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* Grove in ''[[Vampire Hunter D]]'' is in the latest stages of this.
* In ''[[Death Note]]'' , humans can acquire the ability to see people's names and lifespans [[Deadly Upgrade|at the cost of half their own life.]]
* In ''[[Witchblade (anime)|Witchblade]]'' it is an inevitability that all who are equipped with and use
** If you take it in context of [[Witchblade (Comic Book)|the larger canon]] — that's what happens if Witchblade has only a minute or two to pick the new wielder from those in range: a slightly-above-average human is not up to this, whether physically or mentally.
* ''[[Chrono Crusade]]'' has an interesting variation of this. When Chrono uses his powers, he doesn't suffer any sort of decay -- ''[[Beast and Beauty|Rosette]]'' does, as they're powered by her soul. [[Your Days Are Numbered|In the best circumstances, she's only expected to live until thirty]]. Since Chrono has a [[Bodyguard Crush]] on her, he's not really happy about this.
* In ''[[D.Gray-man|D Gray Man]]'', anyone with a parasite-type Innocence tends to have a much shorter than average life expectancy, even outside of the whole "constantly fighting freaky-ass monsters" issue. Considering that this includes [[Cute Shotaro Boy|the hero]], it's no wonder he's [[The Woobie]].
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* ''[[Warhammer 40,000]]'': Psykers get a double-shot of awfulness: not only does the act of using their powers leave the potential of letting a [[Our Demons Are Different|Warp daemon]] take over their body and open a Warp Rift with their mind, but many of the granted abilities take a severe toll on the body, leaving them exhausted, injured through strain and sometimes dead from the brain [[Your Head Asplode|literally tearing itself apart]]. How to avoid this and still be a functioning psyhic? Heavy [[Cybernetics Eat Your Soul|cybernetic augmentation]], or "soul binding" which tends to do things like [[Eye Scream|pop your eyeballs]] and kill all your emotions. All things considered though, this is a small price to pay to potentially be an incredibly powerful being in an [[Crapsack World|unbelievably brutal an unforgiving galaxy]].
* A relatively obscure alternate form of spellcasting in ''[[Dungeons & Dragons]] 3.5'' called chaos casting has this as a caveat : instead of using a spell slot system with a limited selection of spells, chaos casting allows the caster to create every spell on the fly and [[Cast From Hit Points|casting deals nonlethal damage that can only be healed by a full night rest to the caster.]] Except every spell requires a Spellcraft check to succeed (difficulty depending on the level of the spell created), and failing has a chance to apply a permanent negative effect to the caster who either [[Sanity Slippage|slowly goes insane]] or [[Body Horror|suffers awful physical transformations]]. Too many failures lead to [[Deader Than Dead|permanent, irreversible death.]]
* ''[[Stars Without Number]]''/''Other Dust'' has "torching" for psychics out of power, but pushing on, or not properly trained.
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