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A plot wherein the characters are affected by a force unknown to them and become increasingly snappish and disagreeable to each other, sometimes escalating to outright murderousness. This is often a subtle plan by the [[Villain]] of the show who figures it's easier to let the heroes kill off each other. Naturally, the heroes realize it just in time. This is sometimes a way for characters to vent hitherto unmentioned grievances. Ironically, despite the use of [[Applied Phlebotinum]], this is a more believable version of [[Toilet Seat Divorce]] and [[Conflict Ball]], since everyone is [[Not Himself]].
 
The [[Trope Namer]] is the plot of the ''[[Transformers Generation 1]]'' cartoon storyline "The Return of Optimus Prime", a red glowy virus transmitted by touch that affects human and robot alike. Contrast with [[Love Is in Thethe Air]]. Subtrope of [[Emotion Bomb]]. See also [[Mind Virus]] and [[Artifact of Attraction]]. In video games with [[Standard Status Effects]], this can show up as an actual game mechanic, usually "Confusion" or "Berserk."
 
{{examples}}
 
== Anime and Manga ==
* ''[[Higurashi no Naku Koro Ni (Visual Novel)|Higurashi no Naku Koro Nini]]'' arguably [[Deconstructed Trope|deconstructs]] this trope {{spoiler|since the main characters always suffer from it. Through most of the arcs, no one figures it out, and as a result, anywhere from more than half of to the entire cast winds up dead at the various ends}}.
** ''[[Higurashi no Naku Koro Ni Kai]]'' turns it straight again when {{spoiler|the heroes learn about the plague in question and conquer it with [[The Power of Trust]].}}
** Further, one character does have it figured out in every arc (and a few more know about it but don't find out about specific instances until too late). {{spoiler|Unfortunately, by not fighting against it aggressively enough she produces the same effect as if she hadn't known about it at all, which is to say none, and still gets to watch her friends descend into violent madness.}}
** It's actually more of a {{spoiler|Paranoia}} Plague than a [[Hate Plague]], with a side order of {{spoiler|hallucination}}, but it gets the job done.
* In ''[[Read or Die (Anime)|Read or Die]] The Television Series'', one [[Villain of the Week]] uses two kinds of sounds to protect his base as the heroines try to infiltrate it, both of them out of the range of normal hearing: one is a subsonic hum that enhances depression and melancholy in people who are already disposed to it, and the other is a supersonic hum that makes more excitable people angrier and more irritable.
* Yubel uses this in duels to great effect in ''[[Yu-Gi-Oh GX|Yu-Gi-Oh! GX]]''. While she's on the field as a monster, she can force monsters to attack her; she takes no battle damage, and inflicts the same damage to her opponent in retribution. She calls this effect "Nightmare Pain." Shortly after Yubel reveals herself in Season 3, Judai's cloest friends are also infected with a Hate Plague against him, which was quite effective in bringing out his [[Super-Powered Evil Side]], especially when followed by their apparent deaths.
* In the first Star Trek manga, a man and a woman who were once lovers (and who had a bit of a falling out) come on board the ship. They end up making all the men and women on board turn against each other merely from their presence.
 
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== Comics ==
* Also ''[[Transformers]]''-related, one issue of Marvel's ''Generation2'' comics featured black energy goo beings that induced and lived on other creatures' aggression.
* [[Inverted]] in the ''[[Hellblazer (Comic Book)|Hellblazer]]'' arc "The Red Right Hand", in which the plague makes its victims incredibly empathic. Unfortunately it takes hold in [[Violent Glaswegian|Glasgow]] and so everyone begins to share one another's guilt and misery, culminating in mass suicides.
* An alternate version of the ''New [[X -Men]]'', set in the House of M universe, dealt with Wallflower, a mutant with pheromone powers, causing Sooraya to engulf her best friend Jubilee in a sandstorm that likely would have shredded her body to its bones if given time.
* In ''[[The Savage Dragon]]'' #55, a massively powerful mind-controller [[Power Incontinence|unintentionally]] sends everyone in Chicago into a murderous rage the moment he steps out of his bunker.
* In a ''[[Star Trek: theThe Original Series (TV)|Star Trek the Original Series]]'' comic a long time ago (it came with a vinyl record to read along with) wherein an alien [[Catgirl]]'s pet, a Waul, gets loose on the Enterprise. It's agitated yowling makes everyone on the crew start sniping at each other, and the closer they got to the critter the worse it got. Once it was reunited with its mistress, it was happy and purring again.
* During the [[Blackest Night]], [[Emotion Eater|Psycho-Pirate]] used these on Smallville. [[Nightmare Fuel]] ensued as his mask's abilities to influence any nearby target to near-suicidal hatred, uncontrollable fear or demented avarice ensued, heightening minor feelings to killing urges.
* The main shtick of the villain Hate-Monger from the [[Marvel Universe]]. (Who is actually [[Adolf Hitler]]. )
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* ''Les Schtroumpfs Noirs'' (The Black [[The Smurfs|Smurfs]]), the first Smurf comic book story, involved a Smurf being bit by a blackfly. As a result of the bite, the Smurf turned solid black and became insane, spreading the plague by biting his fellow Smurfs' tails. Fortunately Papa Smurf was able to cure the plague before it was too late. This story was made into an episode of the Smurfs cartoon, although in the cartoon, the evil Smurfs were [[Bowdlerise|purple, not black]].
* In ''[[Astro City]]'', when Black Velvet is mortally wounded by Jitterjack, her body releases black energy that infects the populace and starts a riot.
* In the earlier ''[[Sonic the Hedgehog (Comic Bookcomics)|Sonic the Hedgehog]]'' comics, evil wizard Ixis Naugus can amplify peoples' emotions. This is hinted to be the driving point for the Great War between the Mobians and human-esque Overlanders, and then the Mobian/Robian civil war.
** More recently, he used that same magic on the citizens of New Mobotropolis, magnifying their mistrust of NICOLE - following her stint being [[Brainwashed and Crazy|brainwashed]] by the Iron Dominion - into full-blown paranoia, so that they will view her as a threat, and him as their "[[Dark Messiah|savior]]".
* The plot of ''[[Crossed (Comic Book)|Crossed]]'' is centered on a virus that causes its victims to turn into predatory psychopaths.
* In ''[[Darkwing Duck (Comic Bookcomics)|Darkwing Duck]]'', the Phantom Blot has created an inky mind-altering substance to create new rogues in St. Canard which is also used to control the populace briefly.
 
 
== Films -- Live-Action ==
* ''[[Twenty Eight Days Later|28 Days Later]]'' and its sequel revolve around a [[Technically Living Zombie|sort of]] [[Zombie Apocalypse]] caused by a literal Hate [[The Plague|Plague]], the Rage Virus.
** Ditto ''[[The Crazies]]'' and ''[[REC]]''. ''[[The Crazies]]'' is a somewhat different variant, as the infected often retain coherence and elements of their personality, unlike the mindless fury of the ''28'' movies and ''[[REC]]''.
* In the movie Return in Red, a government agency uses sound waves to induce insanity and homicidal urges in the people of a small town.
* In the movie ''[[Ghostbusters]] II'', the sewers of New York City become filled with an ectoplasmic sludge that absorbs emotions. The Ghostbusters discover it while it's been negatively charged, and after they end up covered in it, they briefly end up going at each other's throats. Egon discovers the malleable nature of the slime, however, and in order to break through a barrier of negatively-charged slime, the Ghostbusters positively charge some of it through [[Crowning Moment of Awesome|a combination of the song "Higher and Higher", and the most inspiring thing they can find in Manhattan: The Statue of Liberty.]]
* One of the "non-lethal" weapons employed by the good guys at the end of ''[[Mystery Men]]'' is a ray (the Blame Thrower) that can cause angry arguments amongst whomever gets hit with it. A rare case of the protagonists employing such a tactic as psychological warfare.
* ''[[Serenity (Film)|Serenity]]'': The Reavers (murdering, raping madmen who terrorize the fringes of the <s>universe</s> small star cluster/ solar system) are revealed to be {{spoiler|the victims of a government-sponsored lotus-drug gone so bad. It was meant to weed out aggression in the population. Instead it made the majority of the population so passive that they couldn't even be bothered to take basic measures to continue living, while it became a Hate Plague for a fraction of a percent of the population. They proceeded to wipe out whoever was left, and then start ''recruiting''.}}
* This is the alien threat in the film ''[[Alien Cargo (Film)|Alien Cargo]]''.
* Utilized by Loki through his scepter in ''[[The Avengers (Filmfilm)|The Avengers]]'' to make the already volatile team turn on each other so as to distract them from his assault and unleash the [[The Incredible Hulk|Hulk]] upon S.H.I.E.L.D.'s helicarrier.
 
 
== Literature ==
* The Cunning Man from ''[[Discworld (Literature)/I Shall Wear Midnight|I Shall Wear Midnight]]'' is an ''embodiment'' of this. He's the ghost of a witch hunter whose hatred for witches is so great, wherever he goes people become more suspicious and angry with witches.
* In David Moody's ''[[Hater]]'' and its sequel ''[[Dog Blood]]'', a virus causes people to murder their loved ones and anyone else in their path. The local media even calls the infected people "haters."
* Played with in ''[[Star Trek a Time To]]''. It sort of happens on the planet Delta Sigma IV, in ''A Time to Love'' and ''A Time to Hate'', only with a twist. {{spoiler|The plague isn't really causing the hate and violence- in fact, it's curing the populace of a mind-altering drug that kept them peaceful. Suddenly confronting emotions such as hate and rage for the first time, the Delta Sigma inhabitants can't cope, and old racial tensions erupt into violence. Riots soon spread across the planet.}}
* Used in [[David Eddings]]' ''[[The Elenium|Elenium]]'' arc--the negative influence of the [[MacGuffin]] / [[Sealed Evil in Aa Can]], the Bhelliom, causes the heroic [[Five-Man Band]] to start getting mutinous...
** The Bhelliom got far nicer in the ''Tamuli'', though.
* ''[[Harry Potter]]'', in ''Deathly Hallows'' {{spoiler|the Slytherin Locket Horcrux has this effect and leads to Ron leaving the group for a while}}.
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* ''[[Able Team|Able Team #8: Army of Devils]]''. A drug capable of creating instant rage in the user is smuggled into Los Angeles, in an attempt to create a race war in the United States.
* One of the ''[[Dinotopia]]'' companion novels (''The Maze'') includes a heavier-than-air [[Hate Plague]]-inducing gas as one of the obstacles en route to the center of the titular maze. {{spoiler|The raptor of the trio is driven out of the group first and decides to go up the walls, clearing his head. He then manages to take advantage of the gas' effects to dare the other two to stay together and not kill each other until they get out of the hazard zone.}}
* In ''[[The Wheel of Time (Literature)|The Wheel of Time]]'', the dagger from Shadar Logoth is so tainted with evil that his carrier becomes paranoid and hateful, and then starts to infect other people.
** Padan Fain, a recurring villain partially possessed by the spirit who ''created'' Shadar Logoth, also has this effect- people who spend too much time in his company become increasingly paranoid, ill-tempered, and generally corrupt. When he gets the dagger back (another character carries it for a good chunk of the early books) his powers are increased dramatically.
* Kyr Bulychev's book ''The Purple Sphere'' is about an artificial virus (stored in the titular container) which causes unnatural hatred in anyone infected. The developers got infected. They killed each other off, the rest of their planet's biosphere evolved into a [[Death World]].
* [[James Herberts the Fog]] is about the titular mist--it's [[Sealed Evil in Aa Can|a bio-weapon]] that turns half of England insane and depraved in a manner very reminiscent of ''[[The Crazies]]''.
** ''The Dark'' by the same author uses a more supernatural version of the same trope, with similar results.
* The god of war Ares in [[Percy Jackson and The Olympians]] radiates an aura that makes people around him more susceptible to violent impulses. It's not quite a weapon, but it means the characters have to be more careful around him since he is always looking for an excuse to start a fight.
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== Live-Action TV ==
* ''[[Star Trek: theThe Original Series]]'', "Day of the Dove": An [[Energy Beings]] that feeds on hate brings the Federation and the Klingons, who are trying to abide by the peace treaty, into conflict. It goes as far as implanting [[False Memories]] so that the manipulated will have an extra source of conflict. An interesting part of this trope in Star Trek is that those who are killed are somehow brought back to life with their fatal wounds healed to fight again. Once they all figure it out the creature is repelled from the ship by laughter. Lots and lots of laughter.
** In "The Tholian Web," a [[Negative Space Wedgie]] drove the crew of one starship to kill each other, and then begins to drive the Enterprise crew to outbursts of anger.
** In "This Side Of Paradise", an anger-inducing sonic broadcast is used to counteract the effects of tranquility-inducing spores.
* ''[[Star Trek: theThe Next Generation]]'' also had such an episode, which was caused by an aging Vulcan telepathically "leaking" his suppressed emotions into the minds of the crew. {{spoiler|Said aged Vulcan is ''Spock's father,'' and he has, basically, Vulcan Alzheimer's Disease. Picard puts his mind at risk by letting him "absorb" some of his willpower because if anyone finds out, the treaty Spock's dad has been working on ''for years, if not decades'' could be at risk. By the by, the effects on Picard really gave his actor, Patrick Stewart, a chance to ''shine''.}}
* ''[[Star Trek: Enterprise]]'' had an episode where the closer the ship got to an undetected [[Negative Space Wedgie|singularity]], the more the crew started to freak out, basically giving them a nuclear version of [[Super OCD]].
** This is also one of the possible effects of [[Green-Skinned Space Babe|Orion]] pheromones on other women.
* ''[[Crusade]]'', the sequel to ''[[Babylon 5]]'', had an episode where the crew visited a planet that was boobytrapped with a means of driving visitors into murderous rages.
** It was much more devious. The people would not only perform violent acts. Afterwards, they would have no memory of the event and instead remember seeing a shadowy figure performing the act. Of course, it wasn't really a plague but {{spoiler|Technomage nanites}}.
* The Croatoan virus from ''[[Supernatural (TV series)|Supernatural]]'', which was later part of [[Horsemen of the Apocalypse|Pestilence]]'s plan to release it nationwide as part of [[Satan|Lucifer's]] endgame.
* Not quite a hate plague but a spiritual sister to the trope would be the depression toxin from the ''[[Red Dwarf (TV)|Red Dwarf]]'' episode "Back To Reality".
* Used for humorous effect in the "Syzygy" episode of ''[[The X -Files]]'', in which a rare planetary alignment causes strange behavior in a small town, and even Mulder and Scully begin to snipe at each other.
** More serious versions appear in "Ice" in which an extraterrestrial parasite causes an Arctic research team, and later the investigating team, to turn on each other by increasing their paranoia; and in "Red Museum" as part of a [[Government Conspiracy]] the children of a town are infected with alien DNA which causes an increase in violent behaviour.
* ''[[Angel (TV)|Angel]]'' had a variant: the touch of a particular vicious misogynist caused any man he touched to hate and attack any woman they came near.
** In another episode, the bizarreness of the week causes people to bleed from their eyes and go into a murderous rage about whatever they feel.
* One episode of ''[[The 4400]]'' concerned an attack by a 4400 who was able to stimulate aggression in men, resulting in a breakdown of discipline at NTAC headquarters.
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* An early episode of ''[[Stargate SG-1]]'' subjected the team to hypersonic frequencies that made some of them very irritable, resulting in a shouting match and a delightfully awkward non-apology apology afterward.
** A minor one was caused by withdrawal symptoms from some creepy Goa'uld light in the episode with the same name. Similarly, Daniel's withdrawal from the sarcophagus in ''Need'' had him almost shooting Jack in one scene.
* ''[[The Sarah Jane Adventures (TV)|The Sarah Jane Adventures]]'' had a single-target variation, where anyone who heard or read the name "Clyde Langer" turned against Clyde.
* An episode ('Sense and Antisense") of ''[[Millennium (TV series)|Millennium]]'' (the TV series produced by Chris Carter) has Frank Black tracking down a man supposedly infected by a hate virus. At the end we see a photograph of the man posing with military personnel marked "Kigali, Rwanda, 1994".
* An episode of ''[[The Man From UNCLE|The Man from U.N.C.L.E.]]'' ('The Suburbia Affair') centered around a plot like this-- the electric lights in a suburban neighborhood vibrated on a frequency that caused the people living there, including our undercover heroes, to become irritable, suffer headaches, and fight amongst themselves. A mob scene was narrowly averted at the town meeting.
* The ''[[Farscape (TV)|Farscape]]'' episode "Crackers Don't Matter" has a highly amusing Hate Plague, causing several characters to become obsessed with ensuring their fair share of crackers, to the point of barricades and gun battles.
* One of the Gelliant Gutfright sketches from ''[[A Bit of Fry and Laurie]]'' features the "Fighting Buttercup," a flower which causes anger and aggression {{spoiler|for about five minutes. And then explodes.}}
* ''[[Eureka]]'' - "All the Rage": A device designed to ''calm people down'' [[Gone Horribly Wrong|instead]] turns GD into [[Shout-Out|"a Romero]] [[Night of the Living Dead|movie"]].
* ''[[Ultra Seven]]'' episode 8 had aliens lace cigarettes with a toxic seed that made humans violent. It was all a plan to repopulate the Earth after humans wiped each other out.
* In ''[[Alphas]]'', one of the [[Villains Of The Week]] Matthew Hurly has the ability to release pheromones that causes the people around him explode in homicidal rage.
* The "Hound of Baskerville", in the ''[[Sherlock (TV)|Sherlock]]'' episode of that name, turns out to have been a hallucinogenic drug that also functioned as this, giving those it was forced upon images of horrible monsters... and then making them want to murder them.
 
 
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* Dracorage in ''[[Forgotten Realms]]'' was murderous madness periodically magically induced in dragons world-wide. Designed by ancient elves to break dragons' control over the world, later magical device was hijacked and used {{spoiler|by Sammaster to convince evil dragons that becoming [[Undead]] with his help is their only option to avoid insanity and then ignominious death.}}
* Mindflayers are given magical stones that could potentially have this result in the [[Dungeons and Dragons|D&D]] 3.5 supplement ''Lords of Madness''.
* ''[[Promethean: The Created (Tabletop Game)|Promethean: The Created]]'' has Disquiet, an instinctual reaction by ''all'' living things towards the titular creatures that makes them gradually desire to destroy them-even if that isn't normally in a person's nature (several times, the book features humans going into [[Humans Are Bastards|jerk-mode]] towards Prometheans, [[My God, What Have I Done?|then wondering exactly why they were doing that a moment later]]). Is it any wonder that a Prommie's quest [[To Become Human]] [[Blessed Withwith Suck|makes perfect sense]]?<br /><br />There are two things that don't instinctively hate Prometheans -- Vampires and Werewolves. Instead, they find Prometheans so unsettling that it actually becomes harder for them to resist their [[Unstoppable Rage]] -- meaning that they'll quite likely end up killing the Promethean anyway, along with any other allies or innocents that are unfortunate enough to be there at the time.
* One of the horrors described in the ''[[GURPS]]'' sourcebook ''Creatures of the Night'' is the Dread Blossom, a flower that makes people exposed to its scent paranoid and xenophobic.
* Wraiths in ''[[Shadowrun]]'' can cause uncontrollable aggression in those near them.
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* In ''Blood Omen: [[Legacy of Kain]]'', the player can generate this effect with the 'Inspire Hate' spell, causing all nearby Mooks to ignore the player and attack each other. The description of the spell specifically states Kain's sadistic amusement with the effect this has on the survivors...
** Kain gains the same ability in ''Defiance''. In both cases it's related to the [[Cosmic Keystone|pillar of conflict]].
* This is the main goal of Dr. Regal in ''[[MegamanMega Man Battle Network]] 5'': Combine the Soul Net (unifying all hearts) with the power of the Dark Chip (makes people evil). We see a little bit of the effects during the cutscene before the [[Final Boss]].
** Gemini Spark's chapter's evil plan in ''[[Mega Man Star Force]]'' is to attach a virtual plus or minus to each person, invariably attaching the same sign to two friends, lovers, spouses, etc. so that they'd argue with each other. The game never explored the effect of two people with opposite signs...
** It's pulled again at the end of the second game. The villain gets away with it for a while, too, and this time without the awkward positive/negative questions.
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* ''[[Resident Evil]]'' has this introduced instead of the zombie plague in all the other games in the form of Las Plagas, which (in their normal form) are only able to make their victims more aggressive, albeit controlled. Experiments show how much [[Body Horror|worse]] this can actually be for its victims.
* In [[Trauma Team]], almost all of the murders solved by Naomi was caused by the murderer being infected with the {{spoiler|Rosalia}} virus.
* In ''[[Bio ShockBioshock]]'', the Enrage plasmid causes splicers to go crazy (well, crazier than usual) and attack anyone-- you, their fellow splicers, or even Big Daddies.
* This happens in ''[[Pokémon Colosseum (Video Game)|Pokémon Colosseum]]'' and its sequel ''Pokémon XD''. Pokemon's hearts are closed, so that they have no sense of compassion, and only their primal bloodlust. They'll attack anything, and they sometimes go into uncontrollable rage fits.
* The Pox of LeChuck in ''[[Tales of Monkey Island]]''.
* The Delphinius Parasite in ''[[Shin Megami Tensei (Franchise)|Shin Megami Tensei]]: [[Strange Journey]]'' is effectively this, though they have difficulty even finding out a physical vector for the disease.
** [[Paranoia Fuel|Because it does]] [[Energy Beings|not have one]].
* Features in ''[[Deadly Premonition]]''. {{spoiler|A purple gas produced from the Red Seeds that drives people into a murderous rage was responsible for the Original Raincoat Killer incident.}}
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== Western Animation ==
* The [[Trope Namer]] is the Hate Plague in ''[[Transformers Generation 1]]''. Also occurred as one of a small handful of [[Shout-Out|Shout Outs]] in ''[[Beast Machines (Animation)|Beast Machines]]''.
** Despite the name, it doesn't really fit. The infected often initially become violent, but will then begin to work together with other infected. In the second of the two-parter that introduced the plague, Cyclonus commands the other Decepticons to retreat after coming under fire from the Autobots, and they follow his orders unquestioningly. It's more of a "Lack of inhibitions" plague than a "hate" plague.
*** One example of the afflicted cooperating are the combiners. In spite of fighting amongst themselves minutes earlier, the Aerialbots re-combine into Superion. They later infect Defensor. Defensor immediately collapses into the 5 Protectobots; the five fight amongst themselves. The same happens when Galvatron raids the lab containing the plague. Menasor and Bruticus are touched immediately by afflicted Autobots and immediately collapse into 10 brawling Transformers.
*** The Decepticons' cooperation could be [[Fridge Brilliance]] at work, as hatred had already been a part of their driving motivation, so wouldn't necessarily alter their behavior as much as it does, the non-villainous characters'. Doubly so for Menasor and the Stunticons, whose bios indicate that they operate on a level that barely makes it ''up'' to [[Teeth-Clenched Teamwork]].
* In ''[[Justice League]]'', supervillain Gorilla Grodd uses his mental abilities to give the team's minor issues with each other a little push, much to their embarrassment.
* Both the [[The Care Bears Movie (Film)|first]] and [[Care Bears Movie IIAII: A New Generation (Film)|second]] ''[[Care Bears]]'' movies show the villains having a dark influence on surrounding people - the kids at the amusement park where Nicholas and the evil book are become rotten little monsters, and so do the kids at the camp where Dark Heart sets up shop.
** One episode of the animated series featured a [[Applied Phlebotinum|mysterious meteorite]] infecting a small town, making the surroundings dull and gray and the citizens depressed and apathetic. [[Nightmare Fuel/Care Bears|Rather creepy,]] [[Fridge Horror|in retrospect,]] when it started affecting the Care Bears as well.
* The [[So Bad It's Good]] ''[[Batfink]]'' program featured main recurring villain Hugo A-Go-Go creating "hoke", a combination of hate and smoke. After it was released, the eponymous hero and his sidekick began arguing, including [[Lampshade Hanging|placing a lampshade]] on the overuse of the hero's "[[Luckily, My Powers Will Protect Me|My wings of steel will protect me]]" catchphrase, with the henchman replying, "Yeah, yeah, why don't you get some new dialogue?"
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** Really hit home when the girls went to see the Professor. Imagine all the love a parent has for their children magically swapped with hate.
* A more family friendly version is see in ''[[Theodore Tugboat]]'', in the debut episode of Guysborough the Garbage barge. His grumpiness gets Theodore in a bad mood, which puts Emily & George in a bad mood and so on until the entire harbour becomes snappy with each other.
* One episode of ''[[Dungeons and Dragons (Animationanimation)|Dungeons and Dragons]]'', featuring the usual "get to the one-chance exit back home" set-up, forced the kids to go through a maze to reach a portal. One part of the maze made all the kids become very aggressive, tetchy and downright bloodthirsty, which almost resulted in a nasty fight. Fortunately, Hank was able to snap everyone out of it.
* The [[My Little Pony]] [[My Little Pony: theThe Movie|movie]] had the Smooze, which, in addition to making everything putrid and covering the land in a thick layer of concrete-like substance, made characters touched by it aggressive, spiteful and pessimistic.
* ''[[My Little Pony: Friendship Is Magic (Animation)|My Little Pony Friendship Is Magic]]'': In [[My Little Pony Friendship Is Magic (Animation)/Recap/S2 E1 The Return of Harmony Part 1|"The Return of Harmony"]], Discord inflicts most of the main characters with the opposite emotions from their respective [[Personality Powers|Elements of Harmony]]. Honest Applejack becomes a liar, merry Pinkie Pie becomes broody, generous Rarity becomes greedy, kind Fluttershy becomes cruel and loyal Rainbow Dash deserts her friends.
* The little pink dog [[Courage the Cowardly Dog|Courage]] once faced a literal sweeping Hate Plague called the "Cruelty Curtain". This energy barrier caused anyone it touched to become ridiculously rude to the point where benevolence was considered a crime. Courage managed to re-wire the Curtain so that it turned people nice--[[Heel Face Turn|even its evil creator]], who was later elected mayor.
 
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