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* In the manga & anime of ''[[Ah! My Goddess]]'', Belldandy gets drunk on cola, and proceeds to wander around town [[Literal Genie|granting wishes]].
* This happens to Usagi twice in ''[[Sailor Moon]]'', in both cases she mixes up alcohol with juice. First in the first season in an episode based directly on a manga chapter she winds up [[Kissing Under the Influence]] [[What the Hell, Hero?|(bad Mamoru!)]]; and a second time in the third (S) where it's actually much funnier. In the second case she goes completely la-la and starts speaking gibberish in both Japanese and English at swanky party, the (English) guests find her delightful.
{{quote| '''Usagi:''' ''(butting into a discussion on the theory of relativity)'' The pudding of relativity? Let's see... Well, in other words, you take milk, eggs and sugar, and stir it all up. Then you put a lid on it, and for about 30 minutes, you steam it... Oh! And if you forget the whipped cream, you're no good as a woman. Yeah.}}
** Even funnier is the fact that the Americans she's speaking to at the party during this play along with it, seeming to be actually interested in this and finding it a new and unique take on the subject before Mamoru escorts her elsewhere.
** What's even more hilarious about these incidents is that Usagi normaly takes no more than a couple of sips of the drink in question. Either that's some strong wine they're having or she's an utter lightweight.
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* In ''[[Hidamari Sketch]]'', Hiro wrongly bought alcoholic juice at Yuno and Miyako's welcoming party, and the two freshmen got drunk. While Miyako is still [[Cloudcuckoolander|herself]], the generally innocent Yuno started ranting about [[It Just Bugs Me|It Just Bugs Me's]]... and Sae uttering an [[Engaging Conversation]] even she [[Ship Tease|was not drunk]]...
* Rock Lee's sake induced drunken kung fu in ''[[Naruto]]''.
* In ''[[Clannad]] ~[[After Story~]]'', after drinking one cup of sake, Nagisa immediately starts acting like a [[Clingy Jealous Girl]] towards Tomoya... in regards to her ''[[Hot Shounen Mom|mother]]''. Then said mother gets drunk too, and starts acting flirtatiously towards Tomoya. Needless to say, Tomoya was not very happy about this situaton.
** Not helped at all by Akio finding the whole situation hilarious, and going out of his way to make it worse.
*** Until Sanae cheerfully tells him that she wasn't entirely joking about her attraction to Tomoya. He didn't find it so amusing after that.
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* In comics, one adventure [[Superman]] had resulted in acting in a very... [[media:supe.jpg|festive]] manner.
** Another (also featuring kryptonite) had him seeing every member of the Justice League in overly-cartoony chibi-style, using heat vision on the TV when he sucks at video games, and getting a severe case of the munchies.
{{quote| '''Superman''': Wait, do you smell that? Somebody's making ''brownies''. *''Runs to the window and looks out across the vast gulf of space between the Watchtower and Earth''* Yes! Brownies! In ''North Dakota!'' We have to go to North Dakota. ''Right. Now.'' ([http://asylums.insanejournal.com/scans_daily/1073332.html here is a LJ post of the comic])}}
* In Jeff Smith's ''[[Bone]]'', Thorn and Fone Bone get tipsy from hiding in the woods and eating nothing but berries. The berries could have fermented. This happens in [[Real Life]], and birds get drunk from the juice and fly into things. [[Hilarity Ensues]]
* A drug which does this appears in the early ''[[Tintin]]'' albums. In "The Blue Lotus", even Tintin does show the effects after a villain drugs him, although we later find out the drug was exchanged for water. (He was just faking in order to escape.)
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* ''Blind Date'' Kim Basinger's character is allergic to alcohol (with [[Hilarity Ensues|predictable results]] when she imbibes). Bruce Willis injects a box of chocolates with brandy in order to sabotage her wedding to John Larroquette's [[Jerkass]].
* In ''[[Juno]]'':
{{quote| Juno: "I knew this girl who like had this crazy freak out because she took too many behavioral meds at once and she like ripped off her clothes, and dove into the fountain at Ridgedale Mall and was like, "Blah I am a Kraken from the sea!"<br />
(beat)<br />
Su-Chin: "I heard that was you." }}
* In ''Saving Grace'' the two old ladies who run the village store are told that a marijuana plant is an exotic tea. They steal a few leaves and brew them up so they can taste this new tea. They proceed to get stoned, much to the bewilderment of their customers. <ref>THC not being water soluble, this must be tea with milk.</ref>
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* In ''[[Young Guns]]'', When Chavez gets the other main characters to drink Peyote to get them in touch with the "spirit world", they start talking in slow motion and keep seeing chickens. This also leads into a hilarious scene where they ride through an Indian settlement, high as a kite.
* In ''[[History of the World Part One]]'', during the Roman Empire part of the movie, Josephus and Comicus are on the run from the Roman Soldiers. Josephus makes a rather large makeshift joint, and lights it, to use as a smokescreen. The soldiers, hot in pursuit, pass right through the cloud, and... well, [[Intoxication Ensues|Trope Ensues]].
{{quote| Stoned Soldier: Do you care if it falls?<br />
Stoned Soldier: What?<br />
Stoned Soldier: The Roman Empire?<br />
Stoned Soldier: [laughs] Fuck it! }}
* In ''[[State Fair]]'', Melissa Frake enters mincemeat laced with brandy into one of the fair's cooking contests. One of the judges finds it so delicious, not only do he and the other judges award Melissa, but he also takes some extra helpings for himself. A few nights later, this judge's tipsiness lands him a mention in a periodical recapping daily events at the fair. Melissa and her husband Abel encounter him during their night out, and find that he ''still'' feels intoxicated.
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* In [[H. G. Wells]]' ''[[The First Men in the Moon]]'', eating the lunar flora has this effect. The conversation is truly ludicrous.
* Max on Valium, from ''[[Maximum Ride]]''. She has to get drugged up {{spoiler|to get rid of the chip in her arm}}. [[Hilarity Ensues]].
{{quote| "I love you! I love you sooo much!!!"}}
* In ''[[Harry Potter]] and the Order of the Phoenix'', Ron gets hit with a curse that makes him silly for a time. Later, in ''[[Harry Potter]] and the Half Blood Prince.'' Ron accidentally consumes an entire box of sweets dosed with a powerful love potion (originally meant for Harry.)
** The curse is a bit of [[Fridge Horror]]. Between his incoherency and the fact that blood was coming out of his mouth, it was implied that his loopy behavior might have been caused by internal bleeding.
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** Another episode of ''[[That 70s Show]]'' had Donna order a few iced teas while at dinner with Eric. The waiters brought her ''Long Island'' iced teas. Donna tried to drag Eric under the table for a "private rendezvous."
* ''[[Coupling]]'', Jane takes a couple of mystery tablets, reinvents herself as a children's entertainer, creates a sock puppet who insults everybody including her.
{{quote| '''Jane:''' I'm not self-centred.<br />
'''Jake the Snake:''' You're arguing with ''yourself''!<br />
'''Jane:''' Well, so are you! }}
** It should be noted that the "sock puppet" bears a strong resemblance to something else that [[I Call Him "Mister Happy"|someone might nickname "Jake the Snake"...]]
{{quote| '''Sally''': Susan, I'm being mocked by a ''talking penis.''<br />
'''Susan''': I know...<br />
'''Sally''': It took me ''years'' of therapy to stop having that nightmare. }}
* ''[[The Drew Carey Show]]'', an experimental sex drug from DrugCo is dropped in the Buzz Beer tank the day Drew has to go to court.
* A rare dramatic example: in ''[[The Dead Zone]]'', Johnny accidentally inhales a massive dose of ketamine, which renders his normally literal visions bizarre and cryptic.
* On an episode of ''[[Barney Miller]]'', Wojo's girlfriend bakes him brownies which he brings to the station. Of course, they're hash brownies, leading the characters to utter such lines as "Let's go down to the docks and shoot some clams," and "Has anyone seen my legs? They're about ''this'' long."
{{quote| '''Fish:''' First time I felt good in twenty years, it had to be illegal..}}
* Brennan and Angela inadvertently ingest crystal meth at a club in an episode of ''[[Bones]]''. Their goofiness is short-lived, but does result in an exchange that sums up the trope:
{{quote| '''Booth:''' Are you two high?<br />
'''Angela:''' Yes, but only accidentally, so it doesn't count. }}
** In the Christmas episode of the same show and season, the team gets given an antidote for a fungus they might have inhaled. Booth has a bad reaction and pretty much gets high. What makes it even better is he starts doing this after a laundry list of side effects are read off to them, including vomiting and skin rashes, making Hodgens proclaim,
{{quote| "That is ''so'' not fair."}}
** Also, when Booth hurts his back in "The Princess and the Pear," Vicodin "makes the furniture feel friendly"
* President Bartlet on ''[[The West Wing]]'' complains in a first-season episode that his back medication makes him loopy...and is proven right, as when on the painkillers (two different opiates) at the end of the episode, he spaces out, confuses the names of his staff, and announces -- with all the gravitas of the President of the United States -- that he's been seriously thinking about getting a dog.
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* In an episode of ''[[The Naked Brothers Band]]'', Nat acts like this after going to the dentist.
* In an episode of ''[[Taxi]]'' most of the cast gets baked out of their skulls eating Latka's (unintentionally) cocaine-laced cookies.
{{quote| '''Jim:''' They're coca leaves . . . [chew-chew] . . . from Peru . . . [chew-chew] . . . ''southern'' Peru . . . [chew-chew] . . . before the rains . . .}}
** In the episode "Reverend Jim: A Space Odyssey", Jim slips a tranquilizer (or at least something that is ''not'' a Chiclet) into Louie's coffee while the others are trying to figure out how to get Jim a job at the taxi company. It takes effect almost immediately, causing Louie to act significantly nicer than he usually is, start singing, pass out on the hood of one of the taxis, ''and'' agree to giving Jim a job when Bobby asks him.
** In a third episode, Alex is given some uppers and told that they are a headache remedy. He is then summoned to see the boss to explain a minor accident he had been involved in earlier while talking a million miles an hour.
* In the ''[[Firefly]]'' episode "The Train Job", Simon drugs the mercenary Jayne to keep him from causing trouble while waiting for [[The Captain|Mal]] to get back. Jayne manages to get to the cockpit/bridge and yell at Wash for a bit before the drugs take effect and [[Non Sequitur Thud|he passes out]].
{{quote| '''Jayne:''' Now we're finishing this deal, and then maybe, ''maybe'' we'll come back for those morons... got themselves caught... and you can't change that by getting all... bendy.<br />
'''Wash:''' All what?<br />
'''Jayne:''' You got the light... from the console to keep you... lifting you up... they shine like... [starts grabbing at the air] little angels...<br />
[Jayne promptly falls flat onto the floor.]<br />
'''Wash:''' Did he just go crazy and fall asleep? }}
** Simon ''did'' tell Jayne to sit down...
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* A variant from ''[[Perfect Strangers]]'': suffering from a terrible cold on the eve of a big date, with all other options exhausted, cousin Larry agrees to take "the Mypos Cure." Balki mixes up a batch of the [[Gargle Blaster|awful potion]] for Larry, who forces himself to gulp it down when Balki leaves the room... and returns with a tiny spoon, the intended dosage for a single person. Larry just has time to declare to Balki "I can see ''through'' you" before he [[Non Sequitur Thud|passes out]]. He awakens several days later, his date long missed - but hey, his cold is gone!
* [[Stephen Colbert]] marked the demise of (father of LSD) Albert Hoffman when his interns made him a sheet of [[Intoxication Ensues|little stamps]]. [http://www.colbertnation.com/the-colbert-report-videos/167613/may-08-2008/r-i-p--albert-hoffman He decides to pre-lick the entire sheet right away]. The results start at [[Contemplating Your Hands]] and go all the way to an epic [[Breaking the Fourth Wall|fourth-wall-breaking]] freakout over whether he's a real person and why he does the things he does. He ends the show in his set's "fireplace" (a set piece looking like a brick fireplace with a flat-screen TV showing a burning fireplace fire) and claims that the fire looks fake. He had a similar reaction when he briefly ran out of the prescription painkillers he'd become addicted to.
{{quote| "You have your math but he has ''the'' math. I see numbers! And five is very angry. Come back, five!"}}
* ''[[That's My Bush]]'' - After a drug bust, the President takes three hits of ecstasy, which were indistinguishable from run-of-the-mill aspirin.
* The ''[[Black Books]]'' episode "The Blackout" has Manny consuming too many espressos while watching cop shows, leading him to chase a purse snatcher, be mistaken for a plainclothes policeman, and sit in on an interrogation (and nab a confession through his unconventional [[Good Cop, Bad Cop]] performance).
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** In the first episode, Manny, as well as excessive amounts of espresso, accidentally swallows ''The Little Book of Calm'', making him into a sort of stoned, platitude-spouting, Zen... thing.
* In one episode of ''[[House (TV series)|House]]'', House slips a little something in Wilson's coffee...
{{quote| '''Wilson''': I'm not on antidepressants, [[Memetic Mutation|I'm on]] ''[[Memetic Mutation|speeeeeeeeeed]]''!}}
** Milder versions occur all the time on this show, especially with House himself, who at one point takes Methadone for his pain and nearly dies when he falls asleep. One moment he's cheery, the next he's at death's door. Another possible example is when too much Vicodin {{spoiler|causes House to have a powerful halluciation of now-dead Amber, as well as imagining an entire day of Vicodin withdrawal followed by sex with Cuddy. When he realizes it was all just a hallucination, he's so freaked out he voluntarily goes to rehab}}.
** A recent episode had Parks and Taub going to a patient's home to see what was wrong with him. Parks has some ice cream which was laced with LSD. The resulting acid trip is hilarious.
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* ''[[Night Court]]'' also used the "I ordered an iced tea but they brought me a Long Island Iced Tea by mistake" routine with Christine.
* On ''[[How I Met Your Mother]]'' Ted is dared into doing five shots of an unnamed alcoholic drink. He's convinced that, as someone with a "super-brain," he's immune to doing anything stupid. He is wrong.
{{quote| "How easy do you think it would be to sneak into the zoo? I have to see some penguins, like, right now."<br />
"Go into my stable and take my finest stallion. He's yours! His name is Windjammer!" }}
** From the episode, "We're Not From Here":
{{quote| "Marijuana is illegal in the United States, yes, even when baked into a blueberry muffin, that someone might mistakenly eat for breakfast, before leaving for their job as a TV newscaster. 'This just in, look at my hand, how weird is my hand?' is not an appropriate thing to say on the air."}}
** At the end of the episode 'Hooked', Barney takes some of the 'purple pills' the pharmacy girls left behind and ends up saying really random things to Ted and Robin and possibly hallucinating; obviously high.
** It's somewhat of a tradition for Ted, Marshall, and Lily to get high on marijuana together (although Future!Ted insists they were just eating "sandwiches"), leading to a truly ''epic'' instance of this in "Tick Tick Tick", where Ted and Marshall have to make an attempt to go get nachos for Lily while high at a concert, which in their state, seems to them to be a massive, dangerous, bewildering, surreal quest of [[Lord of the Rings]] proportions, although in reality they were only wandering around for two minutes.
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* The female alien protagonist in the short-lived series ''Something is Out There'' has this reaction to caffeine. Later she's smart enough to ask for decaf, but on one occasion the coffee shop attendent has run out, so he secretly gives her the normal stuff, which causes problems as she's talking to a [[Serial Killer]] at the time.
* ''[[The X-Files]]''. In "Three of a Kind" Agent Scully is injected with a brainwashing drug to make her forget some evidence she's uncovered, one of its side-effects being the inhibition of higher reasoning. We later see her enthusiastically flirting with an all-male group of defense contractors and [[The Men in Black]]; fortunately Melvin Frohike hauls her away, much to their disappointment.
{{quote| '''Langley''': So what killed him?<br />
'''Scully''': In my professional opinion? Beeeeeeeeeeep, crash! }}
** The episode [[Rashomon Style|Bad]] [[Our Vampires Are Different|Blood]] featured a drugged Mulder [[Crowning Moment of Funny|singing the theme from "Shaft"]].
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** And of course, Sheldon singing and playing the piano after having a few [[G-Rated Drug|"virgin cuba libres that got a little slutty"]]
* In one episode of ''[[Eleventh Hour]]'', (The American one), Jacob Hood ended up ingesting PCP. However, this was not played for laughs, and instead was taking seriously as he starts talking about philosophy and being alone.
{{quote| If Kraus is correct then we appear to be living in the worst of all possible universes. But if that isn't right then the universe is receding into the threshold of the unknowable. But if Newton is correct, then all matter will dissolve into nothing. The universe is dying and we're all alone.}}
* One season five episode of ''[[NCIS]]'' had Tony on painkillers, which made him act even more crazy than usual.
{{quote| '''Tony:''' [[Contemplating Your Hands|My fingers ... they're finging.]] ''An elevator bell sounds'' [[Crowning Moment of Funny|Ooh!]]}}
* In the second episode of ''[[Nurse Jackie]]'', the tyrannical hospital administrator accidentally gets a full dose of Percocet after stealing what she ''thought'' was Jackie's coffee sweetener. Hilarity ensued.
* [[Family Matters|Urkel]] ends up taking Laura's diet pills which he mistakes for Vitamin C (she hid it in her Vitamin C bottle). He took 4. He ends up acting like he's on speed.
* In [[Glee]], the school nurse Terri (who is moonlighting as a nurse to check up on her husband Will) gives the sleepy Finn some Sudafed (which contains ingredients that also make crystal meth), which causes him to be extremely happy and energetic and gives some to the boys when they perform their mash-up. Rachel later finds out from Kurt and calls Finn and the boys cheaters, but the girls and her decide to take some for their performance as well. Rachel becomes somewhat of a [[Motor Mouth]] while introducing the girls' mash-up.
* An episode of ''[[The Greatest American Hero]]'' has Bill experience a version of this after being shot up with [[Truth Serum]]:
{{quote| "I haven't felt this good since Korea. I ever tell you? Took one in the leg. They gave me a shot. Guy was a ''vet''. The needle.. '''[holds his fingers six inches apart]'''.. I was out for a week. It was ''great!''"}}
** He gives a loopy but basically accurate description of Ralph and the [[Clothes Make the Superman|supersuit]], but by then his interrogaters are convinced that [[Cassandra Truth|he's just babbling]].
* ''[[Will and Grace]]'' had an episode in which Jack became addicted to coffee, and he bursts into Will and Grace's apartment in the beginning of the episode with a frenzied monologue that must be quoted in its entirety:
{{quote| '''Jack:''' ''(very rapidly, drinking iced coffee)'' Hey, friends, lovers, mothers, and other strangers. You're never going to believe what happened to me. ''(almost trips)'' Oh, my gosh! Did you see that? I almost did the half nelson. I almost bruised my delicates, my delicates, my domo arigato Mr. Tomatoes. ''(takes a huge belt of coffee)'' Huge news! I have met--are you ready for this? Mr. Right. Well, Mr. Right-Now, anyway. Ba-da-bum! Good night, folks, I'm here all week. Jack 2000! He works over at the Jumpin' Java. You know that coffee shop on 72nd? And his name is Paul. He is cute with a capital "Q"! And the busier it gets, the hotter he gets. And the hotter he gets, the sweatier he gets. And the sweatier he gets-- I forgot where I'm going with this, but the point is... ''(drinks again)'' Me likey he, and he likey me. And the best part is--shaZAM--he gives me free iced coffee every time I go in, which is every hour on the hour. Thank you very much! And occasionally on the half hour! ''(sing-song)'' Bah-da-da-da-da! Blblblbt! ''(exits, to much applause from the studio audience)''}}
** Also lampshaded in another episode where Will becomes 'addicted' to his painkillers in the course of a weekend after falling off his "man-clog," exhibiting laid-back behavior which disturbs Grace: "Okay, now you're freakin' me out!! There are crumbs on the carpet, your robe doesn't match your socks, and, oh, my God, there's no product in your hair! I'm calling 9-1-1!" (Episode also features the line "oooh, crackwhores are sneaky!", which this troper finds very quotable.)
* In the ''[[Mork and Mindy]]'' episode, "Mork and the Family Reunion", Mindy accidentally eats [[Alien Lunch|an Orkan delicacy called flek]], and [[Intoxication Ensues|begins performing spontaneous gymnastics and acting, well, Mork-like]]. Later, Mindy's uncle (played by none other than [[Robin Williams]]' [[Rapid-Fire Comedy]] idol, Jonathan Winters) eats some and [[Hilarity Ensues]] [[Crowning Moment of Funny|big time]].
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** And later, when Elliot {{spoiler|fakes mushroom intoxication in court}}: "It's so hot in here. I didn't order that pizza. I'm not even a fan of anchovies!"
* After [[3rd Rock from the Sun|the aliens]] first discover dreams, Dick goes to a psychiatrist and gets antidepressants to help deal with his issues. He takes one, then another when it doesn't immediately kick in like he'd hoped, and another, and another...
{{quote| '''TOMMY:''' So how was work today, Dick?<br />
'''DICK:''' (stoned) Oh, just fine.<br />
'''SALLY:''' How'd it go with Albright, Dick?<br />
'''DICK:''' Oh, just fine.<br />
'''HARRY:''' How'd it feel to have broken glass rubbed in your eye?<br />
'''DICK:''' Just fine. }}
* One episode of ''[[Stargate Atlantis]]'' has Rodney injecting himself with a massive dose of [[Psycho Serum|Wraith enzyme]] to take out his guards and escape. [http://www.youtube.com/watch?v=8V_k66CEap0 Once he gets home however...]
* This seems to happen ''a lot'' on ''[[Party Down]]''. There's Roman high on weed brownies, Lydia accidentally powdering her nose with cocaine, Ron downing a bottle of Henry's Vicodin, Ron high on marijuanu fumes while spending time with rappers, Bobbie on 'shrooms, Constance... on various drugs pretty much all of the time...
* Happens in the second-season finale of ''[[Farscape]]'': having being badly burned in the previous episode, [[Living Ship|Moya]] is in serious pain, so the crew find a doctor who can provide a suitable anaesthetic while the healing process continues. However, the anaesthetic is provided in the form of a gas, which has to be liberally hosed around the affected areas, and because nobody has a proper gas mask aboard, Stark and D'Argo end up a little bit loopy while applying it.
{{quote| '''Stark:''' Thaaasssit, D'Argo.<br />
'''D'Argo:''' I caaaa' feel my tongue.<br />
'''Stark:''' Who'sssss ffffault izzat?<br />
'''D'Argo:''' Aw fwell you... (trails off incomprehensibly) }}
** Doubly hilarious, Moya's symbiotic Pilot ends up even higher than them when the anaesthetic reaches his nervous system, insisting that he's perfectly fine even while giggling and slurring all over the place. Oh, and providing this line: "I am no higher in life than I've even been; my position is fixed!"
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* Meatwad of ''[[Aqua Teen Hunger Force]]'' once had an episode like this, wherein he ingested some expired "cheese" that made him believe he could predict the future whenever he touched people. He began predicting disasters that turned out to be minor annoyances, such as milk going bad or the garbage stinking. In the end, it was revealed that the "cheese" he ate was actually caulk, and a ''listed'' side effect of its ingestion is "making you think you can see the future but you can't".
* In ''[[Daria]]'', Jake picks several unfamiliar berries while the family is out camping, which all but Daria eat. Soon, Jake and Helen are chasing after his spirit animal, while Quinn tries to use a mudpuddle as makeup; in the end, Daria has to call for them to be airlifted to a hospital.
{{quote| '''Quinn:''' But why did they go insane?<br />
'''Daria:''' Knowing Dad and his excellent woodland skills, I'd say it was the berries. Except...<br />
'''Quinn:''' It couldn't have been the berries.<br />
'''Daria:''' That's what I think. You ate them too and you seem okay.<br />
'''Quinn:''' No, I meant because those weren't the glitter berries.<br />
'''Daria:''' Glitter berries?<br />
'''Quinn:''' You know, the glitter berries! The ones that fill your mouth with beautiful sparkling glitter when you bite into them. Those are the ones that make you act weird. I mean until you spread your shimmering wings and fly away.<br />
'''Daria:''' Uh-oh. }}
* ''[[Futurama]]'':
** Lrr, Emperor of Omicron Persei 8, eats a hippie right before delivering a speech in "The Problem with Popplers", and ends up [[Contemplating Your Hands|rambling about his hands]].
{{quote| "Urg... I think there was something funny in that hippie. People of Earth - oh, that hippie's starting to kick in - we've all learned a valuable lesson today, I realize now that - dude! My hands are huge! They can touch anything but themselves. (touches them together) Oh, wait."}}
** Dr. Zoidberg is injected with painkillers in "Bender Gets Made": "Why always with the fighting?"
{{quote| [[Contemplating Your Hands|Clack... clack.]] And then minutes later: "Oh God, ''I'm coming down!!''"}}
** The essence of pure flavor is nothing more than water. Water laced with LSD.
* An episode of ''[[Dexter's Laboratory]]'' has him and Dee-Dee try coffee to see what all the fuss is about. They end up consuming all the coffee in the house and going on a hyperactive bender. Meanwhile their parents learn that they are out of coffee and go through the effects of withdrawal. Interesting fact: while Dee-Dee spent her excessive energy playing plenty of different games and activities, Dexter keeps tightening the same bolt for possibly ''hours'', all while smiling like a stoner.
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** In one episode the characters see an ad for non-alcoholic beer, which excites them when they find out you don't have to be 21 to buy it. After purchasing a pack, they sit on a sidewalk and try to become drunk ("We're fhit-saced!"). A cop comes by and gives them a test ("I'm too drunk to take a test!") which they naturally fail. The cop eventually sees that the beer isn't alcoholic, and tells them that they aren't drunk; they're just stupid. Disappointed that they aren't drunk, the two decide that all they need to do is drink more beer.
** There's also [[The Movie]], in which Beavis takes a bite of peyote in a desert and experiences [http://www.youtube.com/watch?v=A95qnv-oIuo a musical trip.]
{{quote| '''Beavis:''' Woah, this is cool! It's like... it's like everything looks all weird, and... ''woah!'' It's like there's all these weird shapes an'... it's sorta like... it's like a... [[Mythology Gag|it's like a music video!!]]}}
* Whenever Mac from ''[[Foster's Home for Imaginary Friends]]'' consumes sugar, he gets extremely hyper. In the first episode it happened he [[Naked People Are Funny|ripped off all of his clothes]] and ran out of the house and into town.
* In the ''[[Space Ghost Coast to Coast]]'' episode "Flipmode", Space Ghost gets high on gas fumes:
{{quote| '''Space Ghost''': Look: bean prints on the wrench. But what is the wrench for?<br />
'''Moltar''': That's for where you were trying to fix the gas leak, and you made it leak.<br />
'''Space Ghost''': Is that where I got all these ideas? 'Cause they're brilliant! Hey, Break all the pipes in the sub for more good ideas! Dive! Dive! Suck on the pipes! }}
* Occurs on ''[[The Simpsons]]''. In "Selma's Choice", Lisa drinks the water from a flume ride and declares "I am the Lizard Queen!" in parody of Jim Morrison.
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* Abigail and Amelia's uncle Waldo from ''[[The Aristocats]]'', who was thrown out of a restaurant after a failed attempt at cooking. He had been basted (more like marinated) in white wine. "Oh, you are just too much!" "You mean he's had too much."
* In ''[[The Iron Giant]]'', Hogarth drinks some of Dean's espresso, insisting he could handle it. The following exchange takes roughly fifteen seconds:
{{quote| '''Hogarth''': So she moved me up a grade 'cause I wasn't fitting in, so now I'm even more not fitting in. I was getting good grades, you know, like all A's. So my mom says, "You need stimulation," and I go, "No, I'm stimulated enough right now."<br />
'''Dean''': That's for sure.<br />
'''Hogarth''': So she says, "Uh-uh, You don't have a challenge, you need a challenge." So now I'm challenged, all right, I'm challenged to hold on to my lunch money because of all the big mooses who wanna pound me, 'cause they think I'm a shrimpy dork who thinks he's smarter than them! But I don't think I'm smarter, I just do the stupid homework! If everyone else JUST DID THE STUPID HOMEWORK, they could move up a grade and get pounded, too! Is there any more coffee? }}
* In an episode of ''[[Ruby Gloom]]'', Misery overdoses on sugar. This being Misery, she starts running around the house, hyperactively reeling off disasters as they come to mind. ("Holland, 1134 -- SEA FLOOD! ''That's a lot of water...''")
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