The Binding of Isaac/Characters

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A list of characters who appear in The Binding of Isaac. Currently under construction, please contribute!

Isaac/Other Playable Characters

A little boy who gets thrown in the basement by his mother and has to fight for his life. Variations with different stats and starting items can be unlocked by gaining various achievements.

Shared Tropes

Isaac

Isaac without any special accessories. The only character playable from the start. After beating It Lives with ??? Isaac starts with the D6: an activated item capable of transmuting any collection related item(s) into other random item(s).


Magdalene

Isaac with a blonde wig and a red bow. Maggy starts with the Yum Heart: an activated item that restores one heart upon use.


Cain

Isaac with an eye patch. Starts the game with the Luck Foot: a passive item that improves random events in various ways.


Eve

Isaac with a wig and eye shadow. Starts with The Whore of Babylon and the Dead Bird.


Judas

Isaac with a fez. He starts the game with the Book of Belial, an activated item that increases attack power for one room.


  • Glass Cannon: More so then Cain. Starts with average rate of fire, range, speed and high attack power, further bolstered by his Book of Belial. In exchange, he starts with only 1 heart.
  • Nice Hat

Samson

Isaac with long brown-hair and Big Ol' Eyebrows. He also starts with a red headband called Blood Lust, which grants him a temporary (last a whole room) but substantial attack-power boost for each enemy he kills. Introduced in Wrath of the Lamb.


  • Badass Long Hair
  • Blood Knight: His trademark power-up is called Blood Lust, after all!
  • Conservation of Ninjutsu: Invoked Trope by his special hair-band. The more enemies you face in a room, the more powerful you'll get! But single target rooms won't trigger any attack-boost.
  • Glass Cannon: With just 1 starting heart container, he's as fragile as (and under some circumstances, even more than) Judas. However, his special gear makes him extremely effective against large groups of enemies and/or mook makers.
  • Hachimaki

???

A shout-out to Edmund McMillen's Newgrounds account (specifically his "Dead Baby Dressup" game). Starts with The Poop, which creates a pile of dung once per room.

Possibly Isaac who decided to hide/went to in golden chest and suffocated there.

Enemies

Flies

Black Fly/Red Fly/Moter

Boom Fly/Red Boom Fly

Puster

Sucker

Humanoid

Gaper/Pacer/Gusher/Horfs

Hopper/Fire Hopper/Leaper

Maws/Mr. Maw

Mulligan/Hive

Globin

  • Elite Mooks: has a second variety which are faster, have more health, and (unlike Gapers) has 1 eye. As well when they are turned into a meat pile they try to run away from the player until reforming.

Knights

  • Attack Its Weak Point: The front of them is solid bone or petrified flesh. The only way to actually damage it is to hit it in the back of its head, the exposed brain.
  • Elite Mooks: Its second variety chases the player instead of wandering aimless. They have a crying Isaac face instead of a brain on their back.

Vis

Baby

Dople

  • Elite Mooks: Instead of looking like a meat puppet. It looks like a demon that can: fly, shoot a three spread and do more damage. Good things is that its bullets travel slower giving you time to dodge and shoot.
  • Enemy Without: They mirror the player's movements, including shooting, but most rooms come with a mechanism with which to destroy them. There are also bombs, and praying that whipped shots will work.

Fred

Lump

Maggots

Charger

Maggot

Spity

Spiders

Added with Wrath of the Lamb. A faster alternative to the flies, though they're land-bound.

Other

Clot

Clotty

Host

  • Attack Its Weak Point: Only in the grey variation. To hit them you must wait for it to expose the flesh under the skull.
  • The Cameo: From a multiplayer player flash game with the same name.
  • Won't Work On Me: Grey Hosts are protected by their skull when they aren't firing. Trying to hit them does nothing. Trying to bomb them just annoys them.

Brain and MemBrain/Mom Brain

Guts

Pokies

Sentry

Boil

  • Elite Mooks: As of Wrath of the Lamb there is a second version which shoots green bombs, much like Sloth. As well as mobile versions of each.
  • Mook Maker: There's also a version made of spider silk, which spits out spiders.

Eye

Leech

  • Elite Mooks: A second version that has an eyeball and explodes when killed.
    • Palette Swap: There's an alternate version of that that's angelic white. Not just tinted that way either, but a separate enemy.

Para-Bite

Bosses

The Basement/The Cellar

Monstro

The Duke of Flies

Gemini/Steven

  • Bullfight Boss: The big one can tire out after a few moments of running. If the big is killed first then the small will turn red, give chase and never tire out.
  • The Cameo/Mythology Gag: Steven is from Time Fcuk.
  • Dual Boss: One big version that charges the player and one small version that shoots bullets.
  • Turns Red: Again, what the small one does when the big one dies.

Larry Jr.

Widow

Pin

  • Degraded Boss: Odd variation: Pin is introduced in the new expansion as a weaker version of Scolex. Despite this, it's still a boss in its own right.
  • Tactical Suicide Boss: Is not immune to it's green exploding projectiles, and due to a quirk in hit detection can actually damage itself with them when it begins to bury underground.

The Caves/The Catacombs

Fistula

Gurdy

Peep

  • Eye Scream: It detaches its eyeballs when its HP starts getting low. They block your shots and will inflict Collision Damage on you if you touch them... Oh! And they're indestructible until you kill their original owner.
  • Meaningful Name:
    • Pronounce the second p as though you were saying the letter "p".
    • There's also the fact that "peep" can mean to look at something, and he attacks you with his eyes.
  • Toilet Humor: Attacks with urine.

Chub/C.H.A.D

Blighted Ovum

  • Back from the Dead: Gemini is now a zombie, and is accompanied by his conjoined brother's ghost. The image appears to be more of a sperm and an egg. That wouldn't discredit this trope, it would just be a different set that came back, because at least the large one is undeniably dead no matter what perspective you look at it from.

The Hollow

Queen of Carrion

The Husk

The Depths/Necropolis

Loki

Monstro II

Gish

Mask of Infamy

  • Attack Its Weak Point: The mask is invincible until you destroy it's heart. Even after that, you need to hit it from behind.
  • King Mook: A beefed-up version of a standard enemy also added in Wrath of the Lamb.
  • Shout-Out: Inspired by Carmillia's mask in Castlevania.

Daddy Long Legs/Triachnid

  • Ascended Glitch: It is hinted that a future update will reflect this glitch somehow.
  • The Cameo/Mythology Gag: The alternate is a reference another one to another of Edmund's games. Namely, Triachnid.
  • Dummied Out: As hinted here, there was an alternate version this boss that was cut before the game was released. It wasn't removed entirely, however. Due to a glitch, it originally would replace the Cathedral's True Final Boss. This was eventually corrected.
  • King Mook: A giant spider, same as Widow.

Mom

Isaac's mother. In a fit rage/insanity/devoutness/whatever you think it is, she attempted to take up a knife against Isaac and forced him to flee to the basement to live.



The Womb/Utero

Scolex

  • Attack Its Weak Point: You can only damage it by hitting it in the very back segment.
  • Fragile Speedster: It has the lowest health of any boss in the game, but it makes up for this with its speed and hard to hit weakness.

Blastocyst

The Bloat

Teratoma

Lokii

Mom's Heart/It Lives


Sheol

Satan

The Cathedral

Isaac


???

As of version 1.15, Blue Baby replaces Isaac after Isaac is defeated when a character is holding the Polaroid.


The Seven Deadly Sins

Envy/Super Envy

Gluttony/Super Gluttony

Greed/Super Greed

Lust/Super Lust

Pride/Super Pride

Sloth/Super Sloth

Wrath/Super Wrath

Harbingers

Famine

Pestilence

War

Death

Headless Horseman

  • Degraded Boss: In later stages. Usually found as two or three copies of its head in the same room.
  • Dual Boss: The boss is split into: his head, that charges and shoots small bullets, and his body, which shoots large bombs and leaves trails of blood.
  • Headless Horseman: Well, yeah.

Conquest

Other

The Fallen

Krampus

The Wretched

  1. Pills will never have negative effects, Rewarding Vandalism is more likely to happen, the odds of winning the Skull game increases from one-third to one-half, and gold chests are more likely to give items (as opposed to pickups).