Pokémon Black and White/Tear Jerker

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 * theme. It even has some parts that sound like the Mother 3 Love Theme and A Letter From You, My Sweet from the same game. The entire scene it plays over- is pretty touching as well for a Pokémon game.
 * It could actually be happy, because he's off to finally see the world for himself and find his own purpose in life.
 * Likewise, gives a rather disturbing and heartbreaking vibe. It has an eerie, childish remix of his theme playing in the background. Whether it's more disturbing or heartbreaking is probably up to the player, but there's something very sad about . It really drives home how isolated he's been his whole life. When you combine this with the psychological Fridge Horror of
 * A sort of meta example, but Nintendo has said on record that Black and White were a "re-visioning" of the series. They wanted to capture the original feel of the very first games, as if you were starting all over again. And then you get songs like these where the wave of nostalgia just threatens to let the waterworks loose.
 * The first time that music plays, when Bianca's father appears at Nimbasa City to try and take her home... For Bianca fans, it's an especially depressing moment.
 * The girl asking you to ride the ferris wheel with her in Autumn, feeling depressed knowing that summer is over and all her friends are at school or on journeys. Once actually riding the wheel with her, she begins to stutter with sadness and asks to sit next to you until the wheel descends.
 * Likewise, there is a kindergartener in Winter who asks you to ride with her, and then after the ride talks about how her father just comes home late after work and sleeps, never spending time with her. A player can infer that her father was an alcoholic, just coming home after drinking all night and passing out. Hell, you don't even need the alcoholism angle to make this sad. This could simply be a girl with a dad that she loves dearly, but he's so focused on his job that he doesn't have the time or energy to give her once he's done. He's addicted to his job and chasing success - even if he might have started out with good intentions in the beginning. Given that Word of God states that culture in Unova is based roughly on American culture, the implications that are there are equally painful.
 * One of the people you ride the ferris wheel with is a sickly young man. It takes all of his willpower to get to the ride and back home.
 * Yamask.
 * How about Alder and
 * Another example from the Celestial Tower: One of the random trainers you can battle says she has a really strong Pokemon. Upon beating her, she remembers that she doesn't have one, at least not anymore. Considering that this is the Celestial Tower, it's not too hard to connect the dots.
 * Everything about N. From his past, to the ''), this character WILL make you cry by the the end.
 * YMMV, but
 * The music only ups the tear-jerker factor
 * Another example from the Celestial Tower: One of the random trainers you can battle says she has a really strong Pokemon. Upon beating her, she remembers that she doesn't have one, at least not anymore. Considering that this is the Celestial Tower, it's not too hard to connect the dots.
 * Everything about N. From his past, to the ''), this character WILL make you cry by the the end.
 * YMMV, but
 * The music only ups the tear-jerker factor