Cheeky Mouth

In larger budget productions, there's sometimes an entire animator just for the lips of characters, due to the squash-and-stretch aspect of the face deforming on a cartoon character. In cheaper animation, artists will use tricks to minimize the amount of distortion to the face, so you just animate a mouth moving on a static face.

The problem occurs when you see characters in profile (that is, when they're facing to the side of the camera, so you see half of their face), since the face should be animated. Lower budget cartoon (especially anime) artists tend to actually show the (already small) mouth from a 3/4ths viewpoint, even if the face and lips are still in profile. Since small noses often require drawing them to a point, this creates a weird flounder/Picasso effect or 'snout' as the character's mouth is no longer centered but completely on the side of the face.

This is understandable for animation, as it's a budget saver and makes production go faster. This trope becomes artifactual in other media, specifically comics. Despite the fact this trick is really necessary only in a moving picture medium, a fair number of amateur artists do this, either due to inexperience, laziness, or adherence to the visual trope. This effect can be averted by simply avoiding profile altogether and doing 3/4 points of view instead. When it comes to time savers, some artists will cite preference for this kind of drawing with other short cuts such as the Pacman mouth.

Compare Cheated Angle.

Anime and Manga

 * Pani Poni Dash uses this, as illustrated on the page image.
 * An eyecatch for Azumanga Daioh features Sakaki drawn in this style.
 * Most of the series uses this, actually.
 * Happens a lot in the Fullmetal Alchemist manga, even though there isn't any need for lip flap. In this case, it makes the artwork more dynamic.
 * Particularly visible in Bleach at some points.
 * Used in both the anime and manga versions of Zatch Bell.
 * Tengen Toppa Gurren Lagann perpetrates this often, despite the reasonably high animation level. Or maybe they spent all their budget on the giant robots.
 * Kyouran Kazoku Nikki uses this (when they are visible at all) for almost the entire cast, except for the lion Teika, who just doesn't get that many spoken lines.
 * Done quite frequently in Yu-Gi-Oh!
 * A common occurrence in Pokémon.
 * Appears a couple times in both the Hellsing OVA and TV series.
 * And is done repeatedly to Slasher Smile mouths.
 * All over the place in Slayers.
 * Fairy Tail does it with female characters in comic situations. In more serious situation, the females suddenly get a normal mouth, and the guys never have it happening to them.

Comic Books

 * Cerebus the Aardvark does this by design. Cerebus always has one of those, even when his snout does not obscure the view. When viewed en face, he has two of those.
 * Archie Comics characters often seem to have their mouths shoved over to one side of their faces, even when they're facing the camera!

Newspaper Comics

 * Pointed out in a Dilbert anthology by author Scott Adams, who prefers the Cheeky Mouth look.
 * Self-mocked by Bill Amend in this FoxTrot strip. A slight variation, since his comic is not animated and is not usually in profile.
 * Curtis; check out, for instance, the Curtis strip in here.

Video Games

 * Sonic the Hedgehog is usually depicted with a side-mouth, along with much of his supporting cast such as Knuckles who is almost never seen any other way. However, most characters in Sonic Adventure and its sequel were modeled with their mouths dead-center in the front of their faces, which looked awkward enough that subsequent games made it a deliberate art design choice that Sonic's mouth should always be at the side.
 * This gets really noticeable with the "Night of The Werehog" animated short they did. Sonic walks past a mirror, mouth facing camera, but on the mirror, he looks as if he has no mouth at all.
 * Sonic Heroes and the Wii-version of Sonic Unleashed averted this by simply not drawing mouths on the character models, though the cutscenes still had them. But the Werehog had one.
 * Ty the Tasmanian Tiger has a cheek mouth on either side of his face. The effect is somewhat... odd.
 * Jingle the reindeer in Animal Crossing has his mouth texture permanently on one side of his face. When you talk to him, he will often ask you specifically to make sure to only look at his "good side."

Web Comics

 * Dominic Deegan consistently uses this every time a head is seen in profile view, except for when the character wears a mask or similar face-veiling headgear.
 * Megatokyo.
 * Misfile.
 * Referred to as "Flounderface Disorder" in this Lackadaisy Expressions Tutorial.
 * Taken Up to Eleven sometimes in Penny Arcade, where characters' mouths reach past the edge of the face when they shout (like, here for instance).
 * Concession.

Western Animation

 * Done on Total Drama Island.
 * Look closely and you'll notice The P Js does this. And it's done in Claymation.
 * Can appear when a cartoon character has a big nose or snout that would obscure the mouth needed for an expression. Example: some Tove Jansson's illustrations of The Moomins show it.
 * This seems to be a genetic trait of the female side of Angelica Pickles' family. Both her and her mom have their mouths drawn far off to the side inside their cheeks. Even when you're looking at her full profile, her mouth is always drawn inside one of her cheeks instead of being where it actually should be like every other character in the series.
 * Rigby from Regular Show.
 * Rigby is Cheated Angle personified. When his snout points up, his eyes move down to the bottom of his head.