Ultimate Spider-Man/WMG

Ultimate Clone saga and
The ultimate universe will follow the original concept that was rejected in the mainstream.

Flash Thompson will join the Friends of Humanity.
His hatred of mutants gotten to the point that he'll no longer go to a school that'll allow mutants. He'll also have his new friends beat up "mutant lover" Kenny as an excuse since Flash never liked him to begin with.
 * Flash's treatment of Kitty after Ultimatum is like the high school version of Wrath's treatment of Wolverine : she won't get hurt, so it's okay to throw things at her.

Kingpin is still alive.
Can't believe it took me so long to realize this. He was killed by Mysterio of all people. The one Spidey villain whose entire gimmick is creating illusions and making use of Mind Screw. Mysterio could be an employee of Fisk who staged his murder so that Fisk can rule the underworld without free of suspicion. After all, who would suspect a dead man?
 * Possible. Then again, Anyone Can Die.
 * No way. Kingpin is a Man of Wealth and Taste, he doesn't want to live a life underground directing gangsters from the shadows, he wants respect, acknowledgement and comfort.

Norman and Harry will come back from the dead.
The Ultimate goblins are FAR more powerful than the classic goblins. Just look at Norman's escape from the Triskelion in the 'War of the Goblins' arc, he practically evolved himself to the point where no prison could hold him and by the end of the arc he and Harry were literally superpowered, able to leap hundreds of meters in a single bound, shrug off automatic weapons fire like a gentle rain and rend metal with their bare hands, while the 616 characters' powers don't go beyond moderate Super Strength and a Healing Factor. And even that was enough for 616 Norman to come back from a friggin' metal spike through the heart, even after he was confirmed dead, imagine what the ultimate ones can survive. Especially as Norman's death was neither explicitly shown nor openly confirmed. Given that both characters were criminally underused (especially considering that Norman is classically Peter's nemesis) it'd be shameful for them not to be brought back.
 * It seems to have been.

"The Death of Spider-Man" will be metaphorical.
Peter won't die, but we'll see a shift in his character that could be described as a metaphorical death for the character, or he'll assume a new identity like the Scarlet Spider.

The game version is What If? story.
It tells about:
 * Eddie Brock taking control of the venom suit absorbing the remnants of it from Peter.
 * Silver Sable discovering Peter is Spider-Man.
 * No, the game was originally intended to take place in continuity, but it took so long to bring it in, that it wound up being a pragmatic adaptation that falls under What Could Have Been.


 * Remember that magical artifact that could grant any wish from #153-154? Yeah, that's totally not going to have any significance in the future.

MJ will turn out to have someone to remember Peter by

 * It would be completely unfair to have had Peter die a virgin. Plus, with 616 Peter dating Carlie, we gotta have one universe with an actual May "Mayday" Parker.
 * Erm... what exactly is so wrong with Peter dying a virgin? You do realize that it's people like you who go "it's so unfair for Peter to die a virgin" that make the rest of us men look like sex obsessed horndogs.

Eddie Brock will be the new Spider Man

 * Look at the new suit. Mainly black, not unlike the Venom symbiote, but also with trace amounts of red trim, hinting at the presence of the absorbed Carnage symbiote? Maybe after learning what happened to Peter, Eddie will realise he was wrong about him and be inspired to become a hero himself.

The new Spider-Man will be Scorpion

 * He was the only clone unaccounted for.
 * The Fantastic Four had him, and he was presumably handed over to SHIELD.
 * He is in Shield custody but apparently still alive. Therefore...

Scorpion will eventually be released and compete with Miles Morales for the title of Spider-Man.

 * He was probably being rehabilitated by SHIELD after the FF turned him in. He will be the "official" Spider-Man of the Ultimates, but Miles will still probably be the Spider-man of New York.

Ultimate Peter was killed because of One More Day

 * Think about it, what was the whole point of OMD? To return Peter to his carefree days as a bachelor; But the big flaw with this reasoning was that Ultimate Peter already filled that void, plus he was still in a relationship with Mary Jane. With Amazing Spider-Man still not back selling the numbers it was before Joe Quesada's pet storyline, does it really seem out of the realm of possibility that Quesada ordered the character's death in the Ultimate universe & the cancellation of Amazing Spider-Girl (Where Peter & MJ's marriage remained intact) in order to force people to buy ASM by having it be the only book with a bachelor Spidey?
 * Actually, Joe Q loved the Spider-Girl book and actually gave it alot of chances to get sales up.

A theory on the He will have some sort of connection to Peter Parker.

 * A lot of people know that  What a lot of people don't know is that the series is continuing, with   The first issue of Ultimate Comics: Spider-Man Volume Two due to come out this September. I believe that it will be far more dramatic if this   will have some sort of connection to Peter besides
 * Jossed. The new Spider-man has little connection other than having the same powers. The idea is that Pete on his own could inspire others to use their own gifts responsibly. And he did--the new Spider-man only came to be because he was inspired by the original.

A possible idea on the

 * For those who have read some of the previews for the new line of Ultimate Comics you will know that  When you combine this with the fact that   and that   there is reason to suspect that the new Spider-Man might be  . It would also be a rather easy fit too because
 * Jossed.

How much do you want a bet that the new Spider-man is only a temporary replacement before Peter Parker comes back from the dead?

 * I give it a year
 * I guess i am the only one who guesses Peter wont be back at all.
 * You are not. The Ultimate universe generally avoid bringing people back from the dead. The Ultimate universe is more realistic after all. After all, the first Black Widow died and has stayed dead and she was replaced by an asian character. The Ultimate universe if for them to do things you couldn't do in the 616 universe, such as killing Peter Parker(Who's still alive in the 616 verse anyway).
 * Depends on how well the new guy sells- alternate universe or not, Ultimate Spider-Man was a very popular book (for a time, it actually outsold Amazing). If the replacement brings a sudden dip in sales and can't bring them up again, Marvel will either cancel the title or just go, "Fuck realism" and resurrect Peter. Besides, being "More realistic" certainly didn't keep Norman from crawling out of the grave.
 * Or they could end up doing a book about Ultimate Spider-Woman if this were to happen.
 * There's still that Scorpion clone running around too.

MJ will hook up with Spider-Woman!
MJ will find out Spider-Woman is Peter's clone and has his memories(Up to a point). In a case of If Its You Its OK she'll fall for Jessica, since she's Peter, but in a Woman's body. Jessica has also mentioned she does have feelings for MJ, so it could work.

Someone will make a deal with Mephisto to bring Peter back to life
You remember how OMD came about? It was because Peter made a Deal With the Devil to save Aunt May. The Ultimates might reinterpret the OMD incident and have someone else will make the deal.

Everybody is going to show up for a What the Hell, Hero? moment
Pretty much everybody in the superhero community loved Peter Parker. Jessica's already turned up, but she won't be the last.
 * Except for Fury, he was pretty mellow with Miles.

Kraven the Hunter will be voiced by John Dimaggio
And it will be awesome

Jennifer Hale will reprise her role as Silver Sable in the new Ultimate Spider-Man cartoon
A role she previously had in the Ultimate Spider-Man game( And several other games ). The person who did the music for the Ultimate Spider-Man game is returning to do the score for the animated series, so maybe.
 * Welp, she's working on Generator Rex right now, so she's certainly in a position to do voice-work. Fingers Crossed?

When Miles is really down on his luck, everyone will learn about his motivation for taking up the role of Spider-Man.
And, finally understanding how things looked from Miles's perspective, they'll start to feel somewhat sorry for the kid. They won't regret pulling What the Hell, Hero? Him, but they'll start to sympathize with him at least. The fact that Miles' dad is a mutant-hater and probably won't be too thrilled about his son's powers may or may not play a role in all of this.
 * Nick Fury is pretty understanding of him A.) being thirteen years old, B.) having the balls to do good with his powers, and C.) being not necessarily a bad substitute.

There will be an episode where Norman manages to abduct Spidey.
And his friends will come to the rescue.

The New Venom will be...
(well, a small portion of the distilled aggression survived, so the new venom will be...)
 * Harry.
 * Norman.
 * Dr. Octopus, as the Poisonous Octopus
 * Flash Thompson.

Curt Conners will lose an arm
And become the Lizard. It will be when the series gets darker and edgier

Harry Osborn will become the Green Goblin
Possibly thanks to the symbiote corrupting his brain. Again, if and when the series becomes darker and edgier.

There will be a story arc analogous with the Identity Crisis storyline.
Spider-Man gets framed for something and has to go deep undercover to clear his name, keeping his teammates in the dark; He creates four new identities and interacts with them while in costume.

Each of the identities would be analogous or contrasting with his teammates:
 * Prodigy for Power-Man: Strength and Invulnerability.
 * Hornet for Nova: Flight and Ranged Attacks.
 * Dusk for Iron Fist
 * Ricochet for White Tiger

Miles Morales will make an appearance.
If only for the sake of continuity, and likely nothing more than a cameo, late in the series.

This show is pet for Jeph Loeb, Disney and Joe Quesada
This show is one large pet for Jeph Loeb, Disney, and to an extent for Joe Quesada. Hated by fans? Absolutely, to point that Jeph Loeb's Facebook page got so many complaints about this show that his page was removed and that's not everything. There is even a petition to cancel this show, and that happened when only 8 episodes were aired and throught various forums people say that Ultimate Spider-man sucks or that it is the worst superhero cartoon. Loved by writers, executives and being shilled? While going by this article it seems that many people who work on it hate it, but Jeph Loeb and other Marvel big guys believe that show is doing great. Jeph Loeb and Quesada always said that this show has "Marvel's DNA", that it is a next step for Marvel Animation and they believe that this show is the future of Marvel Animation and believe that this show is what Marvel Animation should be. Also after the show earned an undeniably large hatedom, Disney XD decided to run some new Ultimate Spidey episodes without new Earth's Mightiest Heroes adventures after them, to see if they deserve the credit for Marvel Universe's ratings. It gives an impresion that Disney seems to care more about Spidey than Avengers. And there's also the rumor that Avengers Earths Mightiest Heroes is going to be cancelled for new show that will take place in same universe as Ultimate Spidey.
 * Is this a rant or a guess? And on a side note, perhaps they're trying to recreate the 80's with long running, comedy based shows that could last forever if kept going long enough thanks to merchandising.

This show is Marvel's way to Follow the Leader
Namely, it's following the leaders that are Phineas and Ferb, Spongebob SquarePants and My Little Pony Friendship Is Magic. Think about it: Bright shows with morality tales for the watchers, a reinterpretation of a classic formula (well for MLP at least), hidden story arcs even within the mostly stand alone episodes (the venom ministory springs to mind), Image Spot moments. As all these shows have become successful, lucrative and beloved, this is Marvel's attempt to create a superhero show guaranteed to last FOREVER, be their Cash Cow Franchise, allow them to explore both the more famous and more obscure parts of the marvel universe (I mean, in what other show would you have your warm-up villain be someone as obscure as The Trapster), and overall, create a new animated universe far more permanent than those X-men shows, their older spiderman shows and the like ever were. At least, that's what I think.
 * To be fair Phineas and Ferb and My Little Pony Friendship Is Magic are rather different due to being more calm and more thought provoking references (The philosopher cards in the P&F movie and the greek myths/science/nature Genius Bonus while Spongebob is more manic but YMMV

Hydra will have its own team of teenage villains
Red Skull or Baron Von Strucker will assemble a team of HYDRA agents to kill the SHIELD team.
 * The Big Bad - Red Skull's daughter, Sin.
 * The Dragon - Crossbones, with Sin as his girlfriend.
 * The Evil Genius - The Mad Thinker, the ultimate version more likely.
 * The Brute - Rhino, again the ultimate version.
 * Dark Chick - Spider Woman. Jessica Drew was a HYDRA agent who tried to kill Fury and could be the most likely to do a Heel Face Turn.
 * Their "Agent Coulson" could be Taskmaster with him being their mentor in a rival school or being on the school board of the main high school.

The spider bite gave Peter both cancer and an increased healing factor
Subsequently, Spider-Man lost his sanity from having cells die and re-grow in succession.