Rise of the Planet of the Apes/WMG

Madagascar is the only place spared the virus.
Cause, A) if they're going to go down similar paths to the original humans have to come from somewhere, and B) who can resist the Pandemic 2 joke? "President Of Madagascar's Aid: "Sir an Airplane pilot in America has a bloody nose." President Of Madagascar: SHUT! DOWN! EVERYTHING!"


 * Madagascar doesn't have apes, or any monkeys for that matter - it has lemurs.
 * And the Lemurs will gain sentience from the virus and build a society and sing "I like to move it move it!"
 * The lemur-ruled Madagascar might become an independent nation, and not be part of a worldwide ape government.

Rodman will find a cure for the plague but the side effects will be loss of speech.
That seems to be a logical way for humans to lose the ability to speak in any potential sequels.

- or, the plague itself causes loss of speech? It's seen to affect the throat.

And the people who don't lose their speech become horribly scarred mutants.
 * And they'll also have albinism and live in LA where Taylor will become a biologist and fight them.

Humans with at least a certain level of mental handicap will be immune to the 113 plague
This starts a downward spiral in the surviving human population until, eventually... y'know. I like to think that Rodney the kindly-but-slow zookeeper gets a happy-ish ending.

Koba will be the ape that causes them to enslave mankind

 * He somewhat resembles Thade from the 2001 film. In the sequel, he might take on the Aldo role, like in Battle for the Planet of the Apes.

Caesar gets his mate in the sequel
One of the chimps shipped off to GenSys is named Cornelia, and he takes a meaningful look at her empty cage before laying siege to the facility. I think there's a deleted scene of them looking into each others' eyes, but that could be completely off-base.

The company that was developing 112 is Oscorp
Why else would Harry be one of the researchers?

Hunsiker never caught the plague
Nah, that was just a nosebleed.


 * Then how exactly did the plague start if he just had a nosebleed? From the landlady who found Franklin dead in his bed?
 * There was no plague. They just felt like showing us a globe with yellow lines to indicate who Hunisker meets, and who all those people meet. It was to show how united humanity was. Touching really.
 * Of course, it all makes sense now!
 * I support this theory.
 * That makes it Big Lipped Alligator Credits!

This takes place in the same universe as Limitless
In Limitless, there is a drug that enhances your brain function, making you become hyperintelligent. Sounds exactly like the drug they gave the apes. Since the Limitless pills didn't kill you, they must be the earlier drug, the 112 that some other lab technician (there's other people working there besides Franklin and Rodman) that decided to sell the drug on the streets.

Jacobs survives the fall.
Not only that, but he survives the plague, which instead mutated him. He becomes the leader of the mutants. He'll develop a deep hatred for apes, much similar to Governor Breck from Conquest of the Planet of the Apes.

In the sequel, Koba will betray Caesar.
Caesar's stance is to not kill humans and just stay out of the way in their own land. Koba doesn't want that, he want revenge. He will betray Caesar to take command of the apes and go to war.
 * I don't think he will physically betray him. Caesar will most likely just die of sickness, and Koba will take over in a dictatorship. Mimicking the rise of Joseph Stalin after Lenin's death. Koba was even Stalin's nickname!

Ape society...
Will develop similar to the apes in the original novel. With large cities and Steampunk-like vehicles.

Their (main) religion will be a mixture of Christianity and other bits of various mythologies. They worship a God-like being similar to Semos from the 2001 film, who created "the ape in his own image". The Lawgiver would be a well-known prophet, a la Moses and Muhammad.

The human survivors of the plague will be the ones most susceptible to Alzheimer's.
The new serum/virus was based on the original, which had positive effects on Alzheimer's patients. The new serum/virus kills people, but maybe its effects are less severe on people who have, or who are likely to develop, Alzheimer's disease. The mentally deteriorated humans in the original movie will be their descendants.

The next movie will involve Caesar attempting to rescue Will from the 113
Because this plot point NEEDS RESOLUTION, DAMMIT.

The next film won't follow the first chronologically, it will be in the distant future.
Lost astronauts. They get back to Earth. You know the rest. Except for one small detail...

The "They blew it all to hell" Statue of Liberty scene will happen at the beginning of the sequel.
Since it's hardly a surprise anymore, but, goddammit, it's so iconic it has to happen. The lost astronauts from the Mars expedition come back and realize right away they're on Future!Ape!Earth and the plot goes on from there.

The idea that humans actually are apes will be a dangerous heresy in Ape society.
Pop biology quiz, which species is the closest relative of chimpanzees? Gorillas? No. Orangutans? No. Yep, it's Homo sapiens. Which would boost another dangerous idea, namely, that apes are in fact Not So Different from the evil humans. Expect the returning astronauts to be (even more) persecuted because they spread this idea.
 * Bonobos, actually. Chimpanzees and bonobos split off less than a million years ago, while humans split off from the chimp/ bonobo branch 6-7 million years ago.

The grand unifiying sequel theory
Taking many of the points above and the old movies as a base:

There will be a three-sided conflict between Caesar and Will who want a peaceful coexistence between the apes and the humans, the US government that considers the apes as the source of the plague and Koba who wants to Kill All Humans. Koba kills Caesar during a police raid and convinces the other apes that he was killed by humans, taking over the gang and declaring war on mankind. Another battle ensues, where it is revealed that Koba was actually Caesar's murderer before he dies. Maurice then takes over as ruler of the apes and establishes both the Ape Shall Never Kill Ape rule and that apes and humans can't coexist, eventually becoming The Lawgiver and giving rise to the political dominance of orangutans in the next centuries.

The astronauts won't come back until the third movie.

The "5 years later" caption was add after production by someone who understand how long it takes to chimpanzees to mature.
It doesn't make sense otherwise since the story doesn't seem to progress as much as it should

1. Nobody seem to notice that Will father is a fully functional adult again and ask how it happened. 2. There are apparently no incidents with Jerkass neighbor despite the fact that after the first incidents it seem like he was planning to do something about the ape situation. 3. If Will and Caroline been dating for that long, how come she doesn't know where he works?

The only way all those thing would make sense is if only a few months were intended to pass.

A sequel would have an extreme downer ending.
Looking at how ROTPOTA leaves the various characters this is only a natural conclusion for the next movie, or spread out with several. Will and Caroline, with most of humanity, will be dead due to the virus. Caesar, like his cinematic basis, has a "live and let live" outlook on ape/human relations. This implies that he will also be overthrown and/or murdered at the end and replaced by a more anti-human ape, possibly Koba. The effects of the plague and the growth of ape society will lead to the world where apes rule and humans are no more than slaves/scientific research subjects that the astronauts will return to.

Children of Men is a sequel to the movie.
The virus mutates so it is not so virulent, it merely removes reproductive ability. While the human race slowly exits, the apes experience a great birth rate.
 * So, the "II American Civil War" mentioned in CoM was between humans and apes?
 * Possibly, but more likely the apes were just biding their time as the humans killed each other off and died off.