Blessed with Suck/Video Games

"Etna: You've got until tomorrow morning. Understand? If you don't bring me the Ultra Dessert by then, well... you'll be begging me to let you explode! Capiche!?"
 * Shiki of Tsukihime gains the power to "understand the concept of death" after a near death experience as a child, which allow him to destroy almost anything within knife range, bypassing a variety of forms of Nigh Invulnerability (including reincarnation). Unfortunately, it also reduces his lifespan and health (somewhat variable depending on the route), puts increasing amounts of strain on his brain (to the point of threatening to explode the blood vessels) as he perceives harder and harder to comprehend deaths (buildings, undead, poisons,... ), and can't be turned off. Seeing a world that can seemingly crumble at a touch was terrifying when he first woke up with his power; if he had not been given indestructible glasses to block his eyes, he would have probably gone insane soon after. And his eyes will eventually become too powerful for even those glasses to contain...
 * Arcueid has this as well; she is easily the most powerful character in the game, able to summon a phase of the moon that will only happen 1000 years in the future into present reality. Anybody who she gets serious against will not last long. Problem: she has to use over 70% of her power to hold back her vampiric blood-lust from taking over and massacring everything.
 * Zasalamel in Soul Calibur III finds a way to render himself immortal, allowing him to reincarnate with all of his past memories and personality intact after each death. However, this also robs him of a peaceful death, and his soul gets eaten away by dark forces after each death and rebirth, forcing him to search for the game's MacGuffin in order to break the cycle.
 * In the following game, he comes to terms with his immortality after a vision of the future. He decides that it's better to use his "gift" to guide humanity down a good path and the end of his ending shows him living in the present day as a wealthy man, pleased with his progress.
 * Metal Gear:
 * In Metal Gear Solid, we got Psycho Mantis. He outright stated in his death speech that as a kid he was unable to shut off his powerful Mind Reading ability (learning that his father hated him, ouch), and that apparently looking too deep in too many minds of Serial Killers drove him off the deep end. Apparently he still couldn't completely shut off his Telepathy since he asked for his mask back to block the voices out, and complained about "How everyone thinks of only one thing". No wonder he became a Psycho!
 * Fortune in Metal Gear Solid 2: Sons of Liberty lost her father and her husband in quick succession, and the stress caused her to miscarry her unborn child. She was suicidal, but discovered she could not die: no matter how improbable, events conspired to keep her alive, cursing her with good luck. Explosives are duds, and bullets miss..
 * Pokey (Porky) the Big Bad of Mother 3, has a device known as the "Absolutely Safe Capsule"
 * It is also implied that,
 * In the Suikoden series, possessing a True Rune stops the character from aging any further and comes with a whole host of really spiffy abilities besides. Sounds great...but True Runes also seem to possess a will of their own, and tend to "force" their bearers into conflict. On top of that, there are many cases where even using (or unlocking) a True Rune's full power causes an additional nasty side-effect. Some examples:
 * In Suikoden IV,.
 * Not to mention that it's implied that the Rune itself orchestrates events around the bearer, so that they're FORCED to use it's power. Mostly in the form of making huge armies or powerful monsters attack the home of the bearer and easily threatening to kill everyone the bearer knows and loves. It only stops doing this if it goes into it's "Forgiveness phase" (as the Rune of Punishment governs both punishment AND forgiveness), but this is apparently an exceedingly rare event.
 * The Rune of Death in Suikoden earns its name by causing people close to the wearer to die and then eats their souls. On the plus side, the Soul Eater allows its user more powerful abilities every time it does so.
 * Suikoden V's Sun Rune causes  along with wielder-willed climate change.
 * This is not an inherent trait of the Rune, though, but is instead the result of an incident in the game's backstory that also resulted in the creation of the Dawn and Twilight Runes. Consequently, possessing all three runes mitigates the side effects of bearing the Sun Rune. Too bad that the Dawn Rune had been stolen before the start of the game...
 * The Moon Rune turns its bearer into a vampire. It takes a few years to get their bloodthirsty instincts under control, by which point they'll more than likely have killed a lot of people.
 * The Rune of Beginning is usually split into its two component halves, the Bright Shield and Black Sword Runes, which are usually borne by two close friends. The two Runes will compel their bearers to put them back together again by slowly draining their lives. To be merged back into the Rune of Beginning, the bearer of one must kill the bearer of the other and take their Rune. That's right, the Rune of Beginning will basically force its bearer to kill their own best friend.
 * Remember Luca Blight? It's very subtly implied that one of the reasons he was so Ax Crazy was because of the influence of the Beast Rune, which governs over "passion and bestial rage".
 * Don't forget the part where it eats people to power itself.
 * The elemental Runes actively attempt to cause their bearer to lose control of them. We don't know what happens with the other four, but when this happened with the True Fire Rune, it caused a massive explosion that wiped out both armies in the conflict it was being used in at the time and continued to burn for seven days and seven nights.
 * We know that Luc gets some fun post apocalyptic images/messages from his rune. And these are the ones that lack well documented curses!
 * The Night Rune currently takes the form of a talking sword. It's also rather arrogant and mouthy, and is prone to attacking its own wielder over real or imagined slights.
 * The King of the Sindar is the current bearer of the Rune of Change. As a result, the entire race is incapable of settling in one location for very long.
 * Conversely, The Circle Rune is in the hands of the Holy Harmonian Empire's High Priest Hikusaak has the powers of order and stagnation. Yeah, they've had centuries of peace and prosperity, but a decent chunk of their human population are little more than slaves, and the non-humans should be so lucky.
 * Harmonia goes even further with this trope given its tendency to revert to creation to maintain power. This is considered less than successful given that Luc
 * And proof you don't even need a True Rune to fit this trope in the game: Thomas. You'd think given he was  that he'd have some well deserved angst.
 * In Fire Emblem: Radiant Dawn, Michiah's "Sacrifice" ability is hyped in the storyline up as being unique and magnificent. However, in an example of Gameplay and Story Segregation, in-game the ability is only useful for level grinding and healing status effects as it uses up her HP. Combine this with the fact that she is already has difficulty taking a hit and you get a very bad ability.
 * However, when coupled with Edward's Wrath or Tauroneo's Resolve, Micaiah becomes an untouchable, double-attacking, always-criticalling power machine, making it a case of Cursed with Awesome.
 * All people who have one laguz and one beorc parent are examples of this. You age slowly, gain various abilities, etc. - oh, and you are an absolute pariah in both societies. And either you can go to the Laguz (who can sense you, and probably age even slower) or the Beorc (where you have to move around every few years) societies to live. There are quite a few of these in the list of main characters.
 * Mostly fixed after the game ends when
 * And of course, who can forget Planescape: Torment?
 * In God Hand, the main character Gene loses his right arm while saving Olivia's life, and is rewarded with having his arm replaced by the God Hand, a severed arm of a legendary fighter that grants Gene superhuman fighting skills. Unfortunately for him, the God Hand is extremely desirable to the villains, and Olivia has a bad habit of constantly sending Gene out to do her dirty work.
 * Oswald the Shadow Knight from Odin Sphere is the wielder of the Belderiever, an extremely powerful magic sword that gains power from killing and allows him access to a near-unstoppable shadow form. Unfortunately, the sword is cursed and the shadow knight power-up came from having Oswald's life and soul sold to the Queen of the Dead (and to make matters worse, Oswald himself didn't get any say in the matter; his foster father did it to him without his consent). Not only is he loathed by literally every living being on the planet and plagued by weakness as the dead pull on his soul; he cannot let the Belderiever out of sight or the shinigami will hunt him down, kill him and drag his soul to the underworld where he'll be the Queen of the Dead's plaything for all eternity.
 * Bloodline Champions has the Glutton bloodline, who underwent a ritual for their (very small) people when they were being horribly beaten in a war and forced into caves against a large group of bandits. This make them grow much stronger and larger than the rest of their people as well as giving them earth magic abilities... but made them perpetually hungry.
 * Ted Taylor, aka "Man-Bot", from Freedom Force was blasted by a massive dose of Energy X that causes his body to constantly generate the energy in large doses. This renders him the potentially most powerful superhero in existence, but his body is wracked by constant pain by the enormous amounts of energy that build up inside his body. In addition, he has to wear a specialized containment suit powered by his own energy emissions or the build-up of energy leads to irregular and painful detonations capable of killing people and leveling buildings. The suit is also limited in its durability, which means he's never truly able to cut loose and use his full potential either. To add to all that, he inadvertently killed his brother with one of his blasts by hesitating in taking up the suit, giving him a massive Guilt Complex as well.
 * John Morris of Castlevania Bloodlines is somehow related to the Belmonts, and as a result, is able to use their Vampire Killer whip. The catch? It drains his life energy, to the point where sometime after Bloodlines and before Portrait of Ruin (the direct sequel to Bloodlines), he dies.
 * In Final Fantasy III, Noah gave one disciple the gift of magic, another the gift of dreams, and the third the "gift" of mortality.
 * Any guesses as to which of these goes bug-fuck insane and tries to unleash the game's eventual Big Bad on the world? First two don't count.
 * To be fair, that was a dick move on Noah's part: "Let's see, I'll make the first one a master of magic, the second a master of dreams and the third a master of dying.
 * Final Fantasy VIII Ellone's born power does something involved with time, making her being wanted by bad guys ever since she's a girl. Her parents are killed, she gets kidnapped, being briefly placed as a science rat, and has to spend most of game escaping from Galbadia Army.
 * In Final Fantasy XIII the plot revolves around l'Cie, people chosen by the godlike fal'Cie to accomplish some mission. Being an l'Cie gives you special powers but means the most powerful government in the world wants you dead and you must figure out what on earth you are supposed to do and complete it within a time limit. If you fail, you become a cie'th, a monster of some sort that lives in eternal pain. If you succeed, you turn into crystal.
 * Vanille, Fang, Serah, Dajh, Lightning, Hope, Snow, and Sazh
 * Also,
 * Final Fantasy XIII-2 also has
 * The Big Bad is also an example.
 * Metroid Prime 3 has Hypermode, a Limit Break in which Samus becomes very powerful and invincible. But, it involves Phazon, so excess use of it will cause Samus to get slowly corrupted, and if corrupted far enough she will become terminally corrupted, leading to a Nonstandard Game Over.
 * Not as bad as it seems, because overusing Hypermode puts Samus into corruption mode, where terminal corruption is averted by expending excess phazon... by continuously firing the hyper beam just like in Hypermode. Essentially the only real suck is for anything that happens to be in her way, but then that's par for the course with Samus.
 * In-universe, it's implied that as Samus uses Hypermode more, the severity of her long-term corruption increases, but thanks to Gameplay and Story Segregation, this happens at the same rate regardless of how little or how much you use Hypermode.
 * Samus Aran herself is blessed with suck: found and raised by Precursors, she is able to manufacture by herself a personal gunship which can travel through the galaxy and has some impressive firepower, can hack through any computer, and is such a badass that the most ruthless, militaristic, intelligent race of the universe crap their pants when she is in the same solar system. On the other hand, she has to clean up the mess produced by the Chozo, will probably have to fight in a galaxy-wide conflict until her death, and any planet she sets foot on tends to explode.
 * Tales of Symphonia Colette's powers as the Chosen gives her pretty hard light wings and a cadre of powerful & useful Angelic Attacks. However every time she gains another power . She eventually  but luckily.
 * She also later suffers from
 * In more recent Pokémon games, certain natural abilities can function this way.
 * For instance, Klutz is an ability which doesn't prevent the Pokémon from holding an item, but rather from using it. This means that they can't pump up their attacks with stat-raising items. On the other hand, negative-effect items like Toxic Orbs and Iron Balls also don't affect them, and the Pokémon with Klutz can learn moves that make good use of those items.
 * And Pokémon Mystery Dungeon makes it so that each Pokémon has ALL of its possible abilities simultaneously -- good and bad -- AND makes several once-decent abilities worse. So now, Klutzy Pokémon can't hold ANY items, even the few they could before...Run Away makes a low-HP Pokémon panic and go into an uncontrollable retreat...and so on and so forth.
 * Lucario comes to mind. In the main games, it either gained speed when it flinched (the Steadfast ability) or was immune to flinching (the Inner Focus ability). In the second pair of Pokémon Mystery Dungeon games, Steadfast is completely nullified by Inner Focus.
 * Non-ability wise, we have Absol. Absol have the extraordinary ability to sense impending natural disasters, and naturally try to warn humans who are in danger. Humans mistakenly end up thinking that Absol cause the disasters and hunt them down for it.
 * Psyduck needs to have a painful headache to even use its powers.
 * Darkrai is also blessed with suck, as its Bad Dreams ability automatically does damage to any Pokémon who is sleeping. In some forms of Pokémon media, this is portrayed as a curse which has caused him to be feared and unable to interact with friends.
 * There are a few things like this in World of Warcraft, but a particularly interesting one is the case of Sir Zeliek, a paladin so strong in faith that even after a necromancer killed him and raised him as a Death Knight, he retained his own mind, will, and even his paladin powers. Problem is, the necromancer does control Zeliek's body, so while most of those who became Death Knights unwillingly (itself considered a Fate Worse Than Death) are obliviously Brainwashed and Crazy, he is a fully-aware puppet who begs forgiveness whenever he kills a player.
 * Taken a step further as his Light based powers cause him extreme amounts of pain whenever he's forced to use them.
 * Being a healer in PvP can evoke this feeling as any smart opponent will aim to take you down first. And then you get blamed by your teammates for not healing them.
 * Since each player can choose what role they want to specialize int, I think this is more a case of simple irony. The players most devoted to keeping people alive, and therefor unable to deal significant damage to the enemey, are usually the ones to die first.
 * Magic has a hint of this in the backstory, as it attracted the Burning Legion (and hence most of the trouble the world has seen) to Azeroth to begin with.
 * Brandon "Beyond the Grave" Heat, the protagonist of Gungrave. The necrolization process bestowed him with vast strength and agility, as well as the ability to regenerate from most wounds almost instantaneously. And he has not lost any of the skills with firearms he learned while alive. However, necrolization has completely ruined his memories, leaving them fragmented "snippets", and he has lost a great deal of his ability to feel emotion. And because his body is not much more than a reanimated corpse (albeit a powerful one), his whole body needs fresh blood periodically. In the game continuity,  The cost of having to meticulously preserve his body means having to stay sealed in a hibernation state for long periods of time, only to be brought out so he can blow something up.
 * In The Elder Scrolls series of games, there is a sword, Umbra, of which is debatably the best sword in the game, doing large amounts of damage and trapping the souls of enemies you fight, but it seems that if you would use this weapon long enough, it erodes your sanity, causing you to be aware of Umbra's hunger, and eventually the line between sword and wielder blurs. The character you receive Umbra from in Morrowind and Oblivion both refer to themselves as Umbra.
 * In Oblivion, there's the Grey Cowl of Nocturnal, a helmet that gives all sorts of bonuses that a thief would love to have. The problem? It was stolen from the Daedra Lord Nocturnal, and as punishment she cursed the Cowl; whoever owns it has their identity erased from existence. You could be wearing it and tell someone your name a thousand times, and they'll never hear it; any and all evidence that you ever lived magically ceases to be, and people will only remember you as the Gray Fox, the avatar of the Cowl.
 * This is actually extremely useful if you remember to wear the cowl while committing crimes. The guards will try to arrest you by default when wearing it in their vicinity but you can remove it in front of their faces, erasing your bounty and they will be none the wiser.
 * Shanoa, the protagonist of Castlevania: Order of Ecclesia, has this in spades. Her ability to command Glyphs gives her incredible power, including the ability to command the Dominus glyphs that each contain a piece of Dracula's power, thus giving her the ability to destroy Dracula. (Like he's not used to that by now...) Sweet, huh? Unfortunately, the ritual that GAVE her the ability to command those glyphs also took away most of her memories and emotions.
 * Silent Hill has the horrific example of Alessa. She was born with vaguely-defined psychic powers that included a link to the supernatural and "doing things" with her mind. As a result, she was tormented and abused by her peers and her mother, burnt alive as part of some unexplained ritual at the age of seven, then spent the next seven years in unending agony from burns that wouldn't heal, all for the purpose of summoning a being that would plunge the world into darkness. Even when she finally dies, she's merely reincarnated into another body so the ritual can be completed, with the implication that this will continue forever.
 * In Prinny: Can I Really Be the Hero?, Etna issues the titular Prinny a special scarf that stops him from exploding like Prinnies are known to do when tossed or handled recklessly - and then demonstrates it by kicking him into a wall. Sounds neat, right? THEN she drops this little beauty...
 * Silent Hill has the horrific example of Alessa. She was born with vaguely-defined psychic powers that included a link to the supernatural and "doing things" with her mind. As a result, she was tormented and abused by her peers and her mother, burnt alive as part of some unexplained ritual at the age of seven, then spent the next seven years in unending agony from burns that wouldn't heal, all for the purpose of summoning a being that would plunge the world into darkness. Even when she finally dies, she's merely reincarnated into another body so the ritual can be completed, with the implication that this will continue forever.
 * In Prinny: Can I Really Be the Hero?, Etna issues the titular Prinny a special scarf that stops him from exploding like Prinnies are known to do when tossed or handled recklessly - and then demonstrates it by kicking him into a wall. Sounds neat, right? THEN she drops this little beauty...

"Xigbar: ...We're not supposed to "be" in the first place. What's there to leave behind?"
 * In Runescape, Zanik is truly Blessed with Suck- she's a Dorgeshuun goblin, a tribe that fled beneath the earth when their god, Bandos, ordered them to fight a war they couldn't possibly win for fun. Zanik is the Chosen Commander of a prophecy, who will lead goblins to victory all over the world. However, the Dorgeshuun have become learned pacifists, so to fulfill the prophecy, Zanik would effectively get her tribe and thousands of other goblins killed. The entire quest 'The Chosen Commander' involves the player helping Zanik to escape this destiny, and after the two defeat Bandos, Zanik's friend Juna, a giant snake who is a Guardian of Guthix (god of balance), ends their friendship because of Zanik's defiance of her destiny (Juna says that since Bandos brought the goblins to Runescape, they were his, so Zanik should have gone along with him), which makes Juna a really nice "friend".
 * Alyssa from Clock Tower 3 could be considered this. She has a powerful bow that only works when she frees a certain spirit, is repeatedly dragged into other dimensions and chased by supernatural monsters, and is the target of her insane grandfather who wants to drink her blood so he can live forever.
 * A certain enemy of Final Fantasy X comes to mind. A reborn form of a previous boss you encounter has the always present Zombie status. The Zombie status makes it so that all spells and items that would heal you would hurt you instead, but gives you increased defenses and immunity toward Death. However, there is a spell called Life that brings a character back to life with full health. Zombie reverses healing moves to cause damage. Healing spells can be cast on enemies. Granted none of the team members you have can use Life at that point in the game under most circumstances, but then healing items do the same thing, leading to just dumping two Phoenix Downs (since it has more HP than the initial damage cap).
 * In Mana Khemia Alchemists of Al Revis, there is a powerful Mana aligned with the element of Light. Someone is desperate to pact with this Mana. After they did make a pact, the Mana makes it his job to publicly humiliate his "owner", whenever the Mana is bored and in need of entertainment, which is very often. The Mana even admits it to being his hobby. Simply put, bonding with the Mana of Light cements the poor fool into becoming The Comically Serious and Chew Toy status of the game.
 * Zato-One from Guilty Gear. He was given a demonic entity called The Eddie that made him very powerful and granted him control of shadows. However, the process blinded him, Eddie gradually began to take over his mind, and Zato found that Eddie was killing him (and succeeded at the end of Guilty Gear X). Millia Rage is starting to have the same problems.
 * Ryu from Breath of Fire: Dragon Quarter has the incredibly destructive dragon abilities - which, over time, cause him to lose control and die. Better still? The counter still ticks when the powers aren't in use; it just goes faster (sometimes abysmally so) when they are. And the icing on the cake: this counter can't be reversed. Ever.
 * In Persona 3, to fully control an all powerful shadow-fighting Persona, you must have the "potential", a trait only a few are born with. If you don't you have to take experimental suppressants with deadly side effects, and if you ever forget to take them, your own Persona will try to kill you or anybody around you. The poor guy with the worst of it is Shinjiro Aragaki. He leaves the group out the safety of his friends (and they still want him back anyway out of worry), forced to make shady deals with an assassination group to obtain above deadly suppressants, and learning the hard way what happens when a Persona goes berserk, you know who's blessed with suck.
 * Poor Daxter. While being an ottsel turns out to be quite useful throughout the course of the series, he's still got to deal with being short, hairy and itching in strange places. Although.
 * Freeware game Wrath of the Sea King has a premise built on this trope. The main character is a treasure hunter suffering from headaches so strong, they are driving him to suicide. He finds an amulet that makes him immortal - but the headaches remain, and he feels the pain of each death. Ouch. In the game itself, it translates in having unlimited lives, but the twist is, you have to die as less as possible if you want to see the complete ending sequence.
 * The Mages of Dragon Age are capable of many impressive feats, including shapeshifting and healing. They are also constantly under the threat of attracting Demons to the world, or worse, being possessed by one and turned into a mindless Abomination. Oh, and the local religion loves turning them into scapegoats... Not all mage possessing entities are malevolent, like a Spirit of Faith who saved the kind old woman Wynn, keeps her alive with her will intact, and helps her to heal people. Yet despite this possibility, benevolent spirits can turn into demons afterwords, like how Anders inadvertently transformed Justice into Vengeance.
 * The Grey Wardens are just about as screwed. Yes, they can detect darkspawn and are immune to the darkspawn's taint, but the darkspawn can detect them too. Furthermore, they're constantly plagued by nightmares, and due to their connection to the darkspawn . And in the end, to slay the Arch Demon . They also have great difficulty conceiving children with normal people. Conception between a male and female Warden is physically impossible. Awakening indicates that a mage Warden is more Cursed with Awesome, as the advantages of each cancel out the other's disadvantages, but that still doesn't say much for those not lucky enough to be born with the ability to use magic.
 * The Templars fare not much better. True, they are capable of cleansing the area from the demonic influence by sheer power of their will, but.
 * Feynriel in the sequel has it even worse than other mages. He is a somniari -- a mage with the power to enter and shape the Fade at will without an external power source such as lyrium or blood. This makes him an even tastier target to demons than normal mages and he has suffered horrible nightmares his entire life as demons assault his mind in the Fade. he will actually be receptive to being made Tranquil if it means escaping the demons. After a lifetime of nightmares and embodiments of emotion assaulting him, a dreamless and emotionless existence doesn't seem so bad anymore. But if you decide to help him control his powers,
 * As recently revealed in the 2009 Crimbo holiday in Kingdom of Loathing, whoever "runs" the holiday (normally Uncle Cimbo, but this year's Monarch was Don Crimbo) is destined "to give away everything and receive nothing.". This allowed the players to convince Don Crimbo to give up his ownership of the holiday and return to his other completely legitimate businesses, of which his accquisition of Crimbo was simply one of.
 * In both Left 4 Dead games, the survivors are all immune to the Green Flu that has been putting nearly everyone nearby them into zombie-like states. From all the story currently released, this seems to just be by luck of the draw that their immune systems can hold it off. Sounds nice until you realize that those infected appear to be in a rabies-like rage, are able to tell that the survivors AREN'T infected, and the survivors aren't immune to acid burns, strangulation, being beaten to death...
 * In one of the comics
 * Super Mutants from the Fallout series are massive, strong, forcibly-evolved humans immune to radiation and many diseases. However, they're sterile, frequently suffer rapid mental degeneration, and some of them (particularly the Nightkin) suffer from severe mental disorders, ranging from schizophrenia to full-on psychosis.
 * Mass Effect has Biotics, people born with latent telekinetic abilities. However, in order to be born with these abilities, their mother must be exposed to potentially lethal doses of Element Zero. Then there's a 70% chance the fetus will die of tumor growth. Then, the real problems begin. In order for the abilities to be anything but useless, Biotics must be outfitted with Biotic Implants which allow them to focus and control their abilities. This can lead to painful migraines and insomnia, and that's the least of their problems. In the early days of the Alliance, many biotics were drafted into a special military program, forcing them to go through Training From Hell to get the best use out of their powers. Kaidan will tell you about it if you ask him.
 * We also have the Drell, a race of reptilian-humaniods who can remember every moment of their life with perfect clarity (except for their birth due to it being so traumatic). They are able to feel sensations of past memories including kisses and other intimate moments, but also any physical or emotional pain. There is also a risk of Solipsism, trapping a Drell in a certain memory, this can include horrific experiences including gunshot wounds or torture. As Thane puts it, "Remembering times i've taken bullets is... unpleasant"
 * Ghosts in Starcraft. If you have those amazing Telepathy and Mind Over Matter, chances are that you will end up in Ghost Academy and be subjected to brutal training regimes that may even cost your life, ruthless indoctrination, and a memory wipe so that you become a mindless walking weapon.
 * Emil from Nie R, who gains tremendous magical powers, at the cost of his appearance; it turns him into a floating skeleton with a horrifying face.
 * Even before that, he had powers like this. His eyes could petrify anything he looked at...but he had no control over it. He ended up wearing a blindfold everywhere.
 * In the Kingdom Hearts universe, should The Heartless manage to tear your heart from your body, you may get a second chance at life as a Nobody if your will is strong enough. The only problem is that you can't feel any emotion, which is one of the functions of the Heart. Also, only the exceptionally strong-willed will retain their human appearance and memories, while the rest transform into warped and impossibly-shaped and constantly convulsing barely humanoid beings. The Nobodies are also considered "shunned" existences, for they do not have a heart to carry Light or Darkness and are essentially nothing. Xigbar puts it best in Kingdom Hearts: 358/2 Days when talking with Roxas about a fate of a Nobody when killed, disregarding the scenario of having their corresponding Heartless is slain.


 * Becoming a Werewolf in The Elder Scrolls verse is this for some of them. Lycanthropy technically is a blessing, being a "gift" from the Daedric Prince of the Hunt Hircine that imbues a mortal with Hircine's power. Werewolves can transform into very powerful beasts and have total immunity to disease, though their beastblood prevents them from ever having a good night's sleep and they have to maintain great willpower to avoid going feral. But upon their deaths, the Werewolves' lycanthropy manifests as spirit wolves that drag their souls to Hircine's realm, where they join his endless Hunt. lycanthropy is this trope and they want to be cured.  love being Werewolves and actually look forward to being part of Hircine's Hunt in the afterlife.
 * At the end of Golden Sun: The Lost Age, the Golden Sun event grants vast power increases to present Adepts, heals the dying Adepts present, and slows aging. Kraden, who was neither Adept nor dying, gets extremely slowed aging to the point of being immortal. Kraden was, at the time, over seventy. Nearly everybody who encounters Kraden in Golden Sun: Dark Dawn, thirty years later, comments first on the fact that he isn't dead yet, and then on how much it must suck to live forever as a feeble old man.
 * The plasmids in bioshock. sure you get awesome superpowers, but not only do you get extremely disfigured from them, and can get addicted to them.