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* In ''[[Shadow Hearts]] II'', this is the insult to injury of the Mistletoe Curse. The harder Yuri fights against it, the faster it develops {{spoiler|and kills his memories}}. But if doesn't resist at all, it'll gradually overtake him anyway. Fortunately {{spoiler|nothing. There's no cure. There's a happy ending anyway, though. Kinda.}}
* Tellah's [[Dangerous Forbidden Technique|Meteo]] from ''[[Final Fantasy IV]]''.
** Ceodore's Awaken in ''[[Final Fantasy IV:
** The series' [[Cast From Hit Points|Dark Knight]] class may be susceptible to this in the hands of a reckless player.
* Batman comes dangerously close to this by the end of ''[[Batman: Arkham Asylum]]''. As the game progresses, his suit slowly becomes more and more tattered (tears on his suit and cape, scratches on his face and cowl, five-o'clock shadow, bloodshot eyes), culminating in Batman intentionally {{spoiler|[[Megaton Punch|punching out a Titan-infused Joker with a fist covered in explosive gel]], mangling his gauntlet}}.
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