Mismatched Eyes



Complete heterochromia iridis is a medical condition where an individual has different-colored eyes.

In fiction, this often indicates a character with special powers, perhaps a Shape Shifter or magical being of some sort: traditionally, people with different colored eyes were literally assumed to be a witch, or a (possibly evil) spirit. If so, they can't mask their distinctive eye in any form. Unlike red eyes, this may be merely a sign of a Trickster, or someone with hidden attributes.

Alternately, it may indicate a dual nature or origin. Given the prevalence of odd hair colors and albinism in animation, just being pale with red eyes isn't symbolic enough anymore. Sometimes this is the budget version of Half Human Hybrids, but in any case it's some easily remembered Fashionable Asymmetry that doesn't aggravate the artists much (unless they have trouble remembering which eye is which color).

In real life, there are exceptionally rare instances where each eye might have multiple colors, but this usually doesn't show up in fiction.

As said above, it exists in real life, but in fiction, it will often use an impossible color for at least one eye.

A subtrope of Technicolor Eyes, related to Good Eyes, Evil Eyes. If a villain has these, it's a Red Right Hand. If one of the eyes is Gold, your ass is grass.

Sometimes referred to as "boat lights", a reference to the red and green lights that mark port and starboard on boats and aircraft. Note that for proper boat lights the red eye would be the left eye. Souseiseki's eyes are proper boat lights, while Suiseiseki's are reverse boat lights.

Note the Real Life diseases of which heterochromia is often a symptom do not appear much in fiction. This trope is not to be confused with Fish Eyes.

Anime and Manga

 * In 11eyes, Kakeru has a blind right eye, covered by an an overly large eyepatch and a completely normal blue left eye.
 * Jio Freed from 666 Satan has one blue and one red eye, as well as half-and-half hair. This is mainly to symbolize the fact that he is a host to Demon 1i, Satan.
 * Tokidoki from Amatsuki has one brown eye and one red eye; the red one indicates that his vision was stolen from it by a nue.
 * Arios, the White-Haired Pretty Boy from Angelique (golden/green). Might or might not be another clue that something is not quite right about him...
 * Kanade from Asura Cryin normally has blue eyes, but when she uses her powers, one of them turns to green.
 * Nei in Avenger has heterochromia to indicate that
 * Sven from Black Cat has one eye (his left) that's orange and one eye (his right) that's green. It's rather surprising that the green eye (which is a normal color for a human to have) is the special foreseeing eye, whereas the unusual orange colored eye doesn't have any powers.
 * His mismatched eyes are also justified in a flashback—he lost an eye in a fight years ago, the green one is a transplant.
 * In Black Lagoon, Balalaika is occasionally shown with her right eye glowing yellow-ish.
 * Nenene and Toki from Code Breaker both have one blue and one brown eye. This almost gets Nenene killed when fire bender controller Oogami mistakes her for his despised teammate Toki
 * in Code Geass ends up as this after he is made into a cyborg, with one orange eye and the replacement one being green. Arguably, Geass users as well, as when the Power Incontinence hits, it's usually only in one eye at first, meaning one eye will be its normal color, and the other will have the Geass symbol permanently imprinted on the iris.
 * Almost-example: Spike's eyes on Cowboy Bebop are slightly different shades of brown. It's very hard, but possible, to notice this before he brings it up to Faye. The reason is that one is a cybernetic replacement for an eye he lost in a very symbolic and personal tragedy.
 * Spike's Mismatched Eyes serve something of a plot function as well. Besides reminding us what he's gone through prior to his bounty hunting career, that cybernetic eye might explain why he's such an excellent shot with a handgun, at least when he's standing still.
 * This feature was brought up rather explicitly in the climax of episode 20, "Pierrot le Fou", where it is revealed that.
 * Allen Walker from D.Gray-man has one gray eye and one red cursed eye. Note that his eye is only red when an Akuma is around, otherwise it is the same gray as the other.
 * A minor Contractor from Darker than Black has red and green eyes.
 * Luki and Noki from DOGS Bullets and Carnage have very weird eyes (gold with a black iris, black with a gold iris, with the actual which-eye-is-which swapped between twins). They're enfants terribles.
 * The Count from Gankutsuou. This symbolizes not only his moral ambiguity and inner conflicts, but also the fact that he is . The duality symbolism is also present in some representations of his crest, a stylized heart divided into two clear compartments with different colours to represent.
 * Vetti Svorza of Glass Fleet has one purple eye and one shiny gold one. It's one of the early indicators that he's a little unusual.
 * Urumi Kanzaki from Great Teacher Onizuka is heterochromatic and.
 * Allelujah Haptism from Mobile Suit Gundam 00 has a Gray Eyes and a gold one. His hair always obscures one of the two, cluing any viewers into whether it is he or his evil Split Personality Hallelujah that is currently in control.
 * Albireo from .hack//AI buster has one blue eye and one gold, which has to do with his name—a binary star, one of which is blue, the other gold. Kamui has the same eye color, in dedication to him. Both characters' eye colors in the real world however are unknown.
 * The Artificial Human onmyouji Abe no Yasuaki and his Expy Abe no Yasutsugu from the Harukanaru Toki no Naka de series both have the light-brown/green combination. Somebody must have a thing for this, since the trend dates back to Haruka's sister franchise Angelique (see above).
 * The fifth game in the series seems to be continuing the tradition with Amami (blue and purple). (It's a lot more obvious on Tohko Mizuno's illustration than on the CG image.)
 * Posaydal from Heavy Metal L-Gaim has one gold eye and one blue eye. Strangely, the counterpart character in The Five Star Stories doesn't. FSS's Mel Zoom, Creepy Child Psycho for Hire, does, however.
 * Kamichama Karin has Michiru, a brunette with one purple eye (his natural color) and one blue eye.
 * In Katekyo Hitman Reborn Rokudo Mukuro has a red right eye with kanji in it and a normal, blue left eye. His right eye changes the kanji to suit the number of which path's (six paths of hell) powers he is using at that moment.
 * Heterochromia becomes an important clue in one of the extremely difficult mysteries Kindaichi is forced to unravel.
 * Ciel Phantomhive from Black Butler has a normal blue eye and a purple eye that holds the mark of his contract with Sebastian.
 * Alois later gets these when he
 * Mika Ayanokoji from Kyoshiro to Towa no Sora, whose right iris is purple and the left, orange (though, the latter may be an implant). Her dual nature seems to be that she is simultaneously manipulative and scheming and dangerously passionate for Kaon.
 * Oskar von Reuentahl from Legend of Galactic Heroes has one blue and one brown eye, which is the bane of his life --
 * Rosario from Lupin III: The Columbus Files has different colored eyes for plot-relevant reasons.
 * Vivio, from Magical Girl Lyrical Nanoha StrikerS has heterochromia, to indicate
 * In Magical Girl Lyrical Nanoha ViVid (which as the name implies, stars Vivio as the main character), Einhart Stratos also has heterochromia.
 * Asuna from Mahou Sensei Negima has heterochromia. The exact significance is unknown, but it's especially notable for its absence in adaptations that don't get into her Backstory.
 * As noted above, the heterochromia is absent in Negima?! and the first OVA series and instead her eyes are rendered as being blue.
 * Naruto
 * If we're counting implants, then it would be appropriate to mention Kakashi Hatake's singular Sharingan eye, which he keeps hidden under his askew headband.
 * Zetsu from, although has two yellow irises, has different color sclera (the whites of the eyes) to go with his color coded Split Personality. It is white on his white side and black on his black side.
 * The eponymous Hell Hound of Nora; when in human guise, his right eye is red and his left is yellow.
 * Vincent from Pandora Hearts, who has one red eye and one gold/yellow eye.
 * The Count D from Pet Shop of Horrors has heterochromia, one eye being purple and the other, whom he hides under his hair, is golden. In the manga, it's explained that.
 * Ramses from Red River has one brown eye and one golden eye.
 * In Rosario + Vampire, we have something of a subversion with the villainous Kiria, who, while not sporting different colored eyes (at least, not to my knowledge. It's hard to tell in a black and white manga.) instead sports eyes with rectangular pupils. Normally this wouldn't qualify for this trope, except that one of Kiria's pupils is completely perpendicluar to the other.
 * In Rozen Maiden Suiseiseki has red and green eyes, and was originally nicknamed "Boatlights-chan" by fans before she became known as simply "Desu". Her twin sister Souseiseki, introduced later, has the same eye colors but reversed. Appropriately, they are foils for each other. Also the previous Trope Namer.
 * Saint Beast: Goh
 * One of the characters of Saki has this, and.
 * Big Bad God of War Homura from Saiyuki has one golden eye, and one blue one, as a result of his father being a human.
 * As does Hakkai when removing his power limiters. Proving to many fans that the Eye Scream in his past was real and one of his eyes is artificial as the real one turns into an Eyes of Gold eye.
 * The perpetually-bandaged Abiru Kobushi from Sayonara, Zetsubou-sensei has one brown and one blue eye, though we don't find out until a trip to a bath-house temporarily removes the eyepatch.
 * Mikuni from Shangri-La has one gold eye, and one blue eye.
 * Mayumi Thyme from SHUFFLE! has one blue eye and one purple one.
 * They were blue and red in VN.
 * The clone Rezo the Red Priest, Big Bad of Season 1 of Slayers has one blue eye and one yellow. Since he is blind, he has his eyes closed throughout most of the season. His magic clone thingy gets mismatched eyes after bonding with a vaguely defined 'demon-beast' that doesn't seem to actually fit into the hierarchy of evil in the world's mythology.
 * Copy Rezo was shown with mismatched eyes from the start, although when he first shows up, . In the original light novels that the anime was based on, Copy Rezo kept his eyes closed for a different reason altogether.
 * In Sukisho, whenever Yoru takes over Sora's body, one of his eyes turns gold while the other remains blue.
 * In the second novel of Suzumiya Haruhi, Haruhi gives Mikuru one colored contact to wear during their filmed home movie, because "different colored eyes give an air of mystery". Hey, if anyone knows her tropes, it's Haruhi.
 * Though anyone watching the first broadcast episode alone won't know why it was there for one shot only. Other than continuity issues Haruhi did it, it's a case of All There in the Manual Light Novels light novels and second season. To explain:.
 * Syaoran of Tsubasa Reservoir Chronicle has differently shaded eyes to signify how one is blind. This further symbolizes how
 * By the last chapter of the manga, it's possible (although not confirmed by a color image) that ... yeah, Tsubasa Reservoir Chronicle is complicated.
 * Big Bad (of at least one arc) Rido Kuran of Vampire Knight has one blue eye and one crimson eye, a trait that shows up in the people he possesses. This is the first clue to Rima Touya that something's not quite right about Shiki...
 * Tyke Bomb siblings Segiri and Suika in Weiss Kreuz: Gluhen each have one blue eye and one brown eye.
 * Lord Darcia of Wolf's Rain has one blue eye and one golden wolf's eye, to show that
 * Watanuki in ×××HOLiC loses his eyesight in one eye and eventually If you think this is coincidence that it resembles Tsubasa Reservoir Chronicle, Yuuko would like a word with you.
 * CLAMP loves this trope. In X 1999, Subaru has one green eye and one brown eye While not technically heterochromia, Seishirou has a blank white glass eye that produces the same air of mystery.
 * These characters are from Tokyo Babylon and there is a detailed reason as for why there are like this. Still count.
 * In Yami no Matsuei, gate keepers can be identified by their different colored eyes. Wakaba has an orange right eye and a brown left eye.
 * The Yu-Gi-Oh! villain Dartz has one golden eye (his natural eye color) and one that was turned pale blue by the whole Orichalcos incident. And, if false eyes count, let's not forget Maximillion Pegasus, who has one brown eye and one Millennium Eye.
 * Yu-Gi-Oh! GX: Yubel has one orange eye and one green eye. In Season 4, after Judai merges with Yubel, his normally brown eyes change to these when using his newly acquired Green Lantern Ring powers.
 * Yu-Gi-Oh ZEXAL has Kaito Tenjo, whose eyes are silver. When he duels however, his left eye turns crimson. His eye colors are reflected in the colorations of his "Numbers" cards, Number 10: White Knight Illuminator and Number 20: Gig-Anto Brili-Ant.
 * In the manga Enchanter by Izumi Kawachi, if you become an enchanter, one of your eyes changes, turning deep red with a pinpoint pupil. Oddly, long-time friends don't seem to notice the change.
 * Yakumo in Psychic Detective Yakumo has one normal brown eye and one red eye which he usually conceals with a colored contact lens. The red eye can see the spirits of the dead.
 * Sasha in Blassreiter's final episode had them.
 * In the Distant Finale of Gurren Lagann, Simon has developed one spiral-shaped eye similar to Lord Genome's, likely to convey that he has mastered Spiral Energy.
 * The smug womanizer former monk Julio Cesare from The Familiar of Zero.
 * In Rental Magica, Itsuki was in an incident that turned his right eye into something demonic looking. Before that, said eye was still an unnatural red.
 * In Another,
 * In Rental Magica, Itsuki was in an incident that turned his right eye into something demonic looking. Before that, said eye was still an unnatural red.
 * In Another,

Comic Books

 * Delirium of The Endless, from The Sandman. It's part of her overall chaotic look. This disappears when she pulls herself together to be serious. She hates doing this as it is hinted it actually causes her physical pain.
 * Both lampshaded and subverted, as one line specifically states she can't remember which eye is supposed to be green and which one blue with sparkles. If you watch carefully, they do reverse from time to time.
 * It's the green eye that's initially stated to have silver flecks. But she has trouble remembering which one the flecks go in as well.
 * At one point, after realizing she can't remember which eye the flecks are in, they aren't in her eyes for the rest of the story.
 * The new 3D Man of Marvel Comics acquires red and green eyes to replace Skrull-detecting shades during Secret Invasion.
 * In the Post-Zero Hour Continuity Reboot of Legion of Super-Heroes, Triad has one amber eye and one lilac one. Well, Triad-Neutral does: Triad-Purple and Triad-Orange have both eyes the same colour. (Purple's are lilac, Orange's are amber).
 * Nicodemus West in Doctor Strange: The Oath has one brown eye and one blue.

Fan Works

 * After her astral body's left eye is damaged/destroyed during the battle in Hell in chapter 5 of Eric Hallstrom's epic Ranma and Akane: A Love Story, Akane Tendo's actual left eye becomes solid black with swirling clouds of red and gold -- and sometimes flashes entirely metallic gold.

Film
"Wayne: Well, we'll go through these forms with a fine toothed comb, cross the "t"s and dot the... lower case "j"s."
 * Hiroyuki Morita's The Cat Returns—Both the Cat King and the Cat Prince have different colored eyes. The King takes it further by being crosseyed and crazy.
 * A nonhuman/humanlike appearance example: in Shane Acker's 9|Nine, the rims of 6's lense eyes are mismatched in color (one is more gold-ish, while the other is a gray color.) They're also different sizes.
 * Brother Aidan's cat Pangur Ban from The Secret of Kells, who has one blue eye and one green eye. The viewer may be interested to know that Aisling of The Fair Folk has green eyes, and human Brendan has blue.
 * Tank from Surf's Up, although it's very difficult to see (one blue, one brown).
 * In 28 Weeks Later, the mother and her son have heterochromia. When she becomes a vector for The Virus, it serves as a clue to her and her son's shared biological resistance to the virus, and an indicator of when they become exposed but remain unturned: one eye becomes bloodshot like a normal zombie's infected would, the other remains clear.
 * X2: X-Men United: Jason Stryker has differently-colored eyes, as does the illusory little girl he creates.
 * In X-Men: First Class Charles Xavier flirts with a (normal human) co-ed with one bright green eye and one blue eye. His jealous shape-shifting pal Raven AKA Mystique alters one of her "brown" eyes to golden yellow.
 * Supernova: A device meant to protect a single user from the stresses of light-speed travel is used by the two main characters despite warnings that such misuse can result in a merged Body Horror. (The others were busted.) Of course, that'd have been a major Downer Ending, so only some minor merging takes place, resulting in their exchanging an eye, each now having one blue and one brown.
 * Demolition Man gives the villain Simon Phoenix these. He also has non-natural hair, which fits in with the near comic-book nature of the film.
 * Max Zorin in A View to a Kill has this trait. He is played by Christopher Walken (see below) but it does serve as a Red Right Hand for the character.
 * In Wayne's World 2, Wayne and Garth need to organise their concert with a guy who has partial ocular albinism (one eye has no pigmentation, i.e. is white). Hilarity Ensues when they get distracted by this while pretending they barely notice and make several Freudian slips.


 * In The Unborn, the 2009 film, this trope is one of the indications that the protagonist is being haunted by the title unborn twin brother who is trying to possess her.
 * In Vicky Cristina Barcelona, Maria Elena (Penélope Cruz) tells her ex-husband that she doesn't trust his new girlfriend Christina because her eyes are of different colors. Then again, she's a tad crazy.
 * Brad Dourif's Wormtongue in The Lord of the Rings was meant to wear two pale blue contacts until the costumers discovered he looked creepier while wearing only one.
 * In Practical Magic, young Sally Owens cast a love spell for a man she thinks can't exist, by giving him very uncommon traits. One of these is that he'd have "one green eye, and one blue". Twenty years later, guess what color eyes Detective Hallet has?
 * The film Redwood Curtain, based on the play by Lanford Wilson. (See "theater" section below.)
 * In District 9
 * In Don't Look Back, the characters' appearances slowly change over the course of the movie. Characters who are midway through their transformations often have mismatched eyes.

Literature
"I glare at people through the cold blue one on the right side when I want to intimidate them; the brown one is for Glances Sincere and Honest."
 * Chip, the hero of Ira Levin's novel This Perfect Day, has one brown and one green eye. This causes him some embarrassment, since he lives in a world where genetic engineering and restrictions on who may reproduce have produced a world of near-identical people, all of whom have brown eyes. He eventually has the green eye replaced by a brown one, as part of a scheme to lull the Big Bad into thinking he was finally accepting his role in society.
 * Tyrion Lannister in A Song of Ice and Fire has, in addition to several other congenital defects, either heterochromia or partial aniridia, with one green eye and one black one.
 * Also, the minor character Shiera Seastar had one green and one blue eye, from the Dunk & Egg novels set in the same 'verse.
 * Discworld:
 * In Hogfather, the most distinguishing trait of the unhinged assassin Jonathan Teatime is his mismatched eyes: one has been replaced by a grey (black in The Film of the Book) glass eye, and the other is yellow-white with a pinpoint pupil.
 * Just so you realize how Ax Crazy Teatime really is, in a world where magic has costs and often goes haywire is the equivalent of nuclear weapons, he stuck a magical eyeball into his own head.
 * Nanny Ogg's cat, Greebo, also has mismatched eyes, one's a normal yellow cat's eye, and the other is pearly white and blind, presumably due to one of the many fights he's had with animals much bigger than him.
 * Star Wars Expanded Universe: Gaeriel Captison has mismatched eyes. They're constantly referred to in the book in which she's Luke's Love Interest, possibly indicating that Luke finds this an attractive feature. As does villainess Ysanne Isard, main antagonist of the X-Wing books. The right is blue, and the left is Red Eyes, Take Warning. They're often symbolically attached to the cold efficiency (her nickname is Iceheart) and fiery anger she's known for.
 * Gaeriel's daughter, Malizna, inherits the eye colors. Whether this has to do with genetics, The Force, or simple coolness isn't really clear.
 * The titular cat in Jon, Flora and the Odd-eyed Cat (pink and blue).
 * The Chosen One in the old fantasy magazine series The Ancestral Trail had one green and one grey eye. The green eye saw only good, the grey eye only evil.
 * Candy Quackenbush from Abarat.
 * In the Anne of Green Gables sequel Anne's House of Dreams, a pair of cousins have identical Mismatched Eyes, resulting in a longtime case of mistaken identity.
 * At the end of the fifth Artemis Fowl novel, the titular character gets one of his eyes switched with another character as a result of interdimensional travel, leaving both with one blue and one hazel eye.
 * Interestingly, two books prior in The Eternity Code, Artemis has this because of an iris cam.
 * In one Flashman novel, the fairly nasty Russian villain Nicholas Pavlovich Ignatiev has one blue eye and one eye which is half-blue and half-brown. Notably, Ignatiev is an actual historical figure, but his eye colour is not recorded in history, allowing the author to take a few liberties.
 * As an allusion to this, the villain of The Peshawar Lancers, one Count Ignatieff, has a blue eye and a brown eye.
 * In the book The Wild Road one of the characters, Mousebreath, is a male Tortoiseshell cat with an orange eye and a blue eye.
 * In Sarah Monette's Doctrine of Labyrinths, the wizard Felix Harrowgate has one blue eye and one gold eye. The blue(?) eye is a result of an injury, so mostly blind. The colors give him no specific powers, but it does freak people out.
 * The horribly inbred Martense clan from The Lurking Fear by H.P. Lovecraft all have this as a distinguishing mark. They have brown-and-blue eyes apparently..
 * In Kristin Cashore's Graceling, all "Gracelings" have this as a distinguishing characteristic. It becomes important to the plot when you find out that.
 * The Known Space novel Juggler of Worlds by Larry Niven and Edward M. Lerner reveals for the first time that Nessus, whom Niven created 41 years previously, has one red eye and one yellow eye. (Being a Pierson's Puppeteer, he has two heads with one eye each.)
 * All the clone "shatterlings" of Gentian Line in "House of Suns" by Alastair Reynolds have one green eye and the other a "wintery jackdaw blue", since they're all male and female "facets" of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeable
 * In the Matthew Reilly novel Scarecrow, Jonathon Killian has a green and a brown eye.
 * Morzan in the Inheritance Cycle. Though he doesn't appear in the books, Jeod describes him as having one blue eye and one black one, in a similar case to that of Tyrion Lannister mentioned above.
 * In The Master and Margarita, Bulgakov's novel, Woland's left eye is green, and right is black. Justified because he appears differently for different people, but always has abnormalities.
 * This aspect was omitted in the 2005 TV adaptation. Cue the outcry...
 * The evil sorceress Xayide has one red eye and one green in The Neverending Story.
 * Evil Diogenes Pendergast from the Agent Pendergast novels by Doug Preston and Lincoln Child, has one hazel eye and one pale blue eye. It's revealed late in the series that pigment loss in the blue eye is due to an injury which blinded him.
 * One Goosebumps book has the main character's best friend be a girl with Mismatched Eyes. This becomes a plot point when she mysteriously disappears and he starts seeing a dog with Mismatched Eyes around the neighborhood.
 * In the Roger Zelazny book This Immortal, protagonist narrator Conrad Nomikos has Mismatched Eyes, among other odd features. But then he  His unique appearance is an important plot point.

"Dunreath: My left eye is blue but the right one is brown. Didn't you really know that? Larry: You're kidding. Good God, they are different! Dunreath: (defensively) Well, it's not a disease!"
 * In the Keys to the Kingdom series, The Old One has one gold eye and one black one.
 * Giulia in Mika Waltari's The Wanderer has different-coloured eyes. She's an evil bitch, though, like most female characters written by Waltari.
 * In Nancy Springer's I am Morgan Le Fay, the titular character has one violet eye and one emerald green one, which marks Morgan as a fay. They're also described as very dark, so people actually have to look right into her eyes to see the difference.
 * In Julia Golding's Companions Quartet, several of the main characters have mismatched eyes, including Connie, the heroine (green and brown), her best friend Col (again, green and brown), and the villain Kullervo (green and gold)
 * In Jean Kerr's play King of Hearts:


 * In Quinn Fawcett's Mycroft Holmes novels, Paterson Erskine Guthrie, Mycroft's secretary and amanuensis, has mismatched eyes.
 * "Mirror twins" Eleda and Adele in The Truth-Teller's Tale by Sharon Shinn have these. Adele has a left blue eye and right green eye and Eleda has a left green eye and right blue eye.
 * In Jostein Gaarder's philosophical novel Maya, the character Laura has one brown eye and one green eye. The narrator thinks of this as somehow connected to her dual nature - one side of her seems to care for all living things and the planet as a whole, while the other side seems to care about everything in the world except human beings.
 * Hnick from Dmitri Yemets's book series Methodius Buslaev has one blue eye and one black eye according to book 3. Romasjusik is also described as having one golden eye and one orange eye. Both cases aren't natural, since the latter has artificial body, while former's body is stitched from at last two different corpses.

Live-Action TV

 * In Babylon 5's later seasons, G'Kar loses an eye ; when he receives the replacement, it is blue instead of red (due to supply shortages), giving him no end of consternation and a singularly unbalancing countenance. He's quite relieved when a second replacement, of the right color, arrives.
 * Chief Inspector Derek Conway in The Bill had this condition, mainly because the actor who played him did as well (and they didn't want to bother mucking about with contact lenses trying to make his eyes the same colour).
 * In one chapter of Goosebumps TV adaptation, there is a girl, best friend of the protagonist of that episode who has different coloured eyes, one blue and one in a darker greenish tone. That's because.
 * Lieutenant Aiden Ford of Stargate Atlantis has one eye turn completely black due to an accident during a Wraith attack on the city. This same accident also got him hopped up on and addicted to Wraith enzyme, causing him to go AWOL and hunt down the Wraith on his own.
 * The 1999 ITV miniseries adaptation of Oliver Twist gave Edward "Monks" Leeford one brown eye and one blue eye. Funnily enough he was played by Marc Warren, who went on to play Jonathan Teatime — another character with mismatched eyes — in the film adaptation of Terry Pratchett's Hogfather.
 * From CSI,
 * "Ian Moone", a recent villain on the series, has one blue and one brown eye. In this case, it's presumably done to make him recognizable to the audience, as he wears a skin-tight bodysuit and full-face mask.
 * Samurai Sentai Shinkenger, episode 43, features this and Red Eyes, Take Warning with Fuwa Juzo, the half-monster semi-villain. Can be seen at 6:24 here.
 * The Chief in Halfway Across the Galaxy and Turn Left has these, as well as a mechanical monacle.
 * Luther. Alice Morgan puts in a single colored contact lens when carrying out her Sickbed Slaying, presumably so the police officer she speaks face-to-face with will remember this unusual detail rather than her actual features.
 * Agent Kensi Blye on NCIS: Los Angeles has one dark brown eye and one hazel eye.

Music

 * Murdoc Niccals of the virtual band Gorillaz has two different colored eyes, one black and one red.
 * 2D temporarily had this during his coma year, as one eye was normal and the other fully black due to a fracture.
 * David Bowie has a permanently dilated pupil in his left eye, the result of being in a fight, that gives him the appearance of having two different colored eyes, making one look to be darker (sometimes dark blue, sometimes brown) than the other. For a clear view, look closely at the cover of 'Black Tie White noise'
 * Marilyn Manson sometimes wears non-matching contact lenses to look as if his eyes don't match.
 * Tim Mc'Ilrath, vocalist of Rise Against, has those too. One brown, and one blue.
 * The UTAU Yokune Ruko has one red eye and one blue eye.
 * Utatane Piko has one blue eye and one green eye.

Professional Wrestling

 * WWE wrestler Kane has one light-blue eye and one brown eye, with the pupils being slightly different sizes (an effect achieved by the wrestler wearing non-matching contacts, like Marilyn Manson). Early in his run, it was implied that the blue eye was actually damaged by the fire which had "scarred" him, and that he was blind in that eye. Note to the WWE brain-trust: even we wrestling fans realize that eye color does not work that way.
 * Actually, the original implication wasn't that the fire caused Kane's eye to become miscolored, but that it was a false eye altogether, implying that not only had Kane lost sight in that eye, he physically lost the eye as well. This was ignored as the years went on, and now the mismatched eyes aren't even commented on at all, but because it's such a well known feature of the character, it has remained despite no longer even seeming to matter in the character's admittedly screwed up history.

Radio

 * In the world of Marus, as depicted in Adventures in Odyssey's Passages tie-in episode, different-colored eyes are recognized as a sign of prophecy. Interworldly interloper Alice physically goes from having brown eyes to blue and green, then loses them again when her time as The Unseen One's messenger is up.

Tabletop Games

 * Shelyn, the Goddess of love and beauty in Pathfinder sometimes appears with one blue eye and one silver eye.
 * Valerie Rose from the Fantasy Strike games (Flash Duel, Puzzle Strike and Yomi) has one blue eye and one green eye, and is canonically stated to have heterochromia.
 * In Yu-Gi-Oh!, the Lady of Lament archetype is a small (four monsters) group of female Fiend-Type monsters (Alice, Lilith, Loris, and Malice), and all of them except Loris have this feature, one green eye and one red eye with a black sclera.

Theatre

 * The play Redwood Curtain is centered on a young Vietnamese girl who was adopted by an American family. She has "eyes like a husky dog" (one blue, one dark). When she meets a homeless Vietnam vet who has similar eyes, she starts wondering if he could be her biological father.

Video Games

 * In Quintessence: The Blighted Venom, Kardian (Alden) performs an operation on Lunair using Reivier's eye to cause her right eye to turn green whenever Shanti takes control, as a warning.
 * An updated artwork of Louis Cyphre from Shin Megami Tensei II shows that he has a red pupil on the right, and blue on the left to indicate that he's no he.
 * Yuna from Final Fantasy X has heterochromia to indicate that she's . She has a green eye and a blue one.
 * Marx from Kirby Super Star is frequently depicted in fan art as having one blue eye and one red eye, either matching or opposite the blue and red sides of his hat. However, in the official artwork and sprites, both of his eyes are Purple Eyes.
 * In Final Fantasy XIV, Mi'qote characters can be created with offcolored eyes.
 * The vampire sisters in Castlevania: Portrait Of Ruin have heterochromia to indicate they aren't full vampires yet.
 * Lady and Arkham from Devil May Cry 3 have heterochromia. It doesn't actually mean anything...
 * It also serves as a visual hint that.
 * Katina Tarask in Super Robot Wars Original Generation. As of yet, no significance has been attributed to her character, but the fact that she was the winning design of a fan-submission contest may be explanation enough.
 * Levi Tolar, on-again off-again Dragon, originally from Super Robot Wars Alpha, has one red and one golden eye, to match her mecha Judecca. Her eye color changes fairly regularly though, depending on game and
 * Bitores Mendez, the village chief from Resident Evil 4, sports one blue eye and one red. The red eye is a falsie, though.
 * In Fallout, Dogmeat has one blue eye and one brown.
 * Ballos from Cave Story has one eye stark white, one eye stark red, neither with any visible pupil. It's probably less about his biology and more about making him look even more otherworldly than he already is, though.
 * The Demon Crown has one eye set in it, that is the same color as his remaining red eye. Fanon suggests that he set one of his eyes in his crown.
 * The GUN Commander from Shadow the Hedgehog, during the game's events and during flashbacks.
 * Ranulf in the 9th/10th Fire Emblem games has one Blue and one Pink/Purple colored eye. Though this is, plotwise, insignificant, a bit of reading implied that this led to potential blindness in cats, which may explain why he got his ass handed to him by every significant bad guy (and one good guy) despite being implied to be one of the strongest among Cat laguz... i.e. he keeps losing because he can't see worth a damn.
 * That's deafness rather than blindness that is connected with heterochromia in cats. Actually, it has to do with the genes that give cats white or white spotted coats. That genetic set up also allows for heterochromia and increased risk of deafness. Might still be a factor, though I only remember him getting really trounced by The Black Knight. He pretty much owns everyone else.
 * I always assumed it was a nice touch by the artist due to the fact that heterochromia is common in real life cats.
 * Also from the Fire Emblem games is Idoun one of the enemies in the 6th game, who has a red eye and a green eye. (It might actually be blue, but with sprites it's a bit difficult to tell.)
 * Dr. Loboto from Psychonauts wears goggles that consist of one green lens and one red lens, to highlight how abnormal he is in a world of already-freaky-looking people.
 * Psychonauts is full of people with mismatched eyes. Bobby Zilch as another one, as well as Coach Oleander and Linda.
 * Honoka Kawai from Osu! Tatakae! Ouendan 2 has a green right eye and a gray left eye.
 * Michel from Pop'n music has a yellow right eye and blue left eye.
 * It's possible to create Orc and Goblin characters with Mismatched Eyes in Warhammer Fantasy Battle Online.
 * Yuber in Suikoden III has one red eye and one silver one. He's also not human.
 * Ragna the Bloodedge of BlazBlue has these to indicate that
 * Kogasa Tatara in Undefined Fantastic Object, as a humanoid version of a karakasa (a one-eyed one-legged demonic umbrella) has one red and one eye the same color as her hair and outfit, as an alternative to merely giving her one eye.It adds to her Moe factors, maybe.
 * The Iris twins from Rune Factory Frontier, just like Souseiseki and Suiseiseki, have opposite-color heterochromia.
 * Lee, an early boss from Sword of Mana, has one gold eye and one red one. It doesn't seem to be particularly indicative of anything, though.
 * In Modern Warfare 2, the Big Bad Vladimir Makarov has one green eye and one blue eye.
 * In the Soul Series, Zasalamel has one normal-colored eye and one golden eye, possibly as a result of his immortality curse.
 * The Wizard in Harvest Moon: Animal Parade has one gold eye and one green eye.
 * Atsuki from Lux-Pain has a gold eye (his right), and a black eye (his natural color). Justified, in that in the power of Lux Pain made his right eye gold.
 * Mass Effect 2's DLC has Zaeed Messani, who has one brown eye and one pale grey eye. The paler eye is implied to be a cybernetic replacement installed after he survived a shot to the face.
 * Dr Betruger from Doom 3 has one eye that is not only a different colour, but has no pupil. Creepy, eh?
 * Sting Chameleon, from the Mega Man X series, has an odd version of this. Being a robot, one of his eyes looks normal, but the other looks metallic and appears to have an irising lid. The irises, however, are the same color.
 * He has one normal eye and one chameleon eye.
 * In Deadly Premonition, is eventually revealed to have different-colored eyes, his left eye having been damaged in a childhood trauma.
 * In Ragnarok Online, the pope of Arunafeltz has opposite-color heterochromia. Apparently, this was one of the reasons she was chosen as pope. The other reasons was her hair and skin color.
 * The main character in Homura has these in order to symbolise his half-human half-angel blood.
 * of Mother 3 is commonly depicted with these, while they're nowhere to be seen ingame. It might be because
 * Resonance of Fate allows players to change the colors of the main characters' eyes individually, thus creating quite a few options for mismatched eyes.
 * Puyo Puyo has Sig, who has one red eye and one blue eye.
 * There's a few examples in Vampire: The Masquerade Bloodlines. The Voermen sisters have blue and green, Mister Ox has grey and amber, and the Malkavian and Nosferatu PCs have blue and brown.
 * In Tales of Graces, this is a sign that . It happens to Richard and later, and this carries into Tales of Graces F.
 * Vanessa of Luminous Arc has one grey/purple eye and one red one, but this doesn't seem to indicate anything beyond being just as loud and noticeable as the rest of her.
 * GLaDOS from Portal is almost always given Mismatched Eyes of various colours when she's drawn as a human, to reflect how her personality cores all have different eye colours.
 * Ironhead from Swim Ikachan has a right red eye and a blue left eye, although you couldn't tell the latter's colour in his cameo appearance in Cave Story, since it can only be seen when he's facing left.
 * Johnny Powell in The Darkness 2. They're both blue, but his left eye's abnormal.

Visual Novels

 * Mary's normally blue eye right turned to gold six months before the story started in Shikkoku no Sharnoth. The golden eye is somewhat magical and a macguffin throughout the story.

Web Comics

 * Mannick from Charby the Vampirate has a red right eye, and grey (blue in some comics) left eye. It doesn't appear to mean anything in particular.
 * Sifris from Pink Black has a blue eye and a pink eye. This is never really noted or explained, so it is possibly normal.
 * Topaz from Monsterful; she has a two shades of the actual gemstone her name refers to, her left eye is light yellow and her right one is sky blue.
 * Ashley Freyja of Cry Havoc has one blue eye and one green, and while never actually mismatched, the werewolves eyes fluctuate between their natural color and yellow when angry or excited. Psychers eyes glow blue when they are using their powers.
 * The Cyantian Chronicles: Syris has one yellow and one blue eye.
 * Abel from Dan and Mab's Furry Adventures has different-coloured eyes. Then again, as he can shapeshift, he may simply think it looks cool.
 * According to his backstory, it's natural. Although he probably does think it's cool...
 * Apparently heterochromia (as well as wings that are both feathered and bat-like) are traits of an old and reclusive clan, though they occasionally appear in members of other clans and it's usually considered a good omen when they do.
 * Most of the Val'Sullisin'rune family in Drowtales have mismatched eyes, a fact that is commonly known in the setting and referred to as "devil eyes" in the case of the Ill'haress Ash'waren. It is not clear that they have any sort of "dual nature".
 * In the case of Ash's daughter Faen, the dual personality Blue = Innocent / Purple = Mysterious or Badass fits.
 * Kade from Eerie Cuties has a yellow/gold left eye and a blue right eye. Of course, he is a Werecat...
 * The chimera boy Archie from Ellen's second life dreams in El Goonish Shive, although he hasn't been drawn in colour yet, appears to have heterochromia, given that one of his eyes is filled, and the other has a pupil and a gap between the pupil and the outline of the iris.
 * Vladic from Emergency Exit. This could be normal for his species for all we know...we've never seen both eyes of the only other Merf character.
 * Skye from Far Out There has one green eye and one purple one. In her case, the difference is quite practical: the purple one has x-ray vision.
 * Prism from Flaky Pastry has one violet eye and one cyan eye.
 * Homestuck: Sollux has one eye that's completely red and one that's completely blue, thus making him an example of both Mismatched Eyes and Monochromatic Eyes. However, this wasn't immediately obvious because he wears a pair of red-and-blue 3D glasses almost all the time. This duality is symbolic of his bipolar disorder.
 * It's also been stated that Lord English's eyes are not only mismatched, they also switch around rapidly through the different pool balls to suit his pool motif. During one author-insert Non Sequitur Scene, Andrew's wish dragon also sports these.
 * Vriska also has one normal eye and one eye with seven pupils arranged in a hexagon.
 * Aria, from In Wily's Defense and Fetch Quest: Saga of the Twelve Artifacts, has one purple and one red eye. It's more apparent in the latter work.
 * The title character of Kokiro has heterochromia and wings.
 * Sudoku (Jigsaw's sister) in Last Res0rt also has heterochromia, with no special explanation attached other than her father (Cypher) having green eyes and her mother (Meridian) having blue. She's the only one in the family with this trait though.
 * Maureen from A Modest Destiny.
 * Tsukiko from Order of the Stick has one dark blue eye and one light blue eye. This represents her status as a Mystic Theurge who can cast both divine and arcane spells. The magic that emanates from each of her hands is the same color as the eye on the opposite side, and when she casts Dominate Person, the victim gains her heterochromia as well. She's also from a country built on East Asian stereotypes, so it's possible that the trope's presence in anime was a factor in character design (and her otherwise East Asian coloring makes the mismatched blue eyes particularly striking).
 * Her slippers also match her eye color. Apparently she's just decided to go with it.
 * Real-life game designer Keith Baker also has heterochromia, and is drawn with such when he makes a guest appearance in the prequel novel Start of Darkness.
 * Slightly Damned recently featured a Jakkai with mismatched eyes  called "Mr. Moonshade".
 * Christian Weston Chandler in Sonichu, though it's not at all striking. It's a feature of most his Evil Twin (with inverted colors) and his Chris-Chan Sonichu form, too.
 * Anibelle from The Wotch has one red eye and one green eye. Easiest to see in this filler comic done by a guest artist, but can easily be seen normally, too.
 * Oddly enough, though, these clearly mismatched eyes weren't present in her appearances prior to that guest comic. Possible case of Ascended Fanon?
 * Wally in Zebra Girl. One reason for this may be pragmatic—it makes him much easier to tell from the other wolves when shifted.
 * Charlie of The Zombie Hunters, a Half-Human Hybrid Zombie. has one normal, pale blue right eye, while the left eye has a black sclera and a glowing white iris, like those of most other Zombies. He easily conceals it with a special contact lens.
 * Kimiko of Dresden Codak has one brown natural eye and one blue mechanical eye as of the "Dark Science" arc, though originally her natural eye color was blue and thus the synthetic one matched when it originally showed up. Sen Diaz retconned it so the synthetic one would stand out more.
 * Feral from Strays. His green eye is natural,the red one was caused by something else. Feral, being mute, can't tell us what.
 * Berri in Fiyora Nya has one red eye and one green eye. Though they apparently change colors due to her other souls.
 * In a variant, Lilith/  in Girl Genius has eyes that are mismatched in size, due to being a construct. She wears glasses that make them look like they're the same.
 * In Doomsday, My Dear the main character has one blue and one green eye
 * Chev from Papi Nyang has one blue/green and one yellow eye.
 * Continuum justifies this with a character with one blind, discolored eye, best seen here.
 * Patchwork and Lace features Sheol, who not only has different eye colours, but different-shaped eye slits.

Web Original

 * Chaz Villette from Shadow Unit has one brown eye and one greenish-hazel.
 * Achmed the Snake from the Rhapsody Chronicles has eyes that are not only mismatched in color, but also in size, shape, and quite probably, species. Also, a face that looks like scar tissue, apparently.
 * Longhorn (Moe Anthropomorphism of Windows Vista) of the OS-tans.
 * Simon from My Life in Blue.
 * Hawley Faust from Survival of the Fittest has this, though outside of Epileptic Trees which might be true (most arguing that they symbolize Adam's nature pre-game and post-game) it has no actual significance.
 * As does Dominica Shapiro, who was much more dual in nature (displaying both a thoroughly villainous and surprisingly heroic side).
 * In version four, Charlene Norris has one blue and one green eye, while Clio Gabriella has one green and one hazel. Dave Morrison in the same version has a minor form.
 * Evolution's Child from SCP Foundation. In addition, sclera of one of her eyes is black.
 * Techno-Devil of the Whateley Universe has one eye that's a solid red cybernetic implant. He's only fourteen. He's a mutant too, so his other eye doesn't look normal either. In his case, it signifies that he's the son of the notorious supervillain Dr. Diabolik, and darn proud of it.
 * Cigarettes the Cat, a creation by John Kricfalusi. Left eye red, right eye blue.
 * This verson of Hellsing: The Abridged Series uses it for a one-off gag.
 * In The Masked Girl, Griffin has one brown-red eye and one blue eye.
 * Several characters from Homestar Runner such as Marzipan (one of her eyes is larger than the other), Bubs (one blue eye and one black eye), the Poopsmith (one black eye and one white eye), and Hyperactive Strong Sad.
 * Neo from RWBY is an interesting case, in that she appears to have complete conscious control over her eye color, and chooses to have one brown eye and one pink eye most of the time. Her "default" eye color appears to be white.

Western Animation

 * Mr. Lee from A.T.O.M. spend most of the first season as blue-eyed... then suddenly he appears with different-colored eyes. No one (except viewers) seemed to notice.
 * The Batman's version of Tony Zucco (the guy that killed Dick Grayson's parents) actually has a blue right eye, and a brown left eye.
 * Gearhead from The Batman has the classic green/red combination.
 * Two-Face, particularly in Batman the Animated Series, where the white of one eye has been stained yellow.
 * The main character of Ann Downer's Spellkey Trilogy has one green eye and one blue (which is a sign of magical power in that world).
 * A few characters from Steven Spielberg-produced Warner Bros. cartoons have one pink eye and one bluish-green eye, namely Dizzy Devil from Tiny Toon Adventures and Pesto from Animaniacs.
 * Dao long Wong in Jackie Chan Adventures.
 * Coldstone in Gargoyles is a slight variation—since irises aren't drawn, he has one red and one white sclera.
 * Botanica in Beast Machines has one yellow and one cyan eye while in plant mode.
 * Cyborg from Teen Titans has one cybernetic red eye and one normal eye, which is dark blue.
 * Harry the tomcat from The Garfield Show has the red/green combination.
 * In Happy Tree Friends, Nutty has one black eye and one green lazy eye.
 * Fastidious on Yin Yang Yo! has one purple eye and one blue eye.
 * Max the cat from The Penguins of Madagascar has one green eye and one blue.
 * Not official, but some fan art depicts Odd of Code Lyoko with mismatched eyes (usually a purple one).
 * Ned from Doug has one black bead eye and one round white eye with a black iris.

Famous People

 * Alexander the Great had heterochromia; one eye was very light blue, the other very dark brown, according to Plutarch.
 * Celebrities with heterochromia include Dan Aykroyd, Jane Seymour, Mila Kunis, Kate Bosworth, Christopher Walken, and Lee Van Cleef (who wore coloured contacts).
 * MLB pitcher Max Scherzer (currently with the Detroit Tigers) has one blue eye and one brown eye.
 * Silent film star Colleen Moore had one blue eye and one brown eye, though with the film stock available at the time, it wasn't very noticeable.
 * Mixed Martial Artist Jens "Lil' Evil" Pulver has one blue eye and one green eye.
 * Simon Pegg has sectoral heterchromia, with one blue eye and one blue-and-brown eye.
 * As does Elizabeth Berkley, her eyes being green with a brown spot on the right eye.
 * Virginia Madsen as well, her eyes being green with a brown spot on the left eye.
 * Too Big To Fail author Andrew Ross Sorkin has one normal hazel eye and one golden-brown cat-like eye (which looks really unnerving on a big HD screen).
 * Catherine Tate has central heterochromia as seen in "Turn Left".
 * David Bowie was often mistaken as having this. In actuallity, one eye was just permanently dilated, after he was punched in the face in a schoolyard fight.
 * Gracie Allen had different colored irises. When TV shifted to color, she retired (leaving George Burns as a solo act); she felt that it was too distracting/embarrassing to work in color.

Other Cases

 * This is actually a very common condition in real life. One can be born with it, or one iris may change color as a result of trauma to the eye. Though in the former case, it's more common for the "odd" iris to be only partially a different color.
 * Heterochromia is not particularly rare in domestic cats.
 * Heterochromia of both the one blue eye/one brown eye type and of the single eye with two colors type is actually very common in dogs with the merle color gene. (The two-eyed variety is also reasonably common in non-merles which have the blue-eyed gene, most notably Siberian Huskies and Border Collies.) Most famously, Mike the Dog, a Scottish border collie who stared in the film Down And Out In Beverly Hills, was well known for having one blue eye and one brown eye.
 * Or this puppy.
 * Horses are also sometimes possessed of one blue eye and one brown one. This is known as "glass eye" in the horse world and is most often seen with Paint and Appaloosa horses. The trait is also not uncommon among mustangs.
 * One blue eye and one brown eye is a frequent (and for many, defining) characteristic of Catahoula Leopard Dogs. Their ancestry is something of a mixed bag.
 * Same for Turkish Van cats.
 * "Odd-eyed" is the term used for this condition by many animal breeders.
 * This is also called "Bi-eyed" for Siberian Huskies, which have been known to have one blue eye and one brown eye.
 * Artificial heterochromia can result from certain cancer treatments, though this effect is usually temporary.
 * It can also result from an overly scarred cornea, causing the light to refract differently in the affected eye. If there is only one part of the eye that is scarred, that part is affected. If the whole cornea is scarred, the whole iris is a different color.
 * Animals with chimerism often have differently colored eyes.
 * Twins tend to be born with heterochromia.
 * An episode of "Medical incredible" had an episode that included this. While one could not tell by looking at the boy, if you looked in photographs, he had Mismatched Eyes. His mother thought this was very strange because it kept showing up in every single photograph, and only in photographs. Everyone else thought it was just a trick of the light or a camera flaw, but she knew something was up, so she finally insisted that doctors check his eye in case there was something wrong. Turns out, this was because of a rare eye cancer. You can rest easily - because they caught it early, they could cure it, and the boy is alive.
 * Using colored contacts to fake this has popped up as a short lived fad every now and then since the creation of color contacts. One of the few times it maintained any relatively extended popularity was among K-Pop artists.