Cells at Work!

Cells at Work! is a manga that takes place in a human body. It's been compared to Osmosis Jones. That said, Cells at Work has much more accurate detail. It has an anime adaptation and spin-off mangas. The protagonists are a neutrophil (a type of white blood cell) and a red blood cell.


 * Darkest Hour: Hypovolemic Shock
 * Foreshadowing: The allergies that are suffered in the allergies arc are very low stakes. They are the kind that make someone feel sick and miserable, and are far from life threatening. Heck, even the microscopic single cell characters aren't in much danger. However the person that the body clearly took medicine to deal with it during the story. This reminds us that modern medicine is something that human bodies can receive these days, and also tells the audience that its use is fair game (at least in situations that would be noticed by people), which the author once again uses when the stakes are much higher and things look hopelessly grim.
 * Mood Whiplash: In the anime, things were not looking good at the end of part one of the "Hypovolemic Shock" plot. Then we get the usual cheerful end credits.