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'''Warning''': ''This Synopsis is spoiler-heavy.''
''
The film takes places over several years, following the life of Eddie Jessup (William Hurt), a brilliant research scientist who believes that altered states of consciousness are as real as every day reality, and investigates the religious experience in schizophrenics. He and his friend and fellow scientist Arthur, played by Bob Balaban, experiment with altered states of consciousness using isolation tank studies. Jessup marries a [[Hot Scientist]] (hot physical anthropologist, actually), Emily, played by Blair Brown. They have a child together, but the marriage is strained by her groundedness and his wild, out-there intellectual passions.
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** On top of the general [[Mushroom Samba]] [[Popcultural Osmosis]] [[South Park]] has used, it also explicitly re-used the film's ending with Cartman in "Tsst".
** Or Charlie on ''[[Lost]]'' when Locke commences a vision quest: "I'm going to stand out here in case you devolve into a monkey."
*** J. J. Abrahms must be a fan of this movie: the pilot of ''[[Fringe]]'' is loaded with homages to ''
** The music video of [[A-ha]]'s "Take On Me" followed the scene where Eddie Jessup is slamming himself against the wall to break out of his manifested altered state and return to normal reality, only in the video the guy was trying to slam himself out of a sketched self into reality. Both were motivated by the [[Power of Love]].
* [[Professor Guinea Pig]]: Eddie Jessop, obviously.
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