Will & Grace/Tear Jerker

Within the last few minutes of the last ever episode, Jack and Karen sing 'Unforgettable' to the piano after realising that through all their boyfriends and husbands, they still had each other.
The episode when Grace marries Leo. Oh, so many moments.
- Will's final words, after he lifts Grace's veil.

Will: [to Leo] Take good care of her...okay?

- - It becomes even more of a tearjerker when you know that the marriage would fall apart just a few years later--after Leo admitted to Will that he had cheated on Grace.
There was a room in Karen's house which she adamantly refused to show to Jack. When Jack finally breaks in, it is shown to be a nursery from a pregnancy scare Karen had about a season or two back. Karen, in her usual manner, casually remarks how she'll turn it into a wine cellar or something before they leave. With Jack safely in the hall, Karen looks back at the nursery with the most heart-wrenching expression on her face, and shuts the door.
In one episode, Jack asks Will if he's ever considered a relationship with him. He asks it in typical Jack-style, and when Will laughingly tells him "no", appears to laugh it off in typical Jack-style--except for the split second that we see the genuine hurt on his face.

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