Mushishi/Tear Jerker

The second episode. It's the story of a little girl, Sui, who has a strange and apparently incurable disease in her eyes. The sunlight hurt hers to the point his family locks her in a warehouse with no windows. Biki, her friend, who visits her everyday, brings her food, and plays with her, says: "Maybe they made it for her sake, but it looked like they were abandoning her.".
- One day, Sui tells Biki that she already knows the cause of her disease, there are Mushis, mysterious beings and the focus of the series, living in her eyes. She also tells him that when she closes her "second eyelids", she can see a light river. When she tries to get closer to the river, a mysterious man tells him to not to. Meanwhile, Biki's mother is worried because nobody knows if the disease is contagious, and Biki spends a lot of time with Sui. Then Biki catches the same illness as Sui. His mother brings Sui food instead of Biki the next day:

Sui: Biki? Biki? What's wrong?
Biki's mother: Biki is... I'm not going to let him come here ever again. Your disease has infected him. It's not your fault. It's our fault for feeling pity of another person.

- While Biki's mother ends talking, the light of the light river shines around Sui. She gets too close and she is sinking while repeating "Biki... Biki... I'm sorry... I'm sorry".
Episode 8, especially where the man finally has proof that his wife is dead. All while one of the saddest tunes in the series plays.
The final chapter, where the young, human mountain-master gives up her life to save Ginko. At the same time she's returned to the life stream, her older brother (who never gave up on her even though she was a weird kid and then went missing for over ten years) hears the sound of bells all over the mountain -- the same bells he heard when she was conceived, and knows that she's no longer among the living.