Noticeable Nipples

"My nipples look like Milk Duds!"

—Wimp Lo, Kung Pow! Enter the Fist

Some guys have a tendency to redefine a shot's focal point once the shirts come off.

Not to be confused with Nipple-and-Dimed, which is the Peek a Boo for women's nipples.

Examples of Noticeable Nipples include:

Film

Wimp Lo: "Take a look around... because I rule, baby!"
Chosen One: "And who do you rule? The large, dark-nippled people?"

The widely-reviled Batman costume from Batman and Robin.
- Which also appeared in Batman Forever. And let's not forget Robin's costume also has them (as does Batgirl's, but so subtle as to be easily missed).
Ozymandias has them in Watchmen, as a parody of the Batsuit mentioned above, though they're not nearly as noticeable (and make more sense with his Greek-statue aesthetic).
- The second Silk Spectre's latex costume has molded nipples too. What makes this Noticeable Nipples and not Nipple-and-Dimed is the fact that they're not actually the actress's -- they're little knobs on her costume.
Mark Linn-Baker (Larry of Perfect Strangers fame) did an obscure, forgettable movie called Bare Essentials, where he spent most of his time shirtless on a desert island. One nipple was hairy and one nipple was not. It was fairly distracting.
A couple of Bruce Lee films had occasions of nipple focus. This usually had to do with a character being Japanese; there's some odd Chinese stereotype about Japanese people having different nipples.

Mr. Eko and Sawyer on Lost. And although he almost never appears without a shirt on, John Locke's nipples are almost always noticeable under his T-shirt.
Gary Thorpe from What I Like About You spent almost an entire episode entirely shirtless for some reason. Everyone is Distracted by the Sexy. At one point, another man is trying to have a conversation with Gary and stops mid-sentence to say something about his nipples to the effect of, "--and those things are really just right out there."
On Community, the Walking Shirtless Scene Vaughn is referred to as both "Tiny Nipples" and "Micronipples".
Jeff's Suspiciously Similar Substitute, Oliver, from Coupling had this problem, when he discovered after a long drought that his nipples had "activated" and were constantly, noticeably hard, even through his shirt.
There is an absolutely fantastic instance of this in Glee when Sam Evans joins the swim team. The coach (played by NeNe Leakes from Real Housewives of Atlanta) before letting him join rattles off a pretty impressive speech that seems to serve only to point out his major physical flaws. "Sam Evans, you are one weird-looking kid. I have never seen lips like that on a white boy. And one of your nipples is higher than the other. You must have had to overcome a lot with them crooked nipples."

Orest from Hate Song (pictured).
The nipples in this Amazing Super Powers strip attracted so much attention that they've become their own character: Nip Jones!

King Hippo from Captain N: The Game Master had nipples almost the size of his head.
Family Guy had a cutaway gag in which Uncle Sam was shirtless and had abnormally large areola, grossing other people out.