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* A medical lobotomy is used for this purpose in ''[[One Flew Over the Cuckoo's Nest]]'' to get rid of a particularly troublesome patient - {{spoiler|the protagonist, in fact}}.
* Likewise, the impending use of a lobotomy to achieve this end hangs over Baby Doll's head throughout most of ''[[Sucker Punch]]''. The original purpose is to make it impossible for her to give testimony about her stepfather's crimes, though, rather than to make her stop causing trouble in the institution.
* In ''<nowiki>
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* When [[Megamind]] visits the monument to Metro Man, he reminisces about old times and brings up an "Illiteracy Ray", a rather specific variant on this trope.
* In ''[[Super Mario Bros. (film)|Super Mario Bros]]'', Koopa uses the tactic to [[Hollywood Evolution|de-evolve]] his oppositors into mindless Goombas.
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* ''[[Rocky and Bullwinkle]]'' had Goof Gas in one arc. "One poof, you're a goof!" as Boris puts it.
** [[The Ditz|Doesn't work on Bullwinkle, though.]]
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* In the ''[[Lilo and Stitch]]'' cartoon series, Jumbaa reveals that one of his earlier experiments had quills that contained a venom which reduces anybody's intelligence to 1% of it's original functionality.
* [[SpongeBob SquarePants|Mermaid Man and Barnacle Boy]] have the "Orb of Confusion", a literal [[Idiot Ball]] which turns anyone in its range into a drooling idiot. Unfortunately, the range of the Orb is only a few feet, so it only affects the holders.
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