Survived the Beginning

Often in the first chapter or story arc of a series, Anyone Can Die. The main characters are not established yet and so when someone dies it is quite surprising since everyone was given equal character development. Of course, the death of friends and family motivates the survivors, who go on to become virtually immortal from there on out, not suffering a casualty ever again, except in the most highly dramatic way.

The inverse of Sacrificial Lamb. Will usually result in a First Episode Spoiler.

Anime

 * In Elfen Lied, many an anonymous guard is violently killed in the opening sequence, but surprisingly enough, so is the clumsy-but-lovable secretary Kisaragi, who you would've thought was well on her way to being a developed character.
 * In Outlaw Star, "Hot Ice" Hilda appears to be an important character at the beginning of the show. Unfortunately,

Comic Books

 * In X-Men, Thunderbird was killed off in the issue after he joined the team. All other X-Men involved either are still alive or have failed to stay dead.
 * Uncle Ben was killed off in the first appearance of Spider-Man and has remained largely dead. Meanwhile, Aunt May has managed to even come back from the dead. Apparently, Spider-Man forgot to ask for his uncle back when making his deal with the devil.

Film

 * Transformers the Movie: Tons of established characters are killed off in the first battle but from there on out no one can permanently die.
 * In the opening of the first Mission Impossible film, Ethan Hunt's whole team is killed off, including characters played by big-name actors Jon Voight, Kristin Scott-Thomas, & Emilio Estevez.
 * , but you don't find that out until later.

Live Action TV

 * Original Battlestar Galactica Classic: Billions are killed in the Cylon attack but once safely away, the fleet manages to avoid substantial losses for quite a while.
 * Interesting note: in the reimagined series, Helo was supposed to die, having been left behind on Caprica, but the fandom took a liking to him, and he showed up in the series as a main character.
 * Red Dwarf starts with the death of the entire crew of the spaceship, but one. This first episode is appropriately called The End.
 * In Stargate SG 1 Kawalsky seems set up to be a main character, but dies at the end of the second episode.
 * Star Trek Voyager half the crew dies right at the beginning of the series. The never lost more than a handful after that unless there was a reset button handy.
 * Almost everyone who survived the first season of Heroes became virtually immortal in season 2 and after. The characters introduced from the second season on weren't that lucky.

Web Comics

 * Goblins: A whole goblin raiding party is wiped out killing many, many characters. Since then the survivors have gone on to slaughter anything that looks at them the wrong way.
 * Order of the Stick: Half the Linear Guild was lost the first time they met the OotS gang. Since then, the three survivors have consistently made it away while their newer members tend to get Put On a Bus or killed. (Though other characters have not been so lucky, notably .)

Video Games

 * While the Player Character of Dragon Age: Origins can't get killed other than by a standard Game Over during the first two major missions (Origin and Ostagar), his/her Player Party members can and will, so don't grow too attached to them. A case in point: in the Human Noble Origin,  in Ostagar,  in the first mission of Awakening. While your companions may die later in the game, it is always a properly foreshadowed event.
 * Straight and Subverted in Dragon Age II.