A young child of either gender who is sought after by both the bad guys and the good guys for more than one reason. They may be The Chosen One, or holding the key or the secret to something, That makes this kid one of a great importance to all around him or her...
- In Franken Fran, a girl is this to a sect. The building of the sect becomes her body. Then she gets pregnant. And when the embryo awakens, mother and child merge to become the Flying Spaghetti Monster.
- Azumaria from Chrono Crusade.
- Madoka Kaname from Puella Magi Madoka Magica has a huge potential to become a powerful Magical Girl. This drives a lot of the conflict, as Team Pet Kyubey wants her to take up the role, but Dark Magical Girl Homura wants to stop her from doing so, going as far as shooting and killing Kyubey right when she decides to make one. Eventually we learn that in this setting Holy Child also means Apocalypse Maiden.
- Hikari / Kari, from Digimon Adventure. Hunted by Myotismon because she's the eighth digidestined and the holder of the Crest of Light. Heck, one of her image songs is even called "Holy Light."
- Harry Potter in the first book.
- In the Dune universe, Alia Atreides was considered this when she was a girl. After she grew up and became a tyrant, not so much. Also, Leto II and Ghanima as children.
- Pomma D'ok and Teera Eld in Zilpha Keatley Snyder's Green-Sky Trilogy. After they manage to connect with each other telepathically and rediscover important psychic abilities, some lost to their people for many generations, they are literally named Holy Children and worshiped by most of the people.
- Stargate SG-1 used it a couple of times, first with the Harsesis and later with Adria.
- The X-Files has Baby William, who is heralded as this. He is described as "more human than human", a normal human child with none of the human frailties. He is seen as the salvation of the human race from alien invasion; he is the epitome of what the Syndicate has been trying to do for years: create a human/alien hybrid. While they did it in a lab (with diastrous results), William was gestated naturally. If they can figure out to replicate that, or make a vaccine against the alien virus, the human race has a chance of surviving. So, they're after him. And the Super Soldiers, who are bent on making sure alien invasion is swift and that resistance is futile, are after him to kill him. On top of that, he is kidnapped mid-season 9 by a UFO cult who are convinced he is connected to a UFO they found. He has supernatural powers, most notably telekinesis. He is seen making the mobile above his crib move on its own (scaring his mother to death in the process).
- He also has a Christ-like birth, with Scully giving birth in a shack in the middle of nowhere, a guiding star, and the Lone Gunmen acting as the Three Wise Men. Though it took place in mid-May, not December.
- Angel: A few of these crop up during the series, notably in the series 2 episode "Judgement" and the series 5 episode "Time Bomb".
- Sheba is considered one in Golden Sun.
- That kid in the Villagers game.
- A somewhat older version is the teenaged Diadora from Fire Emblem Jugdral, since if she ever gave birth, there would be a high chance for said kid to be a vessel for a Dark God.
- The center of the conflict in Fahrenheit (2005 video game).
- Mithra from Asura's Wrath can freely manipulate Mantra to a point where she can be used as apower source to increase the power of the deities. And is apparently the perfect vessel for The Golden Spider to regain his full power.
- Aang from Avatar: The Last Airbender.
- King of the Hill episode "Won't You Pimai Neighbor?": Bobby is thought to possibly be the reincarnation of Lama Sanglug. The monks display several items on a blanket, and Bobby is to choose from any item that he sees. If Bobby is the Lama, he will choose an item that was the possession of the Lama. Bobby doesn't want to be a monk, so he chooses Connie, whom he sees in a mirror amongst the items. The monks accept this and leave...but the mirror was the item the Lama owned!
- Subverted (in the respect of "child") in an episode of Jackie Chan Adventures where holy monks believe Tohru is their reincarnated Chosen One. Played straight towards the end when it's clearly shown to be Jade.