US and Canadian Comics

Since the medium of comics arguably originated in the USA, it should come as no surprise that a whole lot of comics are American. Also included here are Canadian comics, as they are for the most part pretty similar to their southern counterparts due to the large amount of intermingling between the two cultures, businesses and talents, and often see distribution in both regions regardless of origin.

Companies prolific enough to have their own pages:
 * DC Comics
 * Dark Horse Comics
 * Image Comics
 * Marvel Comics

Aardvark-Vanaheim

 * Cerebus
 * Flaming Carrot
 * Ms. Tree
 * Normalman

Abrams ComicArts

 * Empire State

ACC Studios

 * Liberality for All

Ait / Planet Lar

 * Demo
 * The Couriers

Antarctic Press

 * Bad Kids Go to Hell
 * Chip
 * Gold Digger
 * The Littlest Zombie
 * Ninja High School
 * I Hunt Monsters
 * Twi Lit

Arcana Studio

 * One Hundred Girls
 * All Fall Down

Archaia

 * Artesia
 * Mouse Guard

Archie Comics

 * Katy Keene
 * Life With Archie the Married Life
 * Mega Man
 * Sabrina the Teenage Witch
 * Sonic the Hedgehog
 * Sonic X
 * Teenage Mutant Ninja Turtles Adventures

Aspen MLT

 * Fathom
 * Lady Mechanika

Avatar Press

 * Anna Mercury
 * Apparat Singles Group
 * Black Gas
 * Black Summer
 * Crossed
 * Doktor Sleepless
 * No Hero
 * Gravel
 * Supergod

Black Bull

 * Just a Pilgrim

Bongo Comics

 * The Simpsons
 * Futurama

Boom Studios

 * Adventure Time
 * Fall of Cthulhu
 * Hero Squared
 * Irredeemable
 * Jennifer Blood
 * The Muppet Show Comic Book
 * The Unknown

Broadsword Comics

 * Tarot Witch of the Black Rose
 * School Bites (Now a webcomic)

Broadway Books

 * Cartoon History of the Universe

Caliber

 * The Crow
 * Kabuki

Charlton

 * E-Man
 * The Question

Comico

 * Justice Machine
 * The Maze Agency
 * The Elementals

Comics Interview

 * Southern Knights

Continuity Comics

 * Bucky O Hare and The Toad Wars

Cross Gen

 * El Cazador
 * Meridian
 * Route 666
 * Ruse
 * Scion

Dell Comics

 * Neutro

Department Of the Army

 * PS Magazine

Devil's Due

 * G.I. Joe
 * Hack Slash

Disney

 * Abadazad
 * Donald Duck
 * Dragonlords
 * Jellaby
 * The Legend of the Chaos God
 * The Life and Times of Scrooge McDuck
 * The Incredibles
 * Wizards of Mickey

Dork Storm Press

 * Dork Tower

Dragon

 * Wormy

Dynamite

 * The Boys
 * The Green Hornet
 * The Last Phantom
 * Project Superpowers
 * Red Sonja
 * Vampirella
 * Zorro

EC Comics

 * Mad Magazine

Eclipse Comics

 * Adolescent Radioactive Black Belt Hamsters
 * Destroyer Duck
 * Fusion
 * Ms. Tree
 * Zot

Eros Comix

 * Ironwood

Event Comics

 * Painkiller Jane

Evil Twin Comics

 * Action Philosophers

Fantagraphics

 * Bitchy Bitch
 * Bitchy Butch
 * Black Hole
 * Castle Waiting
 * Eightball
 * Art School Confidential
 * Ghost World
 * Like a Velvet Glove Cast In Iron
 * Frank
 * Love and Rockets
 * Peculia
 * Small Favors

First Comics

 * The Badger
 * E-Man
 * Jon Sable Freelance
 * Nexus
 * Starslayer

First Second

 * Anyas Ghost

Fishwrap

 * Fish Police
 * Sam and Max Freelance Police

Gold Key

 * Jet Dream
 * Magnus Robot Fighter 4000 A.D.
 * Mighty Samson
 * Turok

Hannagram

 * Once Upon a Super Hero

Harper Perennial

 * Understanding Comics

Harper Teen

 * Miki Falls

Harvey Comics

 * Baby Huey
 * Casper the Friendly Ghost
 * Richie Rich
 * Little Audrey
 * Little Dot
 * Little Lotta

Heroic Publications

 * Flare

IDW

 * Fallen Angel
 * G.I. Joe
 * Kill Shakespeare
 * The Life and Times of Savior 28
 * Life Sucks
 * Locke and Key
 * Love and Capes
 * The Maze Agency
 * Teenage Mutant Ninja Turtles (IDW)
 * Transformers Generation 1
 * The Transformers IDW
 * Transformers: All Hail Megatron
 * Transformers Last Stand of the Wreckers
 * Transformers Robots in Disguise
 * Transformers More Than Meets the Eye
 * Wynonna Earp

Innovation

 * Justice Machine
 * The Maze Agency

Kenzer

 * Knights of the Dinner Table

King Features

 * Flash Gordon
 * Popeye

LEGO

 * Bionicle

Mariner Books

 * Fun Home

Minx

 * Water Baby

Mirage Publishing

 * Gizmo
 * Teenage Mutant Ninja Turtles (Original Continuity)

Mystic Studios Productions

 * Here Wolf
 * Horndog
 * Soft Desire
 * Tales of the Unrefined

National Hockey League

 * The Guardian Project

NEC

 * Johnny Turbo
 * The Tick

Nedor Comics

 * Jill Trent Science Sleuth

Nuage Editions

 * Angloman

Octopus

 * The Interman

Oni Press

 * The Adventures of Barry Ween
 * Blue Monday
 * Courtney Crumrin and The Night Things
 * The Good Neighbors
 * Jingle Belle
 * Local
 * Lost At Sea
 * Polly and The Pirates
 * Queen and Country
 * Scott Pilgrim
 * Scooter Girl
 * Stumptown
 * The View Askewniverse
 * Wet Moon
 * Whiteout

Pantheon Books

 * Asterios Polyp
 * Jimmy Corrigan the Smartest Kid On Earth
 * Maus

Paws

 * Garfield His 9 Lives

Platinum Studios

 * Cowboys and Aliens

Radical Comics

 * Incarnate

Red 5

 * Atomic Robo

Rip-Off Press

 * The Fabulous Furry Freak Brothers

Roaring Book Press

 * American Born Chinese

Sega

 * Sonic the Hedgehog Promo Comic

Scholastic

 * Amulet
 * Bad Island
 * Ghostopolis

Shanda Fantasy Arts

 * Extinctioners

Simon & Schuster

 * Amelia Rules

Slave Labor Graphics

 * Dead Eyes Open
 * Fun With Milk and Cheese
 * Hsu and Chan
 * I Feel Sick
 * Johnny the Homicidal Maniac
 * Lenore the Cute Little Dead Girl
 * Nightmares and Fairy Tales
 * Pepper Penwell and The Land Creature of Monster Lake
 * Rex Libris
 * Serenity Rose
 * Shadoweyes
 * Squee
 * Widgey Q Butterfluff

Studio Foglio

 * Buck Godot Zap Gun for Hire
 * XXXenophile
 * Girl Genius

Tekno Comix

 * Mr. Hero the Newmatic Man

Top Shelf

 * League of Extraordinary Gentlemen
 * Lost Girls
 * The Surrogates
 * Incredible Change-Bots

Topps

 * Lady Rawhide

Tower Comics

 * THUNDER Agents

Tundra Comics

 * Alison Dare

UDON

 * Street Fighter

United Feature Syndicate

 * Garfield His Nine Lives

Valiant

 * Nintendo Comics System
 * The Legend of Zelda
 * Magnus Robot Fighter
 * Quantum and Woody
 * Solar, Man of the Atom
 * Turok

Villard

 * Elks Run
 * Flight

Viper Comics

 * The Middleman

Wildstorm Productions

 * Desolation Jones
 * Global Frequency
 * North 40
 * Two-Step

Zenescope

 * Grimm Fairy Tales

Independently published

 * Action Girl
 * American Mcgees Grimm
 * American Splendor (though later picked up by Dark Horse and then DC Vertigo)
 * Body Bags
 * Bone
 * Bookhunter
 * Cavewoman
 * Cherry Comics
 * Chick Tracts
 * Circles
 * City of Dreams
 * A Distant Soil
 * The Desert Peach
 * Double Happiness
 * Dracula vs. King Arthur
 * Echo
 * Electric Girl
 * Elf Quest
 * Finder
 * Fritz the Cat
 * Funnyman
 * Garfield Minus Garfield
 * Gear (originally published independently, reprinted later by Image Comics)
 * Katman
 * Lady Death (technically, multiple publishers, including at least two defunct ones)
 * Let's Kill All the Belgians A Childs Guide To Genocide
 * Life Sucks
 * Limekiller At Large
 * Meanwhile
 * Mr. A
 * The Pertwillaby Papers
 * PS 238
 * Rapunzels Revenge
 * Reid Fleming Worlds Toughest Milkman
 * The Rocketeer (changed publishers every few issues, passing through Pacific, Eclipse, Comico, and Dark Horse before ending up with IDW)
 * Sonic the Hedgehog 1991
 * Strangers in Paradise
 * The Stuff of Legend
 * Tanpopo
 * Tank Vixens
 * Therefore Repent
 * Thieves and Kings
 * Too Much Coffee Man
 * Transformers Generation One Dreamwave
 * Transformers Timelines
 * Transformers Classics
 * Transformers Shattered Glass
 * Transformers Trans Tech
 * Transformers Wings of Honor
 * Treasure Chest
 * True Story Swear to God
 * Twisted Toyfare Theater
 * Underburbs
 * The Unfunnies
 * Vampirella
 * Vogelein
 * Warrior