Yu-Gi-Oh! VRAINS/WMG

When the show gets dub some of the characters will have Dub Name Change
"Yusaku Fujiki" will be renamed to "Yusaku Wystaria" and "Decode Talker" will be renamed to "Conversation Digiton". His "Charisma Duelist Codename" will be changed from "Playmaker" to "Prince of Games". "Aoi Zaizen" will be renamed to "Sarah Hollyhock" and "Trickster Holy Angel" will be renamed to "Trickster Shining Queen". Alternatively she will be renamed as Zoi since the other heroines dub name are similar to their orginal name Aki-Akiza,Kotori-Tori and Yuzu-Zuzu

"Go Onizuka" will be renamed to "Muscles Colossus", "Gouki Suplex" will be renamed to "Gouki Knockout", and "Gouki the Great Ogre" will be renamed to "Gouki Emperor Ogre". There will be a common joke about how "Muscles Colossus" sounds more like a duel monster name than a human name. Because of this, his "Charisma Duelist Codename" will also be "Muscles Colossus" rather than "Go 鬼塚".

VRAINS will be Darker and Edgier and Bloodier and Gorier than other [[Yu-Gi-Oh]] anime
Think about it VRAINS is a scientific and cyberspace anime and has more science than other Yu-Gi-Oh anime especially Yu-Gi-Oh! 5D's. Cyberspce anime always tend to be darker and serious so VRAINS will likely have a dark and a serious tone.Their will be somany violent and blood scenes and we get to see characters bleeding often.

Link Summoning will get Mid Series Upgrade
Similar to Accel Synchro, Chaos Xyz Evolution, and the various Pendulum subtypes, a new, more powerful type of Link Summoning will be introduced about halfway through the series. Possible mechanics for this include having a Link which exceeds the standard maximum value of 8 (perhaps by having the Link markers change color) or having a special summoning condition which makes them easier to bring out with fewer monsters.

There will be a duelist who falls in coma
The Big Bad and his minions will have the ability to steal souls, like usual, and leave the duelist's body in the real world an Empty Shell.
 * Almost confirmed Blue Angel did fall in coma after her duel with Playmaker instead of having big bad stealiing her soul she was brainwashed by Specter and after her defeat she fell in coma

The villains of this show are Player Kill
And this time, anyone can be Killed Off for Real in the most horrible way instead of being carded. Bonus points for recapturing the charm and nostalgia of the original manga.

Aoi will be Brainwashed and Crazy at some point by a Big Bad or his minion
These is common for every female leads in Yu-Gi-Oh franchise.All of them got brainwashed by the Big Bad of their shown at some point.Since Aoi is the main heroine of this show she will have her mind and body controlled by the Villain or his subordinates only for Yusaku to come and save her and return to her normal sautes much like how Anzu got brainwashed by Malik,Asuka got brainwashed by Saiou,Aki got brainwashed by Divine,Kotori got brainwashed by Girag and Yuzu got brainwashed by the Doctor.
 * Confrimed she got brainwashed by Specter. Unlike the other heroines she got brainwashed so early and after being freed she did return back to normal but she ends up being in coma.

VRAINS will be connected to arc v universe
It will be calLed Link Dimension

There will be a popular IdolSinger in the Link VRAINS realm
Not just an idol, but a Charisma Duelist, too. Expect Insert Song.

Go will have Jojo references
That guy looks like a pillar man. I can't be the only guy who thinks that.

The past incident that Yusaku is pursuing just is him trying to find his father.
This has become a common theme in the franchise lately where the protagonist thinks his dad is the greatest person in the whole wide world only for them to disappear without a trace. Yusaku's entire journey is basically him asking the villains if they have seen his dad, because he believes that they are ones who kidnapped him because he will be of great use for their evil plans. "Yusaku: "I gotta find out who's seen my dad." Ryuko: "I gotta find out who killed my dad." Yusaku: "Let's work together!" Ryuko: Okay, let's see how well you fight. Both: "Well, this is awkward.""
 * Or maybe...
 * Yusaku pulls out his deck, Ryuko pulls out her scissor blade*

Yusaku will have to deal with a duelist that uses the old rules, and/or the Knights of Hanoi will restore the old rules.
This will force Yusaku to overcome a field full of Extra Deck monsters, with only his Links and maybe one or two other Extra Deck monsters of his own.
 * This could basically turn the Knights of Hanoi/that Duelist into a TakeThat towards the fans of the card game who quit after the new rules were shown.
 * Jossed. Their leader, Revolver, uses Link Monsters.

Revolver's real name is Setsuna Saiba
Think about it: Yu-Gi-Oh! Seto Kaiba = Setsuna Saiba
 * Saiba is a pun of "Cyber", and Revolver is the first ever Kaiba Expy who is introduced as a completely villainous character.

VRAINS is connected to ARC-V
The cyberspace is created by Reiji after an accident that rendered Yuya incapable of participating in an Action Duel anymore. He let Yuya (and possibly some close others) test it out and Yuya suggested Reiji to release it to the public.
 * Depending in the mechanism at work, it would also let Yuto, Yugo, Yuri, Ruri, Rin, and Serena move about on their own, as well.

The Mysterious Lifeform will be a sort of companion to Yusaku, similar to Astral from Zexal
He does have a voice actor, meaning that he will have dialogue. He may encounter Yusaku and befriends him, giving Yusaku advice in Link VRAINS.

The True Final Boss and real Big Bad will be The Mysterious Lifeform itself
...thus delivering a TakeThat of epic proportions to the previous series which ran on the concept of the mysterious companion to the main character.
 * If that were happen, we'd inevitably get tons of CounterpartComparison to BitchInSheepsClothing Kyubei from Puella Magi Madoka Magica. Perhaps even a CrossoverShip.

Yusaku and Revolver are related
In this case we could have at least these 3 scenarios:
 * They are brothers. Due to an incident caused by SOL Technology, the two were separeted at a young age and either or both of them suffered Laser-Guided Amnesia, or merely partial memory loss due to trauma. Now they are both seeking the key to their pasts, not just Yusaku. Revolver either thinks he will somehow restore his past memory by destroying Link VRAINS, or is actually doing it out of Revenge as he only knows he has lost his memories, but gave up on trying to restore them (meaning he doesn't remember Yusaku).
 * Now remember all those Kaiba Expies and their younger brothers. It would certainly be delicious to see a dynamic like that if the TheHero played that role too.
 * The YaoiFangirls would be pleased, wouldn't they?]]
 * They are step-brothers, half-brothers or distant cousins and they were separated like described above.
 * They are first cousins. This could be the most interesting way to do it. After all, in most Japanese works of fiction (first) cousins are almost always a boy and a girl who have/seem to be having romantic feelings for each-otherand are otherwise almost non-existent, at least in terms of plot relevance and screen time. Cousins of the same gender who actually have both screen time and plot relevance only appear in the few rare exceptions

The Millennium Items/Shadow Realm will play a role in the plot.
In the first opening, we see the Eye of Horus for the first time since GX. As a result, it isn't too hard to think that some aspect of the original series will make an appearance in VRAINS.

When the show gets dubbed, the dub would air on Disney XD.
If Disney picks up the rights to this show (as well as the rest of the anime series within the Yu-Gi-Oh! franchise), the dub would air as part of Disney XD's anime block.
 * However, Disney has yet to mention anything about the Yu-Gi-Oh! franchise, so fingers would be crossed and we'll see how this plays out. And considering that the show's tone is Darker and Edgier than Yu-Gi-Oh! ARC-V, it's possible that Disney might want the dub to be edited for broadcast on Disney XD if they pick up the rights.

Birds will play a role
We see birds in the opening a few times: when the circles turned to birds that became the title card, then when Yusaku (and Naoki) first appear and we close off by watching a bird fly away. In episode 1, when Shoichi was telling about the Data Storm, we saw an image of...something with bird-like creatures. Not sure WHAT the bird means (is it connected to the more then likely mysterious power in Yusaku, will it be an organization name/symbol, etc.), but in someway it will play a part.

The first duel between Yusaku and Revolver will be interrupted
It's been a staple of the series since GX that the first duel between the protagonist of a Yu-Gi-Oh series and their rival would end up being interrupted, so it's not hard to think this will also be the case here. Especially, since Yusaku losing means that the Knights of Hanoi would obtain Ignis and since that's not an outcome SOL Technology would want, they'd have a reason to make sure Playmaker doesn't end up losing against Revolver.

The Revolver that attempted to banish Cyverse five years ago is not the same Revolver as in the present show.
Since at least two Knights of Hanoi so far have used the same avatar, it makes sense that it would be possible for the Revolver avatar to be shared as well. It could even be a Dread Pirate Roberts situation. Relating to which...

Revolver (or at least, the current Revolver) is Kusanagi's younger brother.
When we see Revolver (or rather, the person using that VR alias) come out of Link VRAINS into the real world, the silhouette of his hair looks similar to Kusanagi's, as well as the brief glimpse we saw of Kusanagi's younger brother. Said glimpse, seen in Yusaku's flashback, could well be from around the same time as the other flashbacks he has alongside, in which Yusaku is much younger - if that was the last time he saw Kusanagi's brother, there could well be time for him to go off and join Hanoi.

Yusaku was once a member of the Knights of Hanoi.
Yusaku was a member of the Knights of Hanoi, until a hack gone wrong seriously injured/killed Kusanagi's younger brother, after which Yusaku decided that this wasn't what he signed on for.

There will be a duel that has Yusaku getting a bumb draw from a data storm
He could still win, and the card can still be useful even in future duels, but it will be worthless or inconsequential in his current duel or he will have to pull a combo to win the duel using that card's effect.

Ema Bessho is the assassin for SOL Technologies
Because Revolver mentioned he thought Playmaker might be SOL Tech's assassin, that implies it's normal in-universe for large companies like that to have one. Plus Ema was very interested in dueling Playmaker, and Akira has to tell her that she isn't to hurt him- which implies that she normally does just that to her targets.

The Data storm Link cards respond to Yusaku's desires
Yusaku will instintively create link cards that will help him overcome his current predicament due to the nature of the "storm access" skill. The cards he creates will always skew towards what he needs as a side effect of it's design. It's like that one spider kid that was one of the antagonists in the Zexal manga who manipulated his personality to control what his number cards become.

VRAINS Isn't technological in nature, it's magical

 * A nice twist on the prevalent science themes of this season may be to reveal that VRAINS actually runs and/or is made up by magical elements that are being controlled by programs instead of being programs in of themselves.
 * The Cyberse is under no ones control, and as far as we know it has no known creator. it just... exists. The Data Storms are also inexplicable; when Cyberse was sealed off, they just disappeared, and no one could re-create them. It's possible that the Cyberse is naturally occurring, and magical in nature, and Link Vrains was built around it using methods analyzed by SOL Technologies.

Yusaku will learn to use the older Extra Deck Summoning methods
As unlikely as this may seem, it'd still be cool regardless to see him utilise Extra Deck Summoning methods other than Link.

Revolver is the one who motivated Yusaku as a kid.
Episode 11 shows that "the one" is who taught Yusaku to keep thinking of three things to keep himself going. Revolver himself makes a list of three in one episode and seemingly recognises Yusaku's speech pattern at the end of episode 12. Assuming Revolver is of a similar age to Yusaku as his real world appearance suggests, he would have been a kid at the time too, which is what Yusaku heard.

A large portion of the Knights of Hanoi are Vietnamese
I mean, Hanoi is the capital of Vietnam, after all... so would it be surprising if some of its members happened to hail from Vietnam?

Akira will have a plan to have Aoi befriend Yusaku.
He would specifically name drop him as the one who found her after she slipped into a coma on the roof of the school.

Playmaker will fight against an AI version of the Pharaoh.
Sometime during his exploits in Link VRAINS, Yusaku can end up uncovering and dueling a data version of Yami Yugi that Kaiba created in Dark Side of Dimensions. After an epic battle, Playmaker defeats the AI and becomes a legendary duelist if not the King of Games in part of his victory against the Pharaoh.

Yusaku is part Irish
His distinctive green eyes, blonde and orange streaks of hair in VRAINS, and, just slightly, maybe his streaks of pink/magenta in the real world give him an Irish look. Also, while he might not be loud and/or boisterous, his blunt, 'I don't care about this, you, or if I insult/hurt you', and slightly righteous personality, again, seem very Irish.