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== Web Original ==
* Apollo and Calliope in ''[[Thalia's Musings]]'', except on rare occasions when Calliope is drunk.
*Aiden and Lake in ''Disventure Camp'' are rather close. Their relationship is justified due to Aiden being transsexual and Lake being a lesbian.
*In addition to Aiden and Lake, there’s also Hunter and Tess. Hunter is in a relationship with Ally but the two are still close.
== Western Animation ==
* Flash and Hawkgirl in ''[[Justice League]]''. Any flirting between these two can be entirely attributed to Flash's tendency to hit on [[Handsome Lech|anything in a skirt]], and even that stops by the shift to ''[[Justice League Unlimited]]''. He even describes her as being like his "big sister" in the final season of the series.
* Also from ''[[DCAU]]'', this is how [[Superman|Clark Kent]] seems to have come to view his ex Lana Lang, though she threatens to go back to [[Lex Luthor]] if he ever calls her that.
* Lance and Illana from ''[[Sym-Bionic Titan]]'' poses as siblings in their high school. Gennedy Tartakovsky said before there was to be no romance between those two.
* Terry (Batman) and Maxine in ''[[Batman Beyond]]'' have this, being really really close. Although many fans think they'd just be better off dating, neither charaters actually show any interest in the other that way.
** [[Word of God]] states they were thinking of actually [[What Could Have Been|making them a couple]], but the creator decided to have them stay purely as friends.
* Played with in ''[[Harvey Birdman, Attorney at Law]]'':
{{quote|'''Birdgirl:''' You realize there's absolutely no chance we'll be kissing, right?
'''Peanut:''' Yeah, d'uh, of course; you're like my sister. (pause) Which given a little thought could be a very hot concept. }}
* The titular character and Ingrid Third in "Fillmore" are the Safety Patrol's best officers and friends.
* Henry and June from ''[[KaBlam!]]'', [https://web.archive.org/web/20110918235116/http://s1.zetaboards.com/The_KaBlam_Forum/topic/4265635/1 according to] [[Word of God]].
* In the ''[[Brandy and Mr. Whiskers]]'' theme song, the eponymous duo are described as "like a dysfunctional brother and sister."
== Real Life ==
* This is quite common in real life amongst childhood friends. Studies show that children who know each other during their early childhood will rarely develop any romantic interest later in life. It's hypothesized that this is part of an instinctual mechanism designed to minimize the possibility of [[Incest Is Relative|inbreeding]]. It's called [[wikipedia:Westermarck effect|Westermarck effect]]. But do Middle/High schoolers with those two friends who have known each other since preschool care? Nooooooo....
* [[Leonardo DiCaprio]] and [[Kate Winslet]], having been very close friends after [[Titanic]] and collaborated again in [[Revolutionary Road]] and nothing more. [[Actor Shipping|Shippers]] disagree. Kate's kids call him "Uncle Leo", and for a kissing scene in [[Revolutionary Road]], Leonardo stated that it felt slightly weird because kissing Kate was like kissing a family member.
* ''[[Harry Potter]]'' actors [[Rupert Grint]] and [[Emma Watson]] said it was weird to kiss each other for the eighth and last movie because they had grown up together since the first one and thought of each other as brother and sister. Same when Emma had to kiss [[Daniel Radcliffe]] (though the relevant scene itself was already decidedly unpleasant in context).
* Arguably the luckiest of King Henry VIII's wives was [[wikipedia:Anne of Cleves|Anne of Cleves]]. Misled by flattering portraits on both ends and a need for a political alliance, they married. As soon as it was time to consumate things, the pair found out that there was absolutely ''zero'' attraction and Henry opted for an annullment. Lucky Anne, though, kept in good standing with Henry, and became known as the "King's beloved sister."
* David Faustino denied that there was ever any romance between him and Christina Applegate on ''[[Married... with Children]]'', instead defining their relationship as this trope.
* [[Jennette McCurdy]] has specifically said that kissing [[Nathan Kress]] feels like kissing a brother, and it's part of the reason some fans see the relationship of Sam and Freddie in the 5th season of ''[[iCarly]]'' as being subject to [[Shipping Bed Death]] due to the lack romantic chemistry.
* During an interview with [[Craig Ferguson]], [[Jet Li]] literally stated that his fellow actress [[Michelle Yeoh]], whom he had quite some history working with, is "Like a brother to me".
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