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* ''[[Gattaca]]''
* ''[[Repo! The Genetic Opera]]''
* Arguably, the protagonists in the ''[[Tetsuo:
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* ''[[Half-Life 2]]''. "Transhuman" is a [[Transhuman Treachery|politically loaded]] word in the ''Half-Life'' [[Vichy Earth|universe]].
** To clarify, any human who volunteers to join the Overwatch is brainwashed, gutted, dismembered, and rebuilt as a cyborg. [[Cybernetics Eat Your Soul|The augmentations make them entirely dependent on the Combine.]]
* ''[[
* ''[[Command & Conquer]]''. Mostly Nod cyborgs and Yuri's psychic army.
* ''[[
* Alice Margatroid from [[Touhou]] used to be human, but transformed into a magician as a species.
* In the [[Sequel Series|series that follow on]] from ''[[Mega Man X]]'', this becomes the [[Take a Third Option|third option]] solution to the [[Robot War]] that has plagued human- and Reploidkind for hundreds of years.
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