Kingdoms of Amalur: Reckoning/Awesome

The end of most of the major quest chains, but especially the faction quests. They usually involve killing enemies that have proven undefeatable for centuries.
The finishing blow against the Balor. So the legendary weapon that is needed to kill it was lost. Game over right? Wrong. The Fateless One pins down the Balor with its own Fate, then recreates the legendary spear using Fate itself and hurls it right into the Balor's eye.
Finishing off Templar Octienne, especially if you've gotten tired of the gnomes' yammering on and on about how they're paragons of reason. What do you do to him after along chase on Adessa's winding scaffolds and fighting off his hired assassins? You slam him on the ground so hard he bounces up, and then the Fateless One uses Fate to bat him through a stained-glass window, where the Templar you had allied with is waiting to arrest what remains of him.
Fomorous Hugues at the Well of Souls. A half-pint scientist is the last person you'd expect to drop a Tuatha soldier, but he succeeds and draws the rest away from the Fateless One. It's easy to cheer the guy on and insistently believe he'll survive despite Agarth's predictions. And simply by meeting you, he does!