Calvin and Hobbes/Awesome

Many for Hobbes. Basically any time he provides clever commentary or attacks Calvin returning from school.
Calvin's babysitter Rosalyn got one in her final appearance. After previously having to resort to threats and brute force every time she babysat Calvin, she finally beat at him at his own game, literally. The moment she realized that the purpose of Calvinball is to make up new rules all the time, she immediately got into the game and eventually used it to make Calvin go to bed without any more fuss.

Calvin: Man, she picked up the nuances of this game fast!
Rosalyn: Ha! This is fun!

Calvin and Hobbes' very last Sunday strip. "Let's go exploring!" Not to mention that it's a Heartwarming Moments.
- The real Moment of Awesome in "Let's go exploring!" is that it's probably the most remembered final line in any newspaper strip.
Any of Calvin and Hobbes' arguments. That one croquet match comes readily to this troper's mind...
Susie inviting not Calvin, but Hobbes to her birthday party, writing on the back of the note that he "could bring that stupid kid you hang around with if you like".
Calvin of all people getting an "A" on a paper. Considering his grades?
- In certain subjects like creative writing, he was nothing less than a savant.
Not really a Shout-Out, but Tengen Toppa Gurren Calvin must be mentioned.
- Holy shit. D'you think Calvin inspired Kamina?!
  - Calvin once outgrew the galaxy. WHO THE HELL DO YOU THINK HE IS?!?!?!
    - Someone who once landed on Mars in a toy wagon. ...That settles it.
Every time that Calvin got an insult in at Moe.