First Law of Gender Bending

""Once a girl has been created, circumstances will conspire to keep her a girl.""

So you've got the plot all finished, the McGuffin is located, and all of the loose ends are nicely tied. Time to finally reverse that pesky Gender Bender you've been laboring under since the beginning of this story arc. Piece of Cake. This is fiction, after all. Aren't green rocks, Applied Phlebotinum, and magic all abound? All you need do is hunt down Those Two Guys with the Transformation Ray, jump into that magic spring, or run down to The Little Shop That Wasn't There Yesterday for one of their Gender Bender specials. How hard can it be?

Oh, wait -- you used to be a boy, didn't you?

Sorry, sister. Looks like you're out of luck.

Not only are male-to-female Gender Benders a lot more common than their female-to-male counterparts, they are also a lot more permanent. One would think that the same Applied Phlebotinum able to change a male into a female should just as easily be able to do the opposite, but that's rarely the case in practice -- most characters who try to reverse a male-to-female Gender Bender will usually learn that Failure Is the Only Option.

There are many reasons for this, many involving Unfortunate Implications and the Double Standard. And it's not always due to a breakdown of the gender-bending Applied Phlebotinum, either. Perhaps they just couldn't help falling in love with their best friend after they Jumped The Gender Barrier. Or maybe they became a Mama Bear after their Kid From the Future turned up and forced them to embrace their inner Mommy. Maybe they're the only ones who can protect the earth with their gender-based superpowers. Or perhaps, since they were men, they're just that much more deserving of a gender equality Aesop than their wiser Distaff Counterparts. After all, what better way to start (or cap) off a man's Humiliation Conga than to put him in skirts? Unfortunately, inherent in much of this is the assumption that turning into a woman is inevitably a demotion, a punishment or a loss of status. Even the most feminist Take That against men may be (consciously or unconsciously) playing to this stereotype if it uses the "Gender Bender as punishment" motif.

Female-to-male Gender Benders are by contrast relatively rare and usually brief, usually serving to highlight the character's essential femininity. And since Beauty Is Never Tarnished the very same forces that seek to restore her gender will work against him restoring his. And since Most Writers Are Male and All Men Are Perverts there's just that much more pulchritude to go around if she gets restored and he doesn't. (Woo Hoo! Fan Service!) And if it's a Male-to-Female Gender Bender who refuses to act in gender-appropriate ways then so what? Tomboys have always appealed to a broader cross-section of the fanbase than Sissies.

The First Law is often justified by the Status Quo Is God principle. After all, what Gender Bender based Fish Out of Water plot could possibly survive long after it has been stripped of its central premise, or explore Different for Girls when it no longer applies? By the same token, most aversions are also justified by Status Quo Is God. If a work's not primarily about Gender Bender issues, expect the situation to be reversed by the end of the story, probably with a Snap Back and an Aesop about "how the other half lives." Or to put it another way, if the work is a webcomic called The Amazing Girl-Boy's Adventures in Femininity, expect the First Law to be enforced. If it's an episode of a Kid Com called Homeroom Genie where the Jackass Genie turns Zach into Zoe to teach him a lesson? Not so much.

Before you ask, there is indeed a Second Law of Gender Bending, and even a Third Law of Gender Bending. They may or may not overlap with the First Law. Originally known as "Mandy's Law of Anime Gender Bending" after the person who first proposed it.

Anime
"Kyoji: "Thus Guilt-Na obtained the treasure of "friendship", much more precious than becoming a man."
 * Ranma 1/2 observes the law in more than one way:
 * Once Ranma acquires his gender-changing Curse, no attempt at curing it works, at least not permanently. Further, many fans have observed that he seems to attract water (which triggers the change) as easily as fiancées and rivals. However, attempts by other characters at making Ranma permanently female also fail, so this may be less the Law than Status Quo Is God, a common trope in author Rumiko Takahashi's works.
 * The "rules" of Ranma's curse are biased in favor of the Law. "Cold" water will turn Ranma into a girl, but pretty much any temperature below body temperature will suffice. Turning back into a boy requires genuinely hot water. Simply warm water won't do it, so she is usually limited to two options: taking a hot bath or obtaining a kettle of just-boiled water, which Akane seems to supply quite often.
 * Megumi in Tenshi Na Konamaiki has spent six years as a girl at the start of the series, dressing and grooming herself in a very feminine manner.
 * Mizuho in Otome wa Boku Ni Koishiteru not only gets to stay at the girls' school after being discovered, but volunteers to do so. Except for an obscured view of his face early on, we never get to see him in a 'male' persona.
 * The manga shows his face in his 'male' persona, and he still IS cute.
 * Likewise Kashimashi Girl Meets Girl randomly obscures its lead's face until he becomes female, even though he's described as 'girly' to begin with and looks virtually identical. The lead also remains a girl, even though (or perhaps because) two other girls fell in love with her.
 * It's strongly implied that "he" was transgendered all along without realizing it, and that was the reason behind the Gender Bender in the first place. Hell, she even had the same female voice actor during the male phase.
 * The aliens specifically stated that the transformation was irreversible.
 * Inversion: Sailor Starlights from Sailor Moon. They spend significantly more screen time in male identities, to various degrees, with the handwaving that this makes their act of posing as pop idol singers looking for a lost love more convincing. Of course, the show is aimed at girls...
 * Exception: Makoto in El Hazard the Magnificent World gets to stop dressing up as Princess Fatora once the real princess returns.
 * White Haired Pretty Boy Vampire Guilt-Na-Zan of Vampire Doll seems to be doomed to this fate, mainly because the person who transformed him is a Magnificent Bastard. Lampshaded in one of the omake comics:

Guilt-Na: "You're not going to change me back, are you?!""


 * Gacha Gacha Secret has a more understandable case, as the guy is turned into a girl whenever he sneezes, but never even tried to cure it; he just used his girl-form to make friends with the girl he likes to get to know her better. In the end.
 * Inverted in Ouran High School Host Club: the club members conspire to conceal Haruhi's true gender as soon as it's revealed.
 * The fake Mashiro in the Mai-Otome manga coincidently takes the appearance of the young, flat-chested loli character. He's rarely out of drag, perhaps to placate fans with generous dissonance.
 * Played with in Happiness!, where Jun is turned into a girl. He's virtually identical looking anyway, and it only causes lots of magic-related difficulties before he decides to turn back. This might be a simple Shout Out to the original game, where it was related to removing a Road Cone from more openminded fans.
 * Seen progressively in You're Under Arrest. In the original season, Aoi is originally discovered to wear falsies and the animators make a point to be careful about what outfits they put her in. In later ones, Aoi wears virtually anything the standard girls can wear; we only get the fact dropped in the season premieres, and the requisite Once A Season episode starring him.
 * Played straight in Pretty Face. After regaining his original face Randou learns from that he'll need to continue posing as Rina's twin for another year, only to be told by Doctor Manabe that if he had another face-changing surgery he'd be stuck with a girl's face for the rest of his life. I Want My Beloved to Be Happy says he'll go along with it.   So, in the long run he ends up spending more time with the eponymous pretty face.
 * Though.
 * Space Pirate Mito Poor
 * Manga example: Mashiro Ichijo of After School Nightmare was born male above the waist and female below. Mashiro starts out identifying as a male but struggles with his femininity.
 * Averted in Shugo Chara, mostly because.
 * In Birdy the Mighty, Tsutomu is accidentally killed and has to share Birdy's body, although it can change appearance between the two of them. The Decode remake takes it a step farther, when at the end of the first series he gets his own body back, it is destroyed almost immediately.
 * Kampfer's Natsuru, after being turned into a girl to take part in a secret tournament of female-only fighters. He is the only character actually afflicted with a gender change, while the others merely transform into violent alter-egos. The change is triggered in the presence of other fighters, and also at will (once mastered), but Natsuru is very very often forced to maintain his female persona.
 * Played straight on Vandread with

Comic Books

 * In Knights of the Dinner Table, the gaming group is forced by their female fellow player-turned-DM to play as characters opposite their normal gender, causing a great gnashing of teeth by the conservatively oriented, hack-and-slash males of the group. When they finally begin playing, most of the players begin "rolling johns" and otherwise using their new gender as a tool for their usual larceny. However, Bob starts to have a deep affection for his character, to the point of preening his character figure. When the group comes across an artifact that would allow gender reversal, everyone leaps on the chance to have their characters switched to males, except for Bob, who states that he would like to have his character remain female.
 * Mantra, the title character of the Malibu Ultraverse comic, was warrior knight Lukasz, reincarnated in the body of a woman for the first time after centuries of reincarnating into male bodies.
 * Marvel Comics' shapeshifter character Courier took on a female form during a time travel adventure with Gambit, as part of a ruse to investigate Mister Sinister (then acting as an obstetrician.) Sinister learned that his patient was a shapeshifter, and managed to extract that ability for his own use. Sinister (not knowing Courier's true sex) inadvertently left Courier permanently female as a side effect of this process.
 * Mister Sinister himself became subject to the First Law later. After trying to bodyswap with Professor Xavier unsuccessfully, the only available body was a female clone of himself. "Miss" Sinister has since had a fling with Wolverine's son Daken, and is disturbingly attractive considering her origin. However, this character doesn't share Mister Sinister's memories, so it's debatable whether she is "really" him.
 * Alpha Flight demonstrates that while The First Law is powerful, it can't withstand the power of Status Quo Is God. Near the end of John Byrne's run, the body of Walter Langkowski (aka Sasquatch) was destroyed. Under new writer Bill Mantlo, his spirit eventually ended up merging with the body of the shapeshifter Snowbird, who died while in the form of a white-furred Sasquatch. Walter soon discovered that Sasquatch's new "human" form was, like Snowbird, female, and she lived for several years as Wanda Langkowski. Wanda's sex change was only one of several major changes to the Byrne-era status quo, most of which were reverted when he was off the book, and Sasquatch regained both his manhood and his original orange fur.
 * Shade the Changing Man had to take over the body of a drowning woman in order to stay alive himself. Overnight, it reverted to female form and could not be changed back until he found the person responsible for the woman's death. Even after solving that mystery, his female features would re-emerge from time to time until he abandoned the body to fight death on it's own terrain.

Film

 * Goodbye Charlie: a male chauvinist lady killer is killed by his latest conquest's husband, and returns as Debbie Reynolds.
 * Switch: a male chauvinist lady killer is killed by his ex-lovers and returns as Ellen Barkin.

Literature

 * In Mercedes Lackey's Vows and Honor series, the sorceress Kethry puts a rapist under a visual (and tactile) illusion of a woman's body and sends him back to his rapist buddies. Later, a demon puts an end to this illusion -- by changing him into a real woman.
 * Jack Chalker (of course) lampshaded this trope even before it was a trope in Downtiming the Night Side. Once the timestream finds a niche for a nightsider, they become that sort of person in whatever time they leap to. (In the hero's case, a prostitute.) Also shows up in the River of Dancing Gods series.
 * Jack Chalker also wrote The Identity Matrix, in which various characters end up wearing each other's bodies. The narrator, a man, finds himself first occupying the body of an Amerindian girl, then occupying the body of a Canadian college student. Since the authorities can't return him to his original body they decide to rewrite his memory to turn him into a stripper and a prostitute. It Makes Sense in Context.
 * David Weber takes this on in his Safehold series, where the primary protagonist is a robotic duplicate of a young female space-navy officer. When she has to deal with the primitive, male-dominated society that dominates the remains of the human race when she wakes up, she uses the robotic body's nanotech capabilities to turn herself male. And has so far stayed that way through three full books. (An amusing moment lampshades the usual Gender Bender trope when she finds herself with a disturbingly physical reaction to what the originally straight, female character sees as several attractive young men... while skinny-dipping...)
 * In the Wheel of Time series, the Dark One intentionally gives the formerly male Balthamel a beautiful female body as Aran'gar. Getting a body for reincarnation is difficult in the Randland universe, so Aran'gar's choices were either to remain stuck with a woman's body, or die. Again. Being a Depraved Bisexual, Balthamal / Aran'gar was more startled than upset by her change.
 * In Robert A. Heinlein's I Will Fear No Evil, the rich old cotter protagonist pays to have his brain implanted into a fresh young body in order to cheat death. The first matching donor to come up is a woman. When he comes to after the surgery, he thinks about this a bit and decides it's worth it to see how the other half lives. Seeing as how his surviving the first transplant was a miracle, his situation is pretty permanent.
 * Enforced and Played for Drama in Judith Tarr's A Fall of Princes: The two male characters are more than half in love already, the best solution for solving the conflict between their nations is a Perfectly Arranged Marriage, same-sex marriage is not an option, and the required magic ritual is explicitly irreversible.
 * Played straight and justified with a Gender Bender in S.L. Viehl's Dream Called Time: While  seemed to be more-or-less okay with the idea of the Gay Option,  did not want to look like, and switched back  as soon as an opportunity arose.

Live Action TV

 * This is the premise behind the Toku series Seishoujo Senshi Saint Valkyrie, as well as the webcomic that it appears to copy, Sparkling Generation Valkyrie Yuuki. (See this SGVY blog post for a discussion and video.)
 * La Lola is a telenovela that originated in Argentina, and has been adapted in many other markets. Most of them deal with this trope:
 * In the Argentinian and Spanish versions, Lalo tracks down the witch who turned him into a woman, and she agrees to turn him back (after laughing for a while). They hold hands, she starts her mystic chanting... and promptly falls backward, dead.
 * The Chilean version gets way more convoluted, as both Lalo/Lola and Pepa/Pepe can't get back to normal and when that happens it's just for a few episodes. In later episodes, there are two Lalos or Pepas thanks to the later-added conditions to the spell.
 * In the Wingin It episode "I, Carlie", Angel-in-Training (AIT) Denise agrees that Carl, now Carlie, has learned her lesson, and agrees to turn her back into Carl, but finds she can't. The AIT handbook explains that he cannot go back to being a boy until he truly understands girls.
 * Goodbye Charlie, a sitcom adaptation of the movie of the same name (which was itself based on a play) starring Suzanne Somers as 'Charlie'.
 * Subverted in Degrassi when Adam, an FtM transgender already living as a male when introduced, detransitions once before reverting to his male persona within the episode and burning his last remaining girl clothes.
 * Averted in Wizards of Waverly Place -Max spends a few episodes as Maxine, but returns to normal eventually.

Theater

 * The movie and television versions of Goodbye Charlie were both based on the 1959-1960 play of the same name. With Lauren Bacall as Charlie.

Video Games

 * The protagonist of the X-Change Dating Sim series. Changing back to male and getting the lead girl appears to be the "canon" ending, but he gets turned back into one each game. The last game actually states that changing so will soon make him permanently female.
 * X-Change Alternative varies depending on which ending you get, normally depending on the preference of whoever you happen to be dating. One of the more bisexual girls gives you a choice however. You're also a different character in the next game, so no ending is "official".
 * Both played straight and inverted in the Dating Sim Kuru Kuru Coeur, in which the three originally female love interests all become male at some point, two staying that way half the game, and all four datable characters have one ending for each gender with the main character changing to match. On the other hand, the originally male main character and his (dateable!) best friend spend 90% of the game as girls and have disturbingly large male fan clubs to boot.
 * Breath of Fire 2 has a very interesting case, where the "circumstances" referred to by the Law means the player. Since  is a significantly more useful party member as a girl (but loses the transformation if knocked out or zombified in battle), the average player will try to keep the character from losing the transformation if at all possible.
 * To clarify for those who aren't entirely familiar with the game: most of the playable characters can Unite with Shamans (essentially merging with them) to receive stat bonuses and, with specific combinations, a significant change in appearances and powers. Also note that  and has an effeminate, asexual appearance normally.
 * Considering that 's two other combination forms are an onion with feet (I kid you not) and a plant-like dragon he may be a she to begin with.
 * In Fable II, there is only one gender reassignment potion in the entire world, and it's permanent and irreversible.
 * In Baldur's Gate 2, Edwin Odesserion ends up as a woman after using a scroll he thought would turn him into a lich. While he does manage to turn back in a guy later in the game, in the epilogue an encounter with Elminster turned him back into "Edwina", who's now a barmaid (later ending up in Ferelden somehow) and a "bitter, bitter woman".
 * Becoming a woman is a possible effect of a scroll mishap in D&D 3.0, so s/he may have found an actual lich-turning scroll and just messed up during the casting.
 * Averted in MU Ds, where one of the standard status effects is a Gender Bender (which really doesn't do anything in-game except change your pronoun), which affects both genders equally and wears off in a few minutes.

Web Comics
"Aimee: "Seriously, Anne, don't ruin this for me.""
 * Misfile, as shown in the trope image. Not only does Ash seem to have a better life as a girl, nearly everyone he and the angels have come in contact with since the misfile seem to have had their lives improved in some way. Which hasn't stopped him from wanting his male body back, but as things stand, it's going to be a looooong time before that happens.
 * Sailor Sun. Despite Transformation Rays being mundane (albeit prohibitively expensive), the Kid From the Future has a tendency to call the main character "Mom," suggesting that she never changes back. The author has theorized that these tropes appeal to people due to the humbling effect inherent in a male-to-female transformation in our male dominated society.
 * The Wotch: how much Anne loves to turn her male friends into girls is Lampshaded frequently but the tendency seems to extend to everyone with the appropriate powers. Over the course of the strip many, many characters get their gender bent but it's only the formerly male ones who fail to get restored. (Even the straw feminists of D.O.L.L.Y., who arguably earned kharmic punishment, get turned back into girls in the end.) The strip seems to delight in finding reasons why former men can't or shouldn't be turned back, even though given Anne's powers and general benevolence it ought to be easy. There's even a spin-off (The Wotch: Cheer!) comic about four of its permanently genderbent characters.
 * Also, in the years before the DOLLY arc, though, as stated, male-to-female changes were constant and many were permanent, female-to-male changes never happened except for an oft-bodyswapped couple. One time we thought Anne and Miranda had become boys, but it turns out Wotches cannot be male and so Anne and Miranda are immune to genderbending.
 * Lord Sykos shows up and goes on a gender-changing spree across town, happily encouraged by his first victim "Aimee". At the end of the story arc he turns all his victims back to normal except Aimee who decides she prefers being Sykos' Perky Female Minion to her former existence. As we don't get to see much of "his" life before the transformation we're given no real motivation for this decision.

"Where am I? Why do I have tacos? ...And why am I a girl?"
 * There was also one unnamed guy girl who Lord Sykos sent to get tacos who had the misfortune of failing to return before Lord Sykos restored everyone else and returned to his home dimension, leaving him her with no memory of the incident...and a lot of unanswered questions.

"Durkon: Roy, before I cast tha spell, are ye absolutely sure ye want to go back to being a man?
 * El Goonish Shive, while not as casual or frequent about it as The Wotch, certainly pays the Law its dues. According to the rules governing the comic's main sex-changing phlebotinum, only male-to-female sex changes can be made permanent (via pregnancy); female-to-male sex changes, even of someone trapped by pregnancy (for whom it's only even possible afterwards), cannot exceed a 30 day time limit. The second time a boy - the main character - is turned into a girl the device breaks, leaving "her" stuck for the full thirty days, and the attempt to get around this leaves him with an Opposite Sex Clone and the permanent ability to change sex at will, something the rules of magic eventually force him to do on a regular basis.
 * Also, much later, a "seyunolu" (chimera) member of the Quirky Miniboss Squad, Vlad, is hit with a Transformation Ray and is turned female, but more importantly to him/her, human. "She" has no desire to change back, and since Bizarre Alien Biology overrides the time limit (and, implicitly, gender identity), Vladia, as she is now called, is treated as a woman from then on.
 * Moving on from Elliot being a double victim of this, we get to Tedd. Who probably wouldn't know this was a law: the 'circumstances' usually equate to 'Dad's out of town' and 'As a girl, I'm hot'.
 * Sparkling Generation Valkyrie Yuuki. (See also Seishoujo Senshi Saint Valkyrie, above.) goes the gender-based superpowers route.
 * Abstract Gender - The guy who has no problems gender changing can change back and forth at will, the guy who hates it is stuck permanently.
 * Triquetra Cats started the comic this way, but soon delegated it into a minor plot point in favour of a more complex storyline - a new reader not starting at the beginning might take some time to realize they were ever boys.
 * In Discordia, it's established that anyone transformed by a virgin winds up the virgin's gender; this is true whether they started out that way or not (for instance, a man neutralized via Fountain of Youth ends up as a little girl). Since the only character with such powers is a prepubescent girl, the male cast members had better watch their step. Furthermore, the formerly male main character can't be transformed again at all.
 * Defied in this Order of the Stick.

Roy: What? What kind of a dumb question is that?? Look, I'll admit it wasn't as bad as I'd feared. I wasn't any weaker or anything. I did have trouble keeping my emotions under control, but I think that was because I'm not used to the hormones. But come on. I was born a man, there's no reason I would want to stay a woman."


 * Narbonic examples:
 * Averted in the Gender Swap storyline, Helen spends a full week of strips male before Dave is turned into a woman, and they switch back simultaneously.
 * But once that can of worms was opened, they never could close it again. Dave may not remain a woman permanently, but they transform on many occasions, particularly . It is treated less as a plot point and more as a "thing mad scientists do", along with drugging the coffee and breeding super-gerbils. Also, . He's even aware beforehand that it's how things will likely come to pass, given that Helen's a mad scientist.
 * Jayden And Crusader referenced, and subverted, this trope twice, and eventually did swap the gender of its most masculine character. However, that was reversed moments afterwards thanks to his excedingly violent nature. As the entire event was designed for the purpose of gaining readers the trope has only ever been jokingly entertained.
 * The initial arc of The Dragon Doctors tells how all five doctors - four male and one female - are transformed in an ultra-permanent way. When they've all gotten used to it, the one woman is suddenly turned back in an accident that can't be duplicated for want of a rare and powerful bit of Phlebotinum, leaving all five female - Goro, the one most bothered at first, stated an unwillingness to turn back even if it became an option.
 * In DDG Netta seems to enjoy keeping Zip a girl far too much to let him ever change back.
 * In MSF High, Nurse Keiri seems to have made it her mission to warp the gender ratio as much as possible. Everyone who gets more than bandages from her leaves female. At the end of the day, anyone who's been transformed in any way can change back totally or keep all aspects of the new form, forever; with this in mind, she also tends to give incentives not to change back. There's nothing to stop people who have been changed from being changed again, but (other than the daily Reset Button) female-to-male is rare, and never seen in the comic seen once so far and will probably be reversed, where so far at least three significant characters (Urk, Collete, and Victoria) have gone through this progression and are now female for good.
 * Also, the Legion are a fairly benign version of The Virus; the victims, who seem to have been mostly male, keep most of their personality, but become unquestioningly loyal literal Green Skinned Space Babes. In the main setting, this is as temporary as anything else (although like Keiri, they put some effort into retention), but in most of the galaxy, it's irreversible.
 * Note that Legion T Fs are only irreversible outside of MSF High because of the lack of transformation magic in Mahou Galaxy. Tends to be all over the place in the Forum RP, as well.
 * In the first comic of I Dream of a Jeanie Bottle, the main character Jean is turned into a female genie that looks very similar to Barbara Eden from the TV show. While Jean (aka Jeanie) attempts to understand her new powers, she has yet to find a way to turn herself back into a male.
 * A running thread in Slipshine's Momo Impact is the queen of a planet of lesbians - any male of any species that gets within a few centimeters of her instantly and irreversibly becomes a beautiful humanoid woman.
 * Also, in The Key to Her Heart, a Gender Bender, who had been distinctly male, falls in love with a lesbian, leading to him spending nearly all his camera time female.
 * In Exiern, the main character is a barbarian warrior who gets turned into a woman. All his attempts to get turned back to his original gender fail or backfire. At one point, the clerics who were attempting to undo the spell end up turned into women themselves.
 * Surprisingly, the latter part turns into an aversion of the trope. The clerics perform a reversal spell, and it works... for all of them except the one who obviously loved being a girl, and she obviously refused to reverse her own gender. Though one of the clerics that became male again, turned female again after sneezing. Probably implying that their return to manhood is short-lived
 * It does not look good for Tiffany, the results of of consulting a magic encyclopaedia about a cure is just 3 pages of mocking laughter, in text.
 * In the Jet Dream remix comics, the biological weapon Virus-X changes the T-Birds of Thunderbird Squadron into the T-Girls of J.E.T. D.R.E.A.M. The T-Girls are able to de-feminize the male population of Miami Beach after a terrorist attack, but the antidote is ineffective after 24 hours, and thus cannot help them personally. Only one person is shown to believe Virus-X to be potentially reversible, and she's an insane Psycho Ex-Girlfriend. A voluntary treatment based in some unspecified way on Virus-X is also portrayed as irreversible.
 * In the photographic novel, Little Worlds, the part of Lev (a male character) is played by a female actor, leading to questions about Lev's gender identity.
 * When Blair runs amok with the Tiresias Orb in Eerie Cuties, the only major male character affected is outside getting an unconscious boy some fresh air when the orb is destroyed, unleashing a World Healing Wave on everyone inside the school. He's eventually changed back, but not before spending about two-fifths of the strip's run with his fate in the air, and only by inadvertently transferring it to another important boy, who likewise spends several chapters with his fate uncertain.
 * In the webcomic Ballerina Mafia, a character's friends give him an Easy Sex Change in his sleep as an April Fool's day prank. He decides to just start living life as a girl now, and was more annoyed than anything by it at first; ultimately, when she's given the chance to change back with no strings attached, she declines.

Web Original

 * Whateley. Just Whateley. If someone is turned into a girl and used to be a guy, no force on Earth can fix it -- literally so, as there's a goddess involved. Maybe. It has been hinted that the scientists that came up with this theory -- that there's a force of evolution forcing mutants to out-breed humanity -- may or may not have been wrong. Ironically, the few characters turned into guys also have trouble fixing it, or don't try. It's just about standard to say that it's easier to cause a transformation then fix it. (See The Big Idea, a Single Fold, and ALL of the Team Kimba stories.)
 * Heavily subverted in the character of Jade. She has trouble finding a way to transform herself in the first place!
 * Even appears to be occurring to Phase, who is resisting with all his might the other two. However, it's not certain that it will end up like this, as Phase is still looking through 'outs'.
 * SCP Foundation: (SCP-767 is an artifact capable of transforming males to females only. SCP-113 can go in either direction.) "Experiment Report #113-4: Testing with subjects sex-changed by SCP-767 shows that SCP-113 cannot reverse the sex shift. So far this is the only known case wherein SCP-113 cannot induce a sex change."
 * Two of the first main characters on The Trading Post were hit with this with different results.  There have been a couple notable aversions, including
 * In the Paradise setting, humans are randomly, permanently changed into Funny Animals (with some experiencing a gender-change at the same time). Except for the very few who experience additional changes once per year (and thus have a chance to change genders again), these changes are permanent.
 * Very common on Literotica when a sex change is involved.
 * Expect the vast majority of stories on sites specializing in Gender Bender and/or Cross Dresser stories (e.g. Fictionmania, Crystal's Story Site, and Bigcloset Top Shelf) to follow this trope.
 * Spells R Us stories typically involve the purchase of items that change a person's sex from the shop's wizard proprietor. Invariably, the change ends up being a permanent one, because SRU is The Little Shop That Wasn't There Yesterday.

Western Animation

 * Subverted in the French short film Geraldine (NSFW for cartoon boobies). The main character is a man who turns into a woman. It seems like it's going to stay that way, and as soon as he figures out how to live as a woman, he turns back into a man.
 * Subverted in Futurama in the episode "Neutopia". At the very end, Scruffy appears to be irreversibly trapped as a woman, but in the next episode he is back to normal.
 * Earlier though, when the group asked the alien who reversed their genders to fix things, he's ready to go along with it...except Zapp Brannigan chooses that moment to leap in and melt the alien into a puddle, trapping everyone in their swapped genders until the alien's friend comes at the end of the episode to make things right.
 * Subverted in South Park. During the premier of season 9 Mr. Garrison had a sex change to become a woman, and he stayed that way for three years, at least until season 12 rolled around, when he/she got another sex change to become a man once again.
 * Subverted in Fairly Odd Parents, where Timmy gets turned into a girl for one episode (and Cosmo and Wanda also switch genders), and everyone gets changed back at the end.

Real Life

 * Male-to-female sex reassignment surgery is easier to perform, and more closely matches the target sex, than female-to-male sex reassignment surgery. From a tissue-manipulation perspective, it's simply easier to make a convincing vagina out of a penis than the other way around.