Mafia: The City of Lost Heaven/WMG

Ralph has autism spectrum disorder or Asperger's Syndrome.
It is established in the game that Ralph displays an immense aptitude for cars, but is looked down upon by Salieri and most others as a "complete idiot" or a "moron" when it comes to everything else, save for Tommy who appears to be more sympathetic towards him. Since people with Aspergers may display repetitive or a narrow set of interests, converse mostly about their favourite things and tend to be clumsy, it seems to line up with Ralph's focus on cars and social awkwardness. Though despite his awkward interactions with others, he is shown in the remake to have built up a pent-up sense of contempt towards those who bullied him especially Paulie whom he threatened to sabotage his car behind his back. And since awareness of autism spectrum disorders aren't as much in the 1930s as it is today, it's easy for Ralph to be dismissed and bullied upon due to his condition.

Sarah and her daughter will join or start an antimafia movement.
Given Tommy's brutal death in the hands of Vito and Joe, and since there is still the possibility of the Salieris going after Tommy's family as well, the now-widowed Sarah and her daughter may as well either join or start an antimafia advocacy group to further shield them from mob retaliation than just witness protection alone, similar to how Sonia Alfano became president of an association for the families of Mafia victims as his father was murdered by the Sicilian mob in 1993. (Alfano herself actually denounced 2K for the release of Mafia II and called for the game to be banned as it reminded her too much of what happened to her father; what she didn't realise was the game, while arguably violent and brutal, was written as a deconstruction and a cautionary tale rather than to glamorise crime.)