Shameless/Tear Jerker

In the American series:

Fiona breaking down crying as she yells at Monica for leaving them.
Karen and the other teenage women being forced/pressured into the "purity confessions" and being told that they have to "repent" for being sexually active, particularly the one who only participated in a sexual act under threat of being assaulted with a pipe, but is still told that she has sinned.
- And as an extension of this, Eddie's suicide is this as well. Yes, he could quite frankly be considered a Complete Monster for his treatment of his daughter, but when he realized that Frank wasn't really having sex with her willingly, he considered why his daughter would be doing that to get back at him and in turn realized how much of a horrible person he'd been, and due to his moral absolutism, he took his own life out of guilt.
Surprisingly enough, Frank breaking down and crying, and even going back to Monica after his mother's death.
Fiona's discovery that Monica and Frank stole all of her savings is just...heartbreaking.
- Fiona's tantrum at the end of A Great Cause is one of the most beautifully tragic moments on television. After Fiona sees all the repercussions for trusting Monica with her responsibilities and trying to have a life of her own, she has a short but epic tantrum in the kitchen. She stops herself and then she goes right back into routine, being the mother her own could never be.
Fiona shouting at Monica to wake up when she refuses to get out of bed for days during a low swing. Made worse when Debs and Ian try to bring her food, but she refuses it. Made even worse when Monica tries to commit suicide during Thanksgiving dinner.
When Lip finds out Karen's baby isn't his.
The immensely melancholy opening scenes of the second season finale.
The fact that Monica had an opportunity to receive therapy and recover from all of the crazy, and it was destroyed because of Frank's selfishness.
Karen abandoning Sheila.