Dollhouse/Tear Jerker

Joel Mynor and his wife Rebecca (imprinted into Echo) on Dollhouse in "Man on the Street" (1x06), especially the end of that episode, when he gets to welcome his "wife" to the new house she never got to see (the real Rebecca died in a car crash on her way there). He's a creep, but he's a sweet creep.
- What resonated with this troper was Echo, in her supposedly inactive persona, choosing to be sent back to Joel to complete the engagement. Brings a whole new dimension to her joy in the final scene.
- Revisited at the end of "A Love Supreme" (2x08) when Echo becomes "Rebecca" once more, to give Joel "her" blessing to remarry.
In "Needs", the scene that shows Sierra and Victor promising to find each other no matter what happens, November weeping at her daughter's grave, and Echo leading the Actives above ground. The latter not so much sad tears, but more from the beauty of the scene.
Paul's brain-death, straight after he and Echo fell in love with each other. Not fair!
The scene in "A Spy in the House of Love" (1x09) Mellie/November, in Manchurian Agent mode, tells Paul she's an active.

Speaks-through-November: I have a message for you from inside the Dollhouse.
Paul: This isn't funny...
Speaks-through-November: My name is November.
Paul: Mellie. Your name is Mellie.
Speaks-through-November: I knew this would be hard for you to hear.
Paul: I'f you're pissed I'm still investigating the Dollhouse-
Speaks-through-November: This body belongs to a doll.
Paul: -just tell me. Don't do this.
Speaks-through-November: I'm sorry we had to deliver the news to you like this. In this body. The Dollhouse is likely to discover we've been placing messages in their imprints; this is the only way we could talk to you.
Paul: [shaking his head] They did this to you...
Speaks-through-November: They did this long before you knew me. They've been using this body to spy on you for months. The only reason Mellie exists is because of you.
Paul: Aren't I special?

The scene goes on and it's all so sad and you can feel Paul's heart breaking. Poor thing.

- And when she goes back to normal... Ouch. "Then why aren't you kissing me?"
"A Spy in the House of Love" fucked my tear ducts up. And my sense of right and wrong. Every time I watch the episode I want Adelle to be able to keep Roger so badly. No fair making me root for a rapist show.
- Repeated at the start of "Stop-Loss" (2x09). Adelle brings back Roger the night before Victor is to regain his freedom as Anthony, but Roger spurns her because he loves another (Sierra), then assures Adelle she's "too good" to need to bed an Active. Adelle breaks down sobbing.
The end of "Haunted" (1x10), when Margaret-in-Echo prepares to have her imprint erased. She asks if she will see her whole life flash before her eyes, and Adelle has to watch her friend die for the second time - and starts to cry as the wipe begins.
- I was more affected by her friend's husband. Poor dear...
  - This is a more subtle tearjerker, but we also should note that during that episode, Margaret was literally within arm's reach of her beloved husband Jack - but, poignantly, could never tell him so because she couldn't blow her cover. (Though she slipped once - after Jack was wounded helping to take down her murdering son Nicholas, Margaret instinctively ran to him and shouted "Darling!" before catching herself.)
Claire confronting Topher about her being an active, toward the end of "Omega" (1x12): "I don't see why it was so important for me to hate you." Not to mention, Topher sounds on the brink of tears for the whole of the ending montage.
In the episode "Haunted", when Topher borrows Sierra for a "diagnostic check." He implants in her the personality of a fellow geek. But it's at the end of the episode when it's revealed he did so to have someone to celebrate his birthday with...
- And at the end it turns out that Adelle knows he's doing this, but lets him anyway, essentially to keep him sane.
- Her voiceover at the reveal is heartbreaking.

Adele: "Loneliness leads to nothing good. Only detachment. And sometimes the people who most need to reach out are the people who are least capable of it. In any case, it only happens once a year."

This troper got teary-eyed at future!Topher's breakdown in "Epitaph One", as Adelle hugs him and tells him it's all right. "I know what I know, I know what I know, I know what I know..."
- This troper was caught a few seconds earlier on the "Promise me you won't answer the phone!" line.
- What brings makes my eyes sting, is when Whiskey says she has to wait there, and we remember Boyd telling her he would be back for her after their tearful parting. He won't be back. And not only that, the Boyd she fell in love may or may not have been a lie - Well-Intentioned Extremist with shades of Father Figure at best, a Nietzsche Wannabe at worst. Damn you, Whedon.
- This troper spent most of that flashback in tears. Adelle is so broken and yet still Adelle, and it is only because she is so broken that she can finally be the mother figure to Topher that she always could be. That entire flashback is so heartrendingly beautiful.
- Whiskey: "Was I my best?" Caroline-in-Iris: "Better."
  - What makes this so sad is that it follows directly after the episode where Doctor Saunders found out she was actually an imprinted Whiskey. In that episode, her refusal to freak out or start doubting herself was nothing less than a Crowning Moment of Awesome, so seeing Whiskey back in that blank Doll state is crushing.
- Hell, "Epitaph One" was basically a tearjerker from when Caroline woke up in the little girl's body until the end. Her getting all excited to see Claire Saunders and finding out it's Whiskey instead. "Was I my best?" That gorgeous song played over the last few minutes. Whiskey refusing to leave and then just sitting down and letting herself be gassed with the bad guys. Caroline's summation of the apocalypse: "Kids playing with matches. And they burned the house down." The Remembrance Wall and the pictures of Victor, Sierra, November and Echo. And finally, Caroline and the surviving rebels climbing the ladder and hoping it will lead them to Safe Haven, and that it still is a safe haven.
Vows. If you get through Claire's incredible amounts of bitterness and pain in her scene with Boyd, then don't worry, there's still her and Topher having near-simultaneous, award-worthy complete breakdowns from guilt and self-hatred...
"Belonging". Pretty much everything about the Sierra/Priya storyline. And Topher was heartbreaking too.

Priya: "This secret we have... can you keep it?"
Topher: "I can keep it. But I don't know if I can live with it."
Priya: "I know I can't. But I don't have to."

- Not to mention Sierra, after being wiped again, smiling innocently - with Priya's last tear still on her face.
- the very beginning of "Belonging"—Topher crying and saying something along the lines of "I only wanted to help her!"
- Echo seeing Victor, who had told Sierra he'd 'wait right here' for her until she got back, sitting in the same location - not realizing that Sierra was gone permanently.
"Getting Closer": Topher seems like he's finally happy, Saunders comes to talk with Bennett for a moment in what seems like a Pet the Dog moment... and then she shoots her in the head just as Topher comes back into the room. Topher's Heroic BSOD - "We can bring her back, we can bring her back" - doesn't help.
- His subsequent conversation with Ivy, especially considering their relationship thus far and the fact that we don't know what happens to Ivy after this, is part this and part Crowning Moment of Heartwarming.

Topher: I got it from here. You take your chance, you slip out. In the real world, you can write your ticket any place you land.
Ivy: I really do want to help you.
Topher: Then live! You have a remarkable brain. I think it should stay in your head. Ivy, don't become me. Go. Go!

- The revelation that Boyd, this troper's favorite character and sweet-and-soft Papa Wolf was actually behind Rossum, was enough to reduce me to tears. Damn you Joss Whedon and your plot twists too!
"The Hollow Men": Even Caroline was crying when she sent Boyd to his death.
- Mellie? Please, everyone, don't forget Mellie!
  - Especially her turning around so Paul wouldn't see her crying.
The end of "Epitaph Two: Return," particularly Topher's Heroic Sacrifice, and Echo "reuniting" with Paul. Before that, Echo's tirade toward Priya for avoiding Anthony and its segue into her own total breakdown over Paul's death, and her regret for not fully showing her love for him while he was alive.
- Five words: "Your job is way harder."
- And for some happy tears, try the scene immediately after the Echo-Paul moment, when we see Priya, Tony, and their son together as a family. Having the parents give little Tony one of the children's books they used to read when they were dolls is a wonderful touch, indeed a taste of Fridge Brilliance.
- This troper burst into tears watching Topher take notes from Bennett's instuctional video, then pause it, put his finger over her mouth and thank her. This probably had something to do with watching the last three episodes in one go.
- This Troper was literally speechless after Topher's Heroic Sacrifice. Right before he was hit, he said "Huh," almost like he was sane again. (Not to mention, Topher was this troper's absolute favorite character.)
Saunders killing Bennett hit me so hard that I still haven't been able to watch the last two episodes of the show.
Rossum and Senator Perrin betraying Madeleine at the end of "The Left Hand" by "proving" that she was mentally unstable and that her memories of the Dollhouse were actually the result of brainwashing, and that instead she was in a psychiatric hospital for three years.