Forbidden Chekhov's Gun

"Egon: "Don't cross the streams." Peter: "Why?" Egon: "It would be bad." Peter: "I'm fuzzy on the whole good/bad thing. What do you mean, 'bad?'" Egon: "Try to imagine all life as you know it stopping instantaneously and every molecule in your body exploding at the speed of light." Ray: "Total protonic reversal." Peter: "Right. That's bad. Okay. All right. Important safety tip. Thanks, Egon.""

- Ghostbusters

Remember Chekhov's Gun that was on top of the mantel? The one Little Bobby was told never to touch, under any circumstances? Now's the time to grab it. This is a specific subtrope of the Chekhov's Gun where some points out the "gun" and explicitly warns against using it. It doesn't have to be a Matter of Life and Death. It can be as simple as being told not to push a button, then later being told to push it.

In general, whenever someone says "Don't touch that, it's in case of extreme emergencies", it will be used in an extreme emergency later on. As a desperation maneuver, it invariably works. (Remember, desperation maneuvers ALWAYS work.) In fact, if a character at any point says, "Don't ever do that!", it's ten to one that very thing will happen by the end of the story (whether on purpose or by pure accident).

Often used in conjunction with a Godzilla Threshold. Mildly related to Explosive Overclocking, Temporal Paradox, and Finishing Move.

Anime

 * Aban from Dai no Daibouken developed Grand Cross as a Godzilla Threshold skill. He specifically states that it's only intended to be used when everything else has been tried, which warns the viewer this skill will only be used at a story climax.
 * Slayers offers another example with the Giga Slave. In order to keep it from being Lina's answer to every problem, a Godzilla Threshold aspect was introduced. Lina learns that the spell could cause the world to turn to chaos, and vows to never use it again; naturally, she's forced to do so at the end of Slayers Next.
 * Interesting to note, however, is that it's not always used when there's a climax. The end of the first season, like the end of NEXT, is one big attempt to get her to perform the spell. She doesn't. Almost the entirety of Try, once the characters learn who the Big Bad is, is about finding a way NOT to use it. They succeed, but Lina always accepted that she may have to use the Giga Slave if their plan didn't work.
 * Sugata of Star Driver has access to an extremely powerful first phase ability, the King's Pillar. However, every previous bearer of Samehk's mark who used the ability never woke up again. Of course the time comes when he has to protect Wako, and well, you can guess what happened. Luckily for Sugata, his libido was strong enough overcome that effect.

Comic Books

 * In the Flash storyline "Terminal Velocity", Wally has various reasons to believe that pushing his superspeed too far is a Godzilla Threshold that will draw him into the Speed Force, never to return. He tries to avert a conflict which he knows will force him to do this, but to no avail. However, when he does finally enter the Speed Force, he manages to return (which no one has done before) thanks to The Power of Love.
 * In the Asterix comic series, Getafix does not allow Obelix to drink the magic potion, as he fell into the cauldron as a boy, and an extra helping could have bad effects on him. But in one story, Asterix and Cleopatra (both the comic book and the animated version), Getafix gives him just a drop of potion to give him extra strength in a difficult situation.
 * Also overlaps with Godzilla Threshold.
 * Fone Bone, Gran'ma Ben, and one of the Dreaming Masters were the only people who didn't want to do it, but near the end of Bone, the Crown of Horns seems to be the only way out, even though it's been said that if Thorn even touches it, all of existence would be in jeopardy, and the trip there would be dangerous anyway with all the dragons that guard the Crown of Horns and intend to kill anyone who's anywhere near it.

Film

 * Ghostbusters has the iconic warning "Don't cross the streams," which they inevitably have to do at the end of the movie. As former Trope Namer, it was also causing confusion, since this overlaps with Godzilla Threshold. In this case, the non-disaster when they do end up crossing the streams makes internal sense: they are firing into a.
 * In Orgazmo, Choda Boy swears off using his dangerous "Hamster Style" at a young age due to its unpredictability, but at the movie's (heh, heh) climax, he employs it with great results.
 * Agent J in Men in Black is told by Agent K to never, ever touch the red button inside their car. When the two need to get across the city in a hurry and the tunnel is jammed, he is told to at last push the button—transforming the car into a high-speed rocket that drives along the ceiling of the tunnel.
 * In the second movie Jay uses "Pressed the Red Button" as a type of code, indicating that it is reserved only for the biggest emergencies. They seem to prefer to not even use the neuralyzer if they don't have to, so going for a rocket car ride would likely be a last ditch number on their list of priorities.
 * The Omega 13 from Galaxy Quest. Somewhat played with. None of the characters even know what it does, including the aliens who built it. So they don't want to use it, because they don't know what it will do.
 * The Gunstar's Death Blossom attack in The Last Starfighter; not so much that's it's insanely overpowered (although it is) as that it leaves the ship vulnerable just before and after it's engaged.
 * Iron Man 2, kind of. When Iron Man and Rhodey fight in Tony's villa, they both fire their handcannons at each other at the same time and basically cause a huge explosion, a dangerous side-effect they hadn't predicted. So a Show, Don't Tell version of the warning. This is then used later on to take out the Big Bad when he has the upper hand.
 * In the Lost in Space film, ships have hyperspace engines, but it is not a good idea to jump without coordinates or a jump gate as the exit vector would be random. The crew does this anyway when the ship is sabotaged and crashing into the sun.

Literature

 * Terry Brooks plays this straight in most of his fantasy novels, especially the Magic Kingdom of Landover series. Generally, his protagonists have access to powerful magic that defeats or destroys their enemies. However, every time they use it, they get a feeling that one day, they will "lose themselves" to the magic. In a subversion, this never happens.
 * In the novel Foundation And Empire, Devers is trying to escape Trantor, with the police in hot pursuit, since . He enters hyperspace very close to the planet, which could kill him.
 * The Door to Nowhere and Nowhen serves this function in The Redemption of Althalus.
 * Discworld
 * In The Colour of Magic, one of the eight spells (eight is an important number on the Disc) has lodged itself in Rincewind's mind. He doesn't know exactly what it does, but popular wizarding opinion is that it will destroy the Disc. As a semi-sentient entity, it tries to cast itself. Rincewind barely prevents himself from casting it several times through the course of the first two books (which is one story) The Colour of Magic and The Light Fantastic.
 * In the back-story of Going Postal, an automatic letter-sorting device with extradimensional components (it accesses a dimension where pi is exactly equal to 3) goes out of control, filling the Ankh-Morpork Post Office with letters. Wizards called in to inspect the device warn that shutting it down is likely to destroy the universe. Fed up with the machine, a veteran mail-carrier starts smacking the device with a crowbar until it shuts down. When the mail-carrier started hitting the device, the wizards ran away. As the doer of the deed testified; unless they had some other universe to run to, they weren't really sure about the danger. The wizards insist that the universe really was destroyed, but was instantaneously replaced by a complete, identical universe.
 * An unusual example, in that this was a ending-the-universe danger, but never actually crossed the Godzilla Threshold before it was destroyed.
 * The Chronicles of Thomas Covenant (at least the second one), after spending the last two series trying to prevent Lord Foul from obtaining Covenant's white gold ring in the final confrontation
 * Thursday Next has something to break in event of "unprecedented emergency"—with the explicit note that your death is not an unprecedented emergency.

Live-Action TV

 * Babylon 5: The "Bonehead Maneuver" as mentioned in the Season 3 premiere. Basically, you have two ways of going in and out of hyperspace. If your ship is powerful enough, you can open your own jump point, or, if your ship isn't that powerful, you have a Jump Gate open one for you. You never want to open a jump point inside a jump gate, because this causes one massive explosion of a Negative Space Wedgie. Aside from the loss of a very-hard-to-replace jump gate (typically a star system will have one at most) and potentially stranding people in the system if they lack massive starships, this doesn't actually cause any huge universe-altering affects. Just a huge explosion that is difficult for most ships big enough to open a jump point to outrun (so, not really a Godzilla Threshold). They end up using the trick in a tricked-out new spaceship that might be fast enough to get away after using this trick to kill an enemy they definitely weren't big enough to fight.

Radio

 * In The Hitchhiker's Guide to the Galaxy, it's generally a really bad idea to activate the starship Heart of Golds Infinite Improbability Drive without proper programming, as literally anything' could happen as a result. However, when confronted with imminent destruction by a pair of nuclear missiles, Arthur Dent goes ahead and does it anyway, since almost anything else would be an improvement. Luckily, the only thing that happens this time is a redecorating of the ship's bridge, and the two nuclear missiles being replaced by a live sperm whale and a bowl of petunias. (Also occurs in the book, TV series and movie adaptations.)
 * If we knew why the bowl of petunias thought "Not again!" while falling, we would probably understand a lot more about the universe. It Makes Sense in Context.

Tabletop Games

 * Warhammer 40,000 gives us the Spear of Twilight, which will doom whomever removes it from stasis to death from a wasting curse. Prince Yriel saved his Craftworld from being eaten by Tyranids by using it.

Theme Parks

 * In the Men in Black: Alien Attack ride at Universal Studios, a Big Red Button like the one mentioned in the above example appears in every ride car. Like in the film, you are told never to press it. However, by the end of the ride you face a giant alien that's immune to your weapons. Guess what you have to do?
 * A cheesy instruction video seen while in line on the ride explains exactly why you don't press the button; it's basically a nuke capable of frying the more Kaiju-esque aliens.

Video Games

 * Press X to Die is a video-games-specific instance of this, in which the game will really be over if the player actually fire the forbidden gun. Usually, the gun is some kind of weapon of mass destruction.
 * In the first Shadow Hearts game, all characters have a Sanity stat during battle. If this reaches zero, the character goes berserk, attacks their allies, and will not gain experience if you win the battle. The strategy in many difficult battles involves keeping this stat up while various effects suck it away. How does one unleash the final, most powerful transformations of the main character? By leveling the transformations up to max and then going insane while fighting in them. Something of a Guide Dang It.
 * In the Ultima series, the Armageddon spell (which kills everything and destroys the entire world when cast) has always just been used as a Red Herring to give the player a Nonstandard Game Over, but by sealing oneself inside the separate universe made by a Barrier of Life spell with the Big Bad in Ultima IX: Ascension, the player is able to destroy just the universe he's in right now, along with his opponent and himself.
 * The entire Halo trilogy had you attempting to prevent the Halos from going off. Guess what the last level has you doing? Mind you,  but the concept remains the same. Cortana even handwaves it.
 * That one was completely justified: the Halos are meant to kill all life in the galaxy.
 * In Breath of Fire: Dragon Quarter, Ryu must unleash D-Breath against until the D-Counter hits 100% to trigger the final scene - an action that earns a Nonstandard Game Over everywhere else.
 * Destroy All Humans! 2 this trope is played for laughs in one of the final missions. In order to stop the superweapon going off, Crypto must cross the beams of a targeting system. The entire Ghostbusters conversation is used verbatim on why this would be a bad idea.
 * In Castlevania: Order of Ecclesia, using the Guess what you have to do to beat the final boss?
 * Though, as a result of some Applied Phlebotinum,
 * Fate/stay night. Specifically, using Excalibur, the first Deus Sex Machina (maybe), Shirou's arm, taking on Caster/Kuzuki directly on their turf (not a dangerous technique but the strategy is essentially suicide) and projection in general. Maybe it would have been best to simply leave this with no details considering how prominent this is?
 * Tsukihime: "Shiki, you've got about thirty seconds before Roa takes over your mind? What are you going to do now?" Answer: Stab himself in his own point of death on the assumption that if his will is stronger than Roa's, he'll live through it and Roa will die instead. Still, it's not like Ciel had any other ideas, and Arcueid provided backup by way of a single drop of her blood. (Thus sharing her will with his and allowing him to overpower Roa with relative ease.)
 * In Pokémon - Perish Song. Especially if you're in a double battle.
 * Magicka allows you to do this quite literally with the Arcane element and other elements to alter the beam's qualities, resulting in a combined, powerful beam. But if beams of opposing elements cross, a huge explosion occurs that will likely kill anyone nearby. Players may exploit this when fighting goblin shamans and other enemies that use beam attacks, intentionally or accidentally.
 * In Final Fantasy VIII,
 * In Chrono Cross, the Big Bad is defeated by literally crossing the time streams.
 * Happens again in Ghostbusters the Video Game,
 * The Great Clock's purpose in Ratchet and Clank Future A Crack In Time is specifically stated several times throughout the game to be maintaining time, not reversing it. Time-travelling with it would cause the entire universe to collapse on itself. Naturally,.
 * The command that stops the Big Bad from sacrificing you to end the world in Trilby's Notes is
 * Metroid: Other M combines this with A Taste of Power for the . You test them out in the beginning of the game, and are promptly told to never use them, and in fact attempting do so will fail. Also a Guide Dang It since you have, most likely, completely forgotten they exist by that point and wouldn't think to use them after all the hubbub about not using them previously.
 * Metroid: Other M combines this with A Taste of Power for the . You test them out in the beginning of the game, and are promptly told to never use them, and in fact attempting do so will fail. Also a Guide Dang It since you have, most likely, completely forgotten they exist by that point and wouldn't think to use them after all the hubbub about not using them previously.

Web Comics

 * This is the same way 8-Bit Theater character Red Mage's Ice-9 spell (a reference to the novel Cat's Cradle) works: as the description puts it, it removes all heat from the universe it is used in, thus destroying all energy. He can only use on other dimensions, like a bag of holding that he shoved an enemy in which White Mage then smashed with a hammer.
 * Bob and George's ultimate team-up attack is named as such, and is described by Bob that it'll definitely kill Mind, but might kill him, George and Dr. Light in the process. They decide to attack anyway. Bob and George first shoot streams of fire and lightning energy at Mynd, then Bob channels his fire into George, the end result being exponentially more powerful than the two alone.

Web Original

 * Played for laughs in A Very Potter Musical in which Harry shouts: "don't cross the streams!" when the trio summon their Patronus.
 * And Milfoy Malloy  Count Chocula Malfoy. But the dialogue the Ghostbusters use is used in AVPM as well, though to dicuss why Harry has to compete in the House Cup tournament rather than beam-crossing.

Western Animation
"Peter: "Egon, this reminds me of the time you tried to drill a hole through your head." Egon: "That would have worked if you hadn't stopped me.""
 * Johnny Test: Johnny teams up with some villains to save the Earth, and they're told right before they head out to not use their powers while holding hands, since it could multiply their powers by 500% or something. Naturally, when their plans are thwarted, they turn to this. It sounded like the villains refused to do this, and Johnny teamed up with his... dog.
 * The dog can talk, and they always team up.
 * They did this gag before. "We have to cross the creams!"
 * In Over the Hedge, characters tell Hammy not to drink caffeine, it could be dangerous to him, as he's already hyperactive. Later, they tell him to drink caffeine to go in Caffeine Bullet Time mode.
 * In one episode of The Real Ghostbusters, the GBs were falling toward a body of water from high enough to kill them on impact. Egon's solution? Have them fire at the water and cross the streams; the resulting explosion kicks up a huge column of water which breaks their fall enough for them to land safely. Upon landing safely, one of them asks how Egon knew it would have that effect. Egon's response? He didn't; he just thought it might help. We are talking about a guy who engaged in this exchange;

Real Life

 * The Manhattan Project. Scientists did experiments seeing how close they could get radioactive cores to going critical without actually making them go critical. They called this "Tickling The Dragon's Tail", and considered it a necessary but insanely dangerous thing to do. One core did accidentally go critical (very briefly) on two separate occasions, resulting in the deaths of two researchers and less severe cases of radiation poisoning for several others. They dubbed this one the Demon Core.
 * And I'm sure we all can see when they would feel it appropriate to let the cores go critical, but such circumstances are very rare and very controversial.
 * The Higgs Boson A.K.A The God particle. The way to discover it could turn Earth into a black hole.
 * Or cause the vacuum of space to drop to a more "stable" state, destroying the universe as we know it.
 * That's according to weirdos and pseudoscientists.
 * They found one on 14 March 2013. Earth didn't turn into a black hole.
 * Albert Einstein once observed that "you cannot simultaneously prevent and prepare for war."