Not only defeating, but utterly destroyingRandy Orton to win his first World Heavyweight Championship.
On an episode of Smackdown,Three Six Mafia played Henry out to the ring, and he proceeded to go out and utterly destroy Chris Benoit.
Forcing Batista to vacate the title due to the injuries he inflicted on him.
Retaining the title against Randy Orton at Hell in A Cell '11 by kicking out of the RKO, then proceeding to counter Orton's running punt with a World's Strongest Slam for the pin.
He threw John Morrison in the air and caught him as if he was a football. TWICE!!
Once upon a time, Big Show was leaning against a steel cage - only for Mark Henry to break the cage and have Show toppling over via an avalanche clothesline.
He superplexed The Big Show off the top rope, which caused the ring to implode at the Vengeance PPV!
Outside of wrestling, he is one of the only men (and disputedly THE only man) to date to clean and fully press the infamous Thomas Inch Dumbbell single-handedly, bolstering a legit-claim to his nickname.
His commentary during the Bryan/Big Show title match on the 1/6/12 Smackdown. Whenever a heel commentates during a match, Michael Cole typically gets very sycophantic towards them. During the match, Cole tries sucking up and attempts to bait him with a joke about "Bryan vs. Hornswoggle". Henry smacks down Cole's disrespectful commentary, and even tells him to shut up. By effect, this probably also makes this the best Daniel Bryan match commentary-wise, by virtue of the excessive burying him being toned down and Henry even putting over Bryan in the process.