's when the regret kicks in, just to emphasize it's only as good as his human side. Not to mention he just continually becomes nicer towards humans only the more the series went on - this coming from a guy who suffered obvious discrimination from these humans just as much as from the youkai. Of course unlike humans, who just keep rubbing it in of what his heritage is, he's expected to just put up with the humans' taunting and ignore it, just to prove that he's the "better man" in a sense. But woe be it if a youkai were just to only call him a hanyou! Ensue spamming of the Kaze no Kizu/Wind Scar until that youkai was hacked away that their body won't even repair in hell.
 * In Inu Yasha's case, its the fact that he's half human that keeps him from being able to control the daiyoukai level youki he inherited from his father. As a full youkai of the same lineage, Sesshoumaru doesn't have any trouble keeping his cool (even if his moral compass was a lot closer to Complete Monster than most people, until he met Rin) and started to listen to Tenseiga), and even he felt fear at the sheer strength of Inu Yasha's full youki the first time he faced it.
 * It doesn't help that the series goes on and off about whether or not youkai are inherently evil.
 * It should be noted that "youkai" isn't a species as much as a classification, which seems to be "beings who naturally produce and utilize youki, which is extremely corrosive, both physically and emotionally, to human beings." There are youkai races like the Dog/Wolf/Bat/Snake/etc... tribes, but there's also youkai (unique and types) that are formed from an aggregation of negative emotions (Yin Energy) or special situations like the Muonna or the Flesh-Eating Mask, which are usually a lot closer to Always Chaotic Evil (though the former was sympathetic, what with her extreme mother complex). Since Youki is basically the spiritual equivalent of poison to humans and naturally causes extreme bloodlust in beings that aren't powerful enough to resist it (Inu Yasha's actually incredibly resistant compared to most high level humans and youkai, which is another indicator of how strong his full youkai side's power is), so a case could be made that the bandits would be a lot easier to redeem, or some such. Still, a lot of youkai that they slaughter don't seem any worse than those bandits, and in any case, Inu Yasha has killed humans that have become youkai -- or something like it -- several times without any qualms, so its possible that his distaste for killing humans is more because they're basically made of paper to everyone on his side. The bandits in particular had been fleeing or begging for mercy at the time he slaughtered them. Also, only Inu Yasha and his friends found his killing of the bandits to be a Moral Event Horizon, and that's probably at least partially because they knew how out of character it was for him to enjoy slaughter that much.
 * There was one demon who was ordered to steal tetseiga from Inuyasha. After he was caught Kagome says, "If you do it again we'll slay you."
 * of Higurashi no Naku Koro ni
 * In Video Girl Ai, the Video Girls are Robot Girls specifically created to help humans who are good-hearted and need emotional/moral support. However, they're supposed to follow only the orders of their creator and/or the needs of the client. Then, one of the Video Girls has her tape played in a broken VCR... and she starts to develop human-like feelings, like falling in love with the Unlucky Everydude she's supposed to aid. As punishment and/or preventive measure, she should have her tape returned and then be "rebooted", but is this the right option? Or should said Video Girl be released and allowed to pursue her own goals? And let's not even think of what would happen when a Video Girl is assigned to an actual pervert...
 * Elfen Lied seems to decide that yes, Diclonii are people too.
 * In both Appleseed movies all cyborgs besides protagonist Briareos are expendable, and mostly evil. The Final Boss at the end of Ex Machina is even more blatant version of the trope - she's been resurrected from the dead with cybertechnoloy, and as result has become something of a Borg Queen. However, the protagonists manage to briefly medicate her with micromachines and bring her back to her senses, at which point she begs to be allowed to die as a human. When two of the three protagonists present are a cyborg and a Bioroid, both very clearly fully functional people.
 * The Witchblade anime played a with this, in different forms. That is, would it be okay to use dead bodies as reanimated soldiers with electronic 'brains?' And if that soldier's conversion is a successful model, what about cloning him, but as the state he is now? Masane is at first horrified when she discovers . Takayama just considers this to be more expendable than living human soldiers. And NSWF producing the cloneblades are more squicky. Then there's one Tyke Bomb obsessed with attempts to understand who and what she is. And several quite "real", but batshit insane humans.
 * In Darker Than Black many people aware of them think Contractors and Dolls are "no longer human". Dolls may be sold and treated like furniture or devices, Contractors are perceived as a sort of killer robots. Not that there weren't any reasons at all for such an attitude, but...
 * In Pretty Cure the girls complain about having to kill the first villain and are told by their Non Human Sidekicks that they're just making him "return to the darkness". Later they find that does a Heel Face Turn... incidentally proving that the enemies aren't Always Chaotic Evil after all and killing them should count as killing people, which is never even mentioned.
 * In Waq Waq, Shio, the son of a "Guardian" tasked with defending villages from machines, initially struggles with this after meeting the friendly Pura, but comes to the conclusion that humans and machines can be friends.
 * While the Bugrom were in the process of conquering the humans in El Hazard, you'll notice that no one seems to care the OVA ends with nearly their entire race being killed because they're 'icky bugs'. The fact they display signs of intelligence and personality around the one human to speak their language is ignored.
 * Actually, the Bugrom weren't really killed. They were simply sent to another world/universe. Point taken, though.
 * Chachamaru has been having an inner debate on this one lately. She wonders if she has a soul and can therefore make a pactio with Negi. But as far as the story goes, she definitely qualifies as 'human' as do they local vampire, the half demons etc. But the other robots like Tanaka are definitely just machines, despite speaking on his first appearance. Presumably because they all have the same form, and it's not a cute one like Chachamaru's. And their not as much Magitek as she is.
 * The official position on the souls of artificial beings is
 * Magic is just racist. Or Model Number-ist. Or Type-ist. Or whatever it would be that applies to robots.
 * Also referenced with regards to  once his Dangerous Forbidden Technique starts turning him into a demon. Its explicitly stated that he'll be a higher level of being, but he'll also become "a beast", no longer human.
 * However, this doesn't quite count in reference to this trope. Even though  would be no longer considered 'human'   would still probably be considered a person, as Negi definitely considers Evangeline, a vampire, to be a person, and the end result of turning into a beast was commented to be similar. The better example would be
 * Subverted in To Aru Majutsu no Index for clones. About ten thousand MISAKA clones have died already, one dies at the start of episode ten and another at the end.
 * Kazakiri Hyouka is an interesting example of this as she is an individual consciousness and yet is also a sentience of the AIM field created from all the Epsers of Academy City. In particular, she decries herself as a monster (twice in the anime, at least) and it's Touma and Index who say otherwise. That doesn't stop Aleister from treating her like a tool as suits his needs.
 * Tree Diagram is considered the pinnacle of Science-side artificial intelligence. It is destroyed at the start of the main series and, despite a crushed attempt to rebuild it for the purposes of continuing a cruel experiment, largely goes unmourned.
 * If you can look past the rampant Fan Service, Fetish Fuel, cuteness and comedic moments, this is a major element explored in Chobits.
 * Vampire Princess Miyu. OH SO MUCH. The Shinma, especially humans made into ones, can be endearing, if villainous. If anything, poor little Hiyoku...goes through hell, turns into a Shinma and expects life to be better, only to get fried. Also related to this is the pair of good rogue Shinma who end up frozen by the Queen Bitch Reiha in the Light of the Sea arc, and some others.
 * In the Yu-Gi-Oh!! English anime, the deaths of human characters (as well as many threats of death of human characters, like Marik's Rare Hunter duels) are censored with banishment to the Shadow Realm (for instance, instead of Marik stabbing his father as he did in the Japanese version, he banishes him to the Shadow Realm). They do not seem to have a problem killing off monster characters, like the Great Leviathan and Zorc, or evil spirits like Yami Marik (though Yami does say he will "vanish into the Shadow Realm", but he seems to explode nonetheless) and Yami Bakura. A few exceptions to this have been made; Mahad is destroyed, though he becomes the Dark Magician (a Duel Monster) first. Cecelia Pegasus is said to have been killed by an illness, and of the seven who perish in the virtual world when it is destroyed (Gozaburo, Noah, and the Big Five) only Noah's death is censored (because he is the one who turns good), by the characters speculating that he saved his mind on a backup drive. However, in this case the Big Five are all imprisoned in unseen corners of the virtual world as it is destroyed (and have barely been mentioned since their defeat), and therefore their deaths are offscreen, while Gozaburo transformed into a fire monster at the end and even survived for a few seconds, as a beast of fire in the real world, where he attempted to eat the blimp and everyone in it.
 * Mostly averted in Slayers. The protagonist humorously blow up non-human and human mooks with equal enthusiasm, although there are more non-human mooks that attack them. If any bloody slaughter is shown, it's pretty much always of non-human races, but the story and the protagonists don't treat it as if it isn't terrible. Perhaps the series uses this trope because dead humans will get them M-ratings, but they manage to avoid most of the Moral Dissonance.
 * This is pondered upon by Uragon from The Tower of Druaga, which surprises some viewers since he was The Neidermeyer up until that point. This came up after he saw that he was the only one who wasn't visited by anyone when the various groups ended up at the House of the Dead (no relation), and found one of Pazuz's magic knights when he sat down on a bench.
 * Contemplated in Rumiko Takahashi's Mermaid Saga. The monstrous, violent "Lost Souls" --humanoid, scaly beasts with frog-like appearances and enormous strength-- are the remains of an unlucky human who ate mermaid flesh and neither died instantly nor became immortal. For the most part, they're treated as Giant Mooks driven by instinct and prone to violence, so the protagonists destroy them in self-defense with nary a thought. But then Mana is saved by one who retains enough intelligence to dress in robes and hide his horrifying demeanor from others, even living as a hermit in the woods for his own safety as well as other people's (although he also has the strength to dig Mana out of a landslide or tear a deer's head off in order to feed.) Mana comes to understand him and realize that, even as a Lost Soul, he's kind and gentle and wants to keep her safe... but neither Yuuta nor the villagers know this, and the Lost Soul is killed as all the others.
 * One Piece plays with this trope several times.
 * It first occurs in inverted form; the Arlong Pirates believe fishmen are a superior race and humans exist to serve them.
 * It occurs again in Sabaody Archipelago. Humans view fishmen and merfolk as lesser beings and enslave them. In fact anyone that isn't a normal human is viewed as a lesser being, including giants and mermaids. Regular humans can also be enslaved and are then treated in a similar fashion.
 * The Celestial Dragons think that everyone is inferior. They are allowed to do anything they want to almost anyone. One Celestial Dragon rides on a human slave, kicks a dying man out of a stretcher, forces an engaged woman to marry him, and shoots her protesting fiancé. All of this is done within minutes of his first appearance.
 * Tony Tony Chopper plays with this trope on the boundaries of human and animal, being the only one of the crew who is not human and never was, but merely adapted his humanity from a devil fruit, though surprisingly the series rarely addresses it outside of his own back-story flashback.
 * Bartholomew Kuma lives with this trope in a manner similar to Major Kusanagi, where he gradually loses his humanity as more and more of him is changed to cyborg, though in Kuma's case there was a distinct line drawn by one last procedure to remove his independent humanity entirely.
 * The zombies of Thriller Bark were usually treated as Zombies according to the norms described in this trope, except for Cindry, who does somehow gain a bit of her old humanity back, before being killed.
 * Remember the Seakings, giant creatures living in the oceans and casually cut in half either for feeding the prisoners of Impel Down or because they simply were in the way of someone? How this will affect any of the characters and their dealings with them remains to be seen. However, their latest antics suggest that they continue to have no qualms whatsoever with using them as a source for food.
 * In Zettai Karen Children, the conflict between humans and espers generally falls under another trope, but in one episode this is tackled head on, when Minamoto argues for the destruction of Momotaro on the grounds that he's an animal, not a human, and a dangerous one. The Children veto this rather forcefully, and Sakaki notes that "they see him as one of them." Later, Kyosuke (an esper) challenges Minamoto to shoot him down in front of Kaoru and show her how humans treat "dangerous animals."
 * This is a major theme in Eve no Jikan. A particularly jarring example is when
 * This is kinda tricky in Berserk, as Guts, who was originally a mercenary, has killed scores and scores of scores of people with little  to no qualms (so long as they weren't people that he liked). But after some life-changing events and a sudden career change, Guts now kills scores and scores and scores of monsters - some of which who use to be human. This trope was best exemplified during the Lost Children Arc, where Guts fought with the apostle Rosine and her apostle spawn even after learning that they were still children. Now, Guts has become quite ruthless after the Eclipse - and with understandable reason - but he still tries to remain as human as possibly by not killing willy-nilly; rather, he'll merely threaten to kill you, mainly if you're either unarmed or a woman or a child. But if you make the choice to become an apostle - that's it. Guts doesn't have a lick sympathy for you anymore. Even if you have loved ones begging for mercy nearby, he'll shove them aside and won't just kill you: he's going to maim you and force them to watch.
 * In Naruto,