Xkcd/Tear Jerker


 * Probability, especially for relatives of cancer victims and moreso after Randall himself later announced that his fiancee has breast cancer.
 * Lanes, especially the massive final panel. The Alt Text just drives the point home further...
 * As a lymphoma survivor, this comic made me cry like no other
 * Spirit
 * For extra anthropomorphism point, consider Spirit's mission patch. You did well, lad. We're so proud of you.
 * Helping
 * Well
 * Science Valentine
 * Temper For anyone that grew up with this man. If you didn't cry at the comic, then you will at the Alt Text.
 * Dark Flow, especially for anyone who lost a parent. Even more especially a mother.
 * Diode The Alt Text makes it even worse.
 * Secrets
 * "Will it ever stop hurting?"
 * "but secretly we're just afraid to tell it to love"
 * Although it does have a relieving Mood Whiplash via the Alt Text.
 * Forgetting
 * Eternal Flame Especially the alt text. Steve Jobs.
 * Laser Scope. It may be strange or funny at first but then you read the alt text...
 * Friends... Dear mother of God!
 * Dream Girl, although this may help.
 * In a similar spirit: Etch-a-Sketch.
 * Nightmares. Part Tear Jerker.
 * The Barrel Boy story, especially these three.
 * Never. Most of these at least have a sense of humor, but this... doesn't.