Munchkin/YMMV

Crowning Moment of Awesome: Some of the Bad Stuff is brilliant.
- Ogre: Oh, you are SO dead.
- Plasmoid: It burns you to a tiny, dry, black, ashy, flaky, dead crisp. Then it steps on you. Then it laughs.
  - The Spanish translation is even funnier: it cites more than 25 synonyms for burning. Trying to read them all aloud to your friends is really good for a laugh.
- Goldfish: Nothing happens, but all the other players get to laugh at you mercilessly.
- Itsy Bitsy Spider: The Itsy Bitsy Spider gives you an itsy bitsy bite AND YOU DIE.
- Great Cthulhu: Not only do you die, but all the other players go up a level, just to mock you.
Crowning Moment of Funny: most of the above, and a few other things too.
- "Sex Change" curse, anyone?
* Demonic Spiders: Anything that prevents you from using your hard-~~looted~~earned equipment against it. This becomes really bad when someone notes that you're just winning and sends over Squidzilla to say hello.
Game Breaker: In the original Munchkin, a thief with some good luck (or some Loaded Die cards) could quickly become the most powerful player in the game. The Kneepads of Allure -- which the thief can steal for their own use -- allow you to force somebody to help you with no actual reward, making you as powerful as yourself and the next most powerful player in the game. Both of these are countered by the rest of the players pretty much joining forces to rob you of your powers.
- Technically, nothing in the game is really a game breaker since the whole point of the game is to win by being a Munchkin.
It's Popular, Now It Sucks: The online games site Board Game Geek.com collectively dislikes Munchkin, in part because of some justified rules concerns, but also because of its success.
Hilarious in Hindsight: The guy on the Fez of Fazooli card (in the lower left corner) in Munchkin Cthulhu looks exactly like the Doctor in The Big Bang, bow tie, fez, tweed jacket and all, with the game being years older than the episode. Stupid Timey-Wimey Ball.
Manipulative Bastard: The best players are always these. Examples of Munchkin bastardry include: "protection rackets" in which a player prevents another player from being able to fight a monster, then offers to sell them defensive cards for a high price; lying to newbies about what their cards do/are worth; and asking a player to help you gang up on another, only to backstab them later.