- Hey, It's That Voice!: Patrick Warburton is Titan.
- The Other Darrin: In the first film, Ham was voiced by Andy Samberg. In the second one, Tom Kenny took over.
- Likewise, both Kilowatt and Zartog have their well-known actors (Kristin Chenoweth and Jeff Daniels) replaced with Laura Bailey and John Dimaggio (the former sounding stunningly annoying and the latter sounding bored like no tomorrow. Which is a shame since they voiced Lust and Bender).