Shut UP, Hannibal/Video Games

Examples of a reaction in  include:

"Riku: Wrong. The truth is... you just really stink."
 * Mega Man Zero: Zero gave Dr. Weil one of these. Dr. Weil is boasting how a heroic reploid like Zero wouldn't be able to harm a human. Zero responds by telling him he's actually not quite that noble and he's always only fought for the people he believed in and not some nebulous "defender of humanity" title, and as far as Zero's concerned, Dr. Weil's just another maniac that needs to be put down. What's particularly delicious is that Zero is not a Reploid, and that he was not necessarily constructed with the Three Laws to begin with - what with being built by Doctor Wily and all.
 * There's also when Weil is gloating to Zero about how a reploid could never understand that joy he's experiencing of controlling all the Reploids in the world. Zero replies by saying that he doubts that most "sensible humans" could understand either.
 * Axl interrupts the final boss speech of Mega Man X 8 with a bullet to the chest. "Don't forget, he's the enemy!" Perhaps his sole redeeming moment in the series.
 * Devil May Cry 2 has one of the most epic Shut UP, Hannibal demonstrated here.
 * The usual response of Yuri Hyuga to a Break Them by Talking can be summed up as "Oh, don't give me that crap." Then he beats the hell out of today's unholy abomination.
 * In Covenant, Rasputin, facing down Yuri, simply calls him "Demon!", to which Yuri.
 * Even better was the scene just before the battle with . After rants about his intention to destroy the world, Yuri asks him for a favour. When  asks him what it is, Yuri says "I wish you'd shove it. You know where." The ensuing silence is incredibly satisfying.
 * In Star Wars: Knights of the Old Republic, an optional piece of dialogue between Republic soldier Carth Onasi and Mandalorian Canderous Ordo starts with Canderous asking Carth what battles he had fought in during the Mandalorian Wars. Carth replies that he prefers not to dwell upon the horrors of war. Incredulous, Canderous replies that he would have thought that a fellow warrior would have understood the glory found in battle. This is apparently one of Carth's BerserkButtons, as he angrily snaps back he isn't a warrior, he's a soldier, in an awesome Take That: "Warriors conquer and enslave, they prey upon the weak. Soldiers defend the innocent, mostly from warriors." Canderous snarks that Carth must tell himself that every night so he can sleep. Carth responds by asking Canderous what that Mandalorian code means when they lose, "y'know, like you did against us". Canderous fires back that the Republic had the advantages of more ships, more troops and the Jedi, and that the clans still nearly won. Carth asks him if he tells himself that every night so he can sleep. It's a SUH tennis match.
 * A rather amusing one in Knights of the Old Republic. Normally you cannot take Bastila with you on Korriban, however there are intact scenes and dialogues that can be activated with a mod. One of these has you learning of the Sith temples. Bastila begins to comment when she is sharply cut off.
 * Done in Kingdom Hearts II when Xemnas tries a Break Them by Talking on the heroes about how he had no other choice than to commit the actions that he did, only for Sora to say "Give it a rest! You're Nobodies. You don't even exist. You're not sad about anything!" Xemnas then laughs and confirms this.
 * delivers another Shut UP, Hannibal in that scene when Xemnas asks the heroes why they considered Organization XIII to be an enemy: "That's simple. It's because you mess up our worlds."
 * There's actually a better example with Riku in Chain of Memories, just before the final boss when Ansem tries to tell to him that he's irrational for accepting the Darkness in his heart but not Ansem... His response? (Foreshadowed by the fact that Riku has constantly shown an ability to actually smell people's auras).

"SHODAN: I don't understand... how could you have done this? You weren't meant to be so important... and now you think to destroy me? How dare you, insect? How dare you interrupt my ascendance? You are nothing. A wretched bag of flesh... what are you, compared to my magnificence? But it is not to late... can you not see the value in our friendship? Imagine the powers I can give you, human. The cybernetic implants I gave you, were simply toys. If I desired, I could improve you... transform you into something more efficient. Join me, human, and we can rule... together. Soldier: ... Nah. (shoots SHODAN)"
 * Done in Kingdom Hearts II twice, when Sephiroth tells Cloud to give in to the dark side and Cloud literally tells him "Shut up."
 * Don't forget the first game, there Sora for the first time fights Maleficent. Before the battle she begins to rant about how nothing can stop her now from conquering the universe. Sora responded by telling her "We'll stop it! After comming this far, there's no way we're gonna let that happen!". Maleficent didn't take the challenge well.
 * In Assassin's Creed, Majd Uddin attempts to give Altair a Not So Different speech about how it feels to hold the life or death of someone else in your hands. Altair's response is to say he's learned what happens to those who elevate themselves above others, and then stabs him in the neck.
 * However, it's horribly inverted in the game. You must listen to every target's speech in an Unskippable Cutscene - both before and after the assassination.
 * From System Shock 2, delivered by the Soldier, the main character, to SHODAN, the villainous computer system:

" It's because we couldn't do that! That I... we... wanted a place of our own! Zelos: Uh-uh. Sorry, but don't act like you're the only victim here. It doesn't even come close to justifying all the things that you've done."
 * It is worth noting that this is the only time the protagonist speaks in the entire game, to amplify the awesome.
 * In Fable II, in the final confrontation with Lucien,
 * In Oblivion, when the protagonist finally meets Big Bad Mankar Camoran, the villain launches into a gloating speech...which the protagonist can end at any time with an attack.
 * In Killer7, after the stylish duel between Dan Smith and Curtis Blackburn, the latter tries to justify saying things like "Everyone should have a hobby after retirement" and "All I ever wanted was to shed a light in my life". Dan, his old partner and the one with the least moral issues in the Killer7 syndicate, is visibly disgusted, and after saying "Trying to die in style? Gimme a break, you sick old man!" shoots a lever that gives Curtis the same treatment he gave to.
 * In the Game Boy Color version of Rainbow Six, after defends his plan to spread a virus across all of human civilization by introducing it at the Sydney Olympics by saying "At least my way, the animals would have survived," one of the members says "This way everyone survives," absent from the PC version.
 * Happens a couple times in Tales of Symphonia: though the best one is probably right before the final boss, where the Big Bad is trying to give a Freudian Excuse for his actions.

"Emil: I won't die. The you taught me spurred me on. We'll make sure that this world doesn't turn into a demonic realm!
 * In Tales of Symphonia: Dawn of the New World, the final boss does this to you while the heroes try to convert him if you let the battle conversations go on long enough. Though . He actually does it about 5 times in the conversation, each time telling the heroes that he doesn't want to hear what they're saying, that he just wants to kill them, but the end of it has the most "SHUT UP!" about it:
 * Silence! I won't be distracted by your appearance any longer!"

"Scirocco: By averting that Colony Drop, you wasted a good chance of getting rid of all those fools whose souls are bound by gravity. Kouji: Oh, don't give us that crap! We won't let you even touch the Earth we live in! Scirocco: The lives of those who cannot understand genius are of no importance to me, since genius surely is the driving power of the world. Daba: This Scirocco guy is just as bad as Posaydal... and I'm afraid the same mistakes will be committed in this universe as well. Kamille: Scirocco! We're not letting despicable people like you, who laugh at others from their comfy seats, get away scot-free! (the heroes proceed to pummel the living heck out of Scirocco and the Titans)"
 * In SD Snatcher, the master Snatcher is lecturing Gillian on how it's plan will succeed and snatchers will destroy the humans. Gillian's response? "No way, dickhead! Not when Gillian Seed is alive!!".
 * Happens quite often in Super Robot Wars:
 * In episodes which feature Zeta Gundam, this is the heroes' usual answer to Paptimus Scirocco and his Utopia Justifies the Means mentality. An example from Super Robot Wars Compact:

""Shut up! And listen! My name is Sanger, Sanger Zonvolt! The sword that cleaves evil!""
 * And in Alpha 3, during the re-enactment of Gundam Seed's last battle, Rau Le Crueset proceeds to give the Alpha Numbers the same "The Reason You Suck" Speech that destabilized Kira in the canon series, telling them that Humans Are the Real Monsters and that all their efforts are doomed to failure. In response, the heroes basically tell him that he's full of crap.
 * In Advance, a similar exchange occurs between the Londo Bell and Evil Chancellor Haman Kahn during her attempted Axis drop. At the heroes' protests, Haman says that she's only doing what is best for mankind's future. Banjou Haran, the protagonist of Daitarn 3, retorts that she, and only she, decided it, and that nothing gives her the right to commit genocide for her supposed higher ideals.
 * Alpha and OG timelines have probably the most memorable user of that trope:

": My sorrow at its ruin runs deeper than the deapths of the underworld... do you not understand? Sonic: No! And I don't want to!"
 * In Skies of Arcadia, spend a good few minutes explaining how horrible, greedy, miserable, etc humanity is and uses it to justify . Although you are given a choice in how to respond, the one that increases your Swashbuckler Rating and is in-character for Vyse is the one where he tells them to shut up and exclaim loudly that  just because the world doesn't live up to their standards, with double burn points for the fact that they've willingly isolated themselves from said world and could have chosen to do something more constructive about it all this time, but never did.
 * The best part about this is
 * There are several of these in Sonic and The Black Knight when Sonic confronts, who explains that the only way to save Camelot from its tragic fate is to use the power of Excalibur's Scabbard and the Underworld to make it eternal, only to have Sonic reply "What good is a world that goes on forever!?" The conversation even ends with this great exchange between the two characters:

"Shadow: You're boring me to death, Black Doom!"
 * From an earlier game, after Black Doom has given Shadow a Break Them by Talking about how it's In the Blood and that Shadow must join him:

"Yosuke: Favored by the world, my ass. I'm just gonna say it flat out. You're just a worthless criminal!"
 * In Resident Evil 4, resident dragon Ramon Salazar prepares to go into a speech about terrorism and how he has a "special" trap all set up for Leon... until Leon throws a knife across the room and sticks Salazar's hand to the wall.
 * Another top example is from the climax of Resident Evil 5, where Chris Redfield shuts up series Big Bad Albert Wesker's latest hammy declaration with "I've had enough of your BULLSHIT!".
 * Kingdom of Loathing, due to its parodic nature, does this repeatedly. From the fight with the hobo Mini Boss Oscus: "You figure the best way to stop this speech is to hit him."
 * Against the Naughty Sorceress's second form: "You found me beautiful, once..." she says. "Honey, you got real ugly. Yo, she-bitch! Let's go!"
 * Why does that sound familiar?
 * Persona 4 has this happen after the revelation of the killer. In a long-winded spiel, the killer explains that the TV world is the best thing to ever happen to anyone. The heroes' response?

"Balak: I gave you the chance to save them and you turned it down. Who's the real terrorist here? Shepard: You are. But you're dead. (shoots him)"
 * Also Deconstructed—when your inner Shadow Archetype begins revealing facts about your inner character you'd rather not hear, despite being utterly true, denying it and asking it to Shut UP, Hannibal is a very, very, very poor idea. The thing that eventually defeats the shadows (after the inevitable Boss Battle) is to do exactly the opposite and own up to their claims, using the knowledge that you have a problem as a foundation for improving yourself. It also gives you superpowers.
 * In the Mass Effect DLC mission "Bring Down The Sky" you're given the choice between saving the hostages and letting the terrorist escape or killing the terrorist and letting the hostages die. If you pick the latter, once you're done dispatching his mooks you come up to him. Picking the Renegade option leads to this exchange:

"Shepard: You talk too much. [BANG!] Krogan: See? The human cannot even hit a simple target! [BOOM]"
 * Mass Effect 2 contains many of these thanks to the interrupt mechanic. A particularly awesome one involves an arrogant krogan and a gas line.

"Grom: The blood haze has lifted... the demon's fire has burnt out in my veins... I have freed myself... Thrall: No, old friend. You freed us all. (roars in mourning of Grom)"
 * Another epic one occurs in the Kasumi DLC. You're in the villain's vault full of priceless artifacts to steal back something, and a giant hologram of his head appears to tell you that he knew you'd come and now he has everything he needs and blah blah blah. A Crowning Moment of Awesome invokes this trope when Shepard checks his pistol while Hock blathers on, levels it at a priceless vase and calmly blasts it to shards. "Do I have your attention now?"
 * At the end of the second game,
 * Speaking of Shadow Broker, Liara gets one later in the mission.
 * A truly epic one comes in Mass Effect 3 after you . It is giving the standard monologue about how organic civilization is totally outmatched, you will all die, their victory is inevitable, blah blah blah. Shepard retorts by directing an orbital strike from the Migrant Fleet directly into its face.
 * Equally awesome is the Paragon interrupt during said rant: Shepard
 * Grom Hellscream in Warcraft III gets quite possibly the most bad assed one ever. After the gigantic Pit Lord Mannoroth, who wields a double-ended pike that's as long as two men are tall, defeats Thrall effortlessly, he gives Grom a short version of a Not So Different speech. Grom responds by roaring, charging at Mannoroth, killing him in one hit, and then being mortally burnt in the ensuing firestorm. He goes with a smile on his face, pleased that he managed to free the Orcs from their corruption for good.

"Go to hell, you son of a bitch!"
 * Immediately after killing Aeris in Final Fantasy VII, Sephiroth starts to give his umpteenth villainous speech about how everyone will live again as part of him when he absorbs the lifestream and becomes a new god... and Cloud achieves a brief Crowning Moment of Awesome when his text box pops up and actually covers up most of Sephiroth's speech with the words "... Shut up."
 * Even the Turks get one of this in on Don Corneo in Wutai, after Cloud And Friends and the Turks team up to release Yuffie and Elena from Corneo's clutches. Mostly they turn his Reason You Suck Speech against him. And it is awesome.
 * A variant takes place in Wild ARMs 1, when Zeikfried ensnares Rudy's arm with a cord to try and drag him into a black hole, and goes on about how the two of them are Not So Different, even calling him "brother" and saying that if he goes down, he'll take Rudy with him. Rudy's a Heroic Mime, of course, so his action speaks a thousand words --
 * In Silent Hill 3, what is Heather's reply to Leonard after the zealot claimed that a heretic like her only deserves a gruesome death? "Is every person here a mental case? [...] Well, I suppose you're not a person anyway." and then she proceeds to shoot him in the face with a shotgun.
 * Heather has a talent for telling Hannibal to shut up. She repeatedly smacks down Claudia's elaborate speeches about how the world needs her rather twisted brand of salvation, with lines like "you self-righteous witch, nobody asked for your help!"
 * Heather nails it near the end of the game when Claudia becomes elated by : "Shut your STINKIN' mouth, bitch!"
 * In Baten Kaitos Origins, after the Duel Boss battle, Baelheit tries to justify his attempts to blow up floating islands by stating that people's reliance on their powers of hearts will cause them to repeat the War of the Gods, the massive calamity that destroyed most of the world and caused islands to float in order for people to survive. Sagi's response? He states that Baelheit's reasoning is all self-righteous crap and that Baelheit can keep all the excuses. And then Sagi proceeds to knock Baelheit to the ground.
 * Sagi gets several of these. To Shanath:

"Save your monologue for the next world. Sagi, let's finish him."
 * Guillo gets a good one when facing down :

""You don't believe in anything. You gave up on life before you were even born. Sat poisoning Cocoon from the inside, waiting for someone to come and destroy you. Sure, you think the end of the world is salvation. All you care about is death's release. So take it, and leave the rest of us alone! We don't think like that. When we think there's no hope left, we keep looking until we find some. Maybe Cocoon is past saving, but it's our home, and we'll protect it or die trying! We live to make the impossible possible... that is our Focus!""
 * The Legacy of Kain series uses and averts this - both Raziel and Kain have about a 50/50 tendency of either listening to the tirades of Moebius and the Elder God or telling them where to stick it. The chances of doing the latter increase as soon as they find out how to neutralize Moebius' paralyzing staff or escape from the Elder God's realm.
 * Len vs. White Len in Melty Blood gives us one of the very few times Len ever actually says anything. White Len is sneering about how she is the voice and mind of Len and how much Len sucks and should just go away and die or something. Len tells her to shut up, she has her own will. Since she's currently the PC, she obviously wins.
 * Colonel Hakha in Killzone delivers one to General Lente with a shotgun shell after the latter reveals that he had the former's brother killed. Delivered later to if you play Hakha in the final level, when the former delivers a line about how they're Not So Different.
 * In Tales of Vesperia, gives a speech saying how  is necessary for preserving the world, and how finding an alternative way is pointless. Yuri cuts him off and states the fallacies of  logic in a true Crowning Moment of Awesome.
 * While completely ignoring
 * A better example happens later, when . The entire party, including, take turns telling him to shut up.
 * After defeating Dracula in Castlevania Judgment, Maria will occasionally thank him for skipping the speech this time. Not everyone is fond of "What is a man?", it seems.
 * They're afraid of the wineglass.
 * In Neverwinter Nights 2, during the conversation after defeating, during her "The Reason You Suck" Speech (with a good helping of Nice Job Breaking It, Hero), one of the dialogue options is "Snap her neck." Doing so obviously cuts it short.
 * Most of the boss battles in Final Fantasy Tactics consist of you shutting up the enemy via superior firepower, as they will at various points through the battle taunt you about their supposed superiority until you defeat them. One of the most satisfying deliveries of such a Shut Up Battle is against Algus/Algrath.
 * Elmdor shuts up Barinten/Barringten by having his assassin toss him to his death when he confronts Rafa on the rooftops of Riovanes Castle.
 * Dissidia Final Fantasy has several examples. Ultimecia in particular not only gets a good snarky one from the Warrior of Light ("Are you finished talking?" ... "If you have no business with me, you should leave now. The world's time runs short. There is not a moment to waste with the likes of you.", she also gets an even more badass one from Squall after he defeats her in Shade Impulse: he responds to her preaching about time by finishing her off with his gunblade, before she'd finished talking.
 * Which of course is a reference to her original game where she gives a similar speech during the final battle and gets struck down mid-sentence.
 * Lightning in Final Fantasy XIII does this to . He only manages a creepy laugh and three words before she gives him a lecture that lasts about a minute. But it is an awesome minute.

"* Rants and raves on how she'll gut him and suck the marrow from his bones* Patrick: * Lights her severed head on fire and tosses it off a cliff* The family will be reuniteeeeeeedddddddddd! * splash* Patrick: Yeh were sayin'?"
 * Clive Barker's Undying: "You know what ? You talk too much." * slices off his head*
 * Also:

"M. Bison: Charlie:"
 * The Mark Of Kri ends on something of an anti-climax: as the Big Bad Necromancer makes his We Can Rule Together speech, Rau Utu politely listens for a moment, then reminds the speaker that he has An Axe to Grind.It's awesome.
 * Charlie's ending in Street Fighter Alpha 3:

"Bowser:"
 * A good amount of Bowser's dialogue in any game in which he's not the Big Bad - especially in Mario & Luigi: Bowser's Inside Story - with other villains usually ends with this, mostly out of the fact that Bowser doesn't care enough to listen to anyone ramble on about anything. He even gives a spectacular one to the Final Boss:

"Luigi: Hey! Stop messing around and fight us for real!"
 * It really figures that a Card-Carrying Villain wouldn't really be affected by the usual attempts at rationalisation.
 * Luigi says this to Dimentio in Super Paper Mario:

"Sam: You might wanna work on that "bulletproof" thing."
 * SWINE has an interesting version: Irontusk is about to escape in his zeppeling and he's raving about how he will return and crush the rabbits... until his zeppelin is blown in two by a Genre Savvy rocket tank. Shut Up, Irontusk indeed.
 * The last chapter of Half-Life 2 begins with Gordon hearing the end of a speech Breen is making to Eli about the future of humanity and all the glorious things the Combine can show us. Eli responds with "What I've seen is also beyond words: Genocide! Indescribable evil!", and likely would have continued in that manner had he not seen Gordon was also a prisoner.
 * A player-controlled version comes later when Gordon is fighting through the Citadel. Breen shows up on various screens and loudspeakers along the way, each time taunting Gordon, telling him how he was always a minor presence at Black Mesa, how everything Gordon's done since has caused more killing and destruction... if you as the player are so inclined, Gordon can simply destroy any of these screens or speakers along the way to shut Breen up mid-speech, all without Gordon ever saying a word.
 * In The Godfather game, various enemies will try to give a Motive Rant if you interrogate them. In order to do so, you need to be grabbing them. As a result, after they finish speaking you can proceed to off them however you like.
 * In Splinter Cell Conviction the evil  claims he is "bulletproof" after Sam applies the Jack Bauer Interrogation Technique; Sam responds by shooting out his knees.

"Arl Howe: "There it is, right there. That damned look in the eye that marked every Cousland success that held me back. It seems you have made something of yourself after all. Your father would be proud. I, on the other hand, want you dead more than ever...""
 * A number of games, such as Grand Theft Auto IV allow the player to kill enemies during gameplay, possibly in the middle of a Hannibal Lecture.
 * Final Fantasy VI inverts this. Your heroes go on and on about why people will survive, no matter what Kefka does. And then Kefka says "You all sound like pages from a self-help book." Cue the battle.
 * In Dragon Age:Origins you can scald Morrigan after her especially Stupid Evil attempt at being a Nietzsche Wannabe (sure! Let's abandon the Circle of Magi to death and corruption. It's not like we need their help to stop the Blight), call her a harpy and demand that she shuts up. Naturally, Morrigan disapproves.
 * In a somewhat gentler example, one of your other options in that scene is to tell Morrigan severely that everyone deserves respect...even her.
 * A Human Noble PC gets an even better one when facing down Arl Howe, At first, he mocks you about how he, but then you get the chance to verbally tear him to shreds, basically calling him a coward and showing him that all he's done has only made you stronger and more determined. His reaction is priceless.

"Ultimecia: "Why don't you just give up? The crystals are nothing more than the fabrication of a fallen goddess. To so willingly risk your life over such things is beyond ridiculous." Warrior of Light: "Are you finished talking?""
 * At the end of the Godlimations flash RPG Amea,
 * Fatman, one of the bosses in Metal Gear Solid 2: Sons of Liberty, is convinced that he is a Mad Artist, who will be remembered through history as the greatest bomber and demoman in the world. Raiden interrupts his little speech, snapping "You're nothing but a common criminal, and that's the only way people will remember you!"
 * Dissidia Final Fantasy provides its heroes with a lot of opportunities for these. One of the best examples comes from the Warrior of Light:

"I'll take that as a no."
 * Squall also shuts Ultimecia up twice - the second time with his gunblade.
 * In Portal 2,

"Mao: ...Hmph. I stay quiet and listen, and you continue to blab. It was only you alone that wanted any of this. Was a hero such a dinky existence that you couldn't shine without an enemy? Were you so pitiful that you had to watch out for what the people thought, and be afraid of being forgotten? Is it a hero's job to raise an enemy just to make yourself look greater? Did you want praise for your efforts? Mao: Shut up! You're not a hero, nor human! You're just miserable evil who's clinging to distorted justice! The human world is what you should've been protecting! The moment you stopped, you lost the right to be a hero! "A hero must act with courage to protect that which is precious!" Mao: For those whom you must protect, for things precious to you, a hero squeezes out every bit of courage he has... Yes... A guy like this Almaz is the true hero, don't you think!?"
 * At the end of Sly 3,
 * The sci-fi submarine combat game Aquanox has a pretty funny one. Towards the end of the game, the hero Flint confronts the leader of the Crawlers, the setting's Usual Adversaries. The Crawler Leader gives a big, incredibly melodramatic speech about how he's going to wipe out human civilization and eat everybody. In response Flint simply quips "Soooo... you write your own material?".
 * Before the penultimate story battle in Disgaea 3: Absence of Justice, goes on about how a hero only exists when there is evil to fight, and is useless otherwise. Mao, having sat in the back and listened to the rebuttals of the others this whole time, has finally decided that he has had enough crap.
 * You... ! You dare insult me, the Super Hero?!
 * Huh! That's...!

"Ryu: No reason can ever excuse the destruction and slaughter of mankind. The only thing that's going to get destroyed is you and this dimensional warship!"
 * In Ninja Gaiden 3: The Dark Sword of Chaos, Ryu Hayabusa gives one to after the latter offers him the chance to join him in the destruction of the human race, saying that he just wants to protect the Earth from the damage that human's cause. Ryu's response?

"Junpei Iori: “I'm not dying so you can have a friggin' night-light!”"
 * The Legend of Zelda: Twilight Princess has Zant claiming that he should have been the rightful ruler of the Twili instead of  One ass kicking at the hands of Link later, Midna tells Zant that the reason the Twili didn't go along with him was because they knew he was a power hungry psychopath.
 * Persona 3 saw Junpei cutting Takaya short, as he rants on about how death and the Fall are the light to guide humanity out of the darkness:

"Marcus: This is for and all the others you have killed, you bitch."
 * Nearing the end of Gears of War 3 after  had committed a Heroic Sacrifice and died right in front of his son. Queen Myrrah, defeated, approached the gears and gloated to Marcus how all he had ever done is find ways to kill lots of people. Marcus simply stabbed her and said:

"Marcus: I can live with that."
 * Done earlier in the boss fight if you keep it going long enough. As Myrrah, she goes on a rant that humans are inherently violent and genocidal, prompting her Locust to act the same way to defeat them. How does Marcus react to this insult to humanity? Does he deny it as not our nature?


 * On four separate occasions in Asura's Wrath you have the ability to do this by punching out the guy doing the Hannibal Lecture. For three of these occasions, you get an achievement for doing so.
 * Borderlands; In the final battle with Handsome Jack, it's up to you - the player - just how much of his pathetic rant he gets out before you apply this Trope by blowing his brains out. Most players  aren't going to wait long.
 * Project Wingman: In Mission 18, Diplomat delivers the shut up equivalent of a Cluster F-Bomb to Crimson One when the enemy pilot tries to blame them mercenary dogs for everything.