• Cross-Dressing Voices: Linda and Tina are voiced by Dan Mintz and John Roberts (the latter of whom makes little attempt, if any, to sound female, which actually works for the character) and the Pesto twins are voiced by Sarah Silverman and her sister.
    • For that matter, most of the one-shot/background female characters seem to be played by men, too.
  • Development Gag: The original pitch had the Belchers as cannibals who served ground human meat in their burgers. That got thrown out, but the pilot is still about the Belchers being suspected cannibals who serve human burgers.
  • One of Us: It's been fairly popular for fans of the show to call Tina their "Spirit Animal".
  • What Might Have Been: In the original pitch of the show, Bob and his family were cannibals. They would have served ground-up human meat to unwitting customers, while trying to keep the authorities off their trail. Needless to say, the final version is quite a bit different.
    • The pilot episode is basically one long reference to the aborted original premise. Thanks to a false rumor, everyone in town thinks Bob is a cannibal, and he's forced to get the meat tested to prove it's just beef.