ZOMG!/YMMV


 * Demonic Spiders: Kokeshi dolls. Woe betide if they gang up on you... and they always do.
 * They're non-aggressive. If you'd rather not have to deal with half a screen's worth of them, don't bug them.
 * The pink giftboxes!!! When they fly... you die.
 * Fluffs. In the first two areas, they're harmless little things, but from Zen Gardens on, if you piss off a fluff you usually start regretting it pretty quick.
 * Bladed Vases and Tiny Witch Doctors. The former because it's really easy to find yourself with four or five of them ganging up on you (but a Fire Rain attack charged with full rage will wipe most of them out); and the latter because it keeps paralyzing you so, so many times each time you try to attack. And if you don't have ANY kind of ranged attack...
 * Freud Was Right: There is a crystal formation in the Sealab Compound that has been compared to a phallus. Not to mention, which is now subject to That's What She Said jokes in-universe.
 * Good Bad Bugs: You used to be able to buff NPCs. Cue people spamming speed buffs on the Pizza Delivery Guy just to see how fast they could make him run.
 * Nightmare Fuel: The flying gift boxes at Bass'ken Lake. Little cute pink boxes with tiny wings, but get their attention and suddenly they have More Teeth Than the Osmond Family, giggle dementedly, and cry "FILL THE BOX!" over and over again. And they hunt in packs.
 * Memetic Badass: Landshark. In-game he's been pretty heavily nerfed.
 * Memetic Molester: Marshall.
 * Memetic Mutation: GIFTRAPE!
 * "DEFIB PLZ DEFIB PLZ DEFIB PLZ" and its cousin "HELP HELP HELP".
 * "CREW ME PLZ"
 * This pic about sums it up.
 * Nightmare Fuel: When Gaia first released videos of the Kokeshi Doll animations, many a viewer nearly wet their pants.
 * The Flying Pink Gift Boxes. A flock of giant, winged, slobbering gift boxes with huge teeth flying after you screaming "FILL THE BOX!"
 * That One Boss: There have been dozens of threads made to complain about Kat's Kokeshi Doll. Even after it was nerfed.
 * Tier-Induced Scrappy: Iron Will was considered weak until the Willpower mechanic was properly implemented. Adrenaline and Knife Sharpen were disregarded as weak after they became debuffs. And the number-crunchers on the forums all despise Diagnose as a heal for its low efficiency and high aggro, though other players like it for its ease of use.
 * Rescued from the Scrappy Heap: Debuffs turn out to be really handy against vampires and werewolves in Deadman's Shadow, so Knife and Adrenaline are now important for every DMS crew. Diagnose's aggro-drawing properties are likewise utilized by tanking builds to distract supernatural nasties for other players to defeat.