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* In the [[Captain Atom]] / Wildstorm crossover, Cap does this to Voodoo when she tried to invade his mind. He uses his neural uplink to the Pentagon's computer net to basically KO her with the Internet.
* In his first appearance, The Leader - [[Super Intelligence|superintelligent]] enemy of the [[Incredible Hulk (Comic Book)|Incredible Hulk]] - was after an Ultimate Machine containing all the knowledge in the Universe. When he obtained it and downloaded the information in his mind, this proved too much even for his super brain and killed him. [[Only Mostly Dead|Seemingly]].
* In an issue of ''[[Dylan Dog]]'', a scientist is looking for a way to [[Ninety Percent90% of Your Brain|unlock the full potential of the human intellect]], but all of his test subjects die in [[Your Head Asplode|predictably gruesome ways]]. It turns out that an adult's intellect is "atrophied" after a life of underuse, and only babies are flexible enough to survive the process. When the scientist, mentally unbalanced after years of frustrations, experiments on his newborn daughter, it finally works [[Gone Horribly Right|even too well]].
 
 
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** In ''[[Stargate Atlantis (TV)|Stargate Atlantis]]'', a hyper-evolution machine gives Rodney McKay amazing mental powers (including psychic ones such as mind reading and telekinesis) - but at the cost of it eventually killing off the part of his brain that controls the lower functions such as his heartbeat. It's at the last moment of his life that he manages to figure out (using his amazing intellect) how to reverse the process to return to normal.
* This ''almost'' happened to Max in an episode of ''[[Dark Angel]]'' which involved her taking a rival series clone's neural implant and installing it into her own brain. The strain nearly burnt out her nervous system.
* ''[[Doctor Who (TV)|Doctor Who]]''
** [[Russell T Davies]] is clearly very fond of this -- back in the 1st series finale, Rose absorbs the time vortex, making her effectively a goddess, but is in danger of being "burned up" by the power and whispers, "I can see everything. The sun and the moon, the day and the night -- but why do they hurt? My head... is killing me."
** {{spoiler|Donna has all of the Doctor's mind copied into her head; combined with human ingenuity, this makes her even cleverer than the Doctor. But her mind cannot take it, and the only way to save her is to [[Victory -Guided Amnesia|remove all memories she has of the Doctor and their adventures]].}}
** In {{spoiler|a fatal example from}}"Forest of the Dead" {{spoiler|River Song uses her own brain as a data buffer to download the Library survivors out of the core, killing her in the process}}
* Though it doesn't seem to be actually dangerous, in ''The Second Coming'' Steve (played by future [[Doctor Who (TV)|ninth Doctor]] Christopher Eccleston), discovers that he's the literal son of God, and compares the experience of accessing divine omniscience with a human brain as like "downloading fifty-million megabits into a pocket calculator," and admits that it hurts.
* Lt. Barclay in ''[[Star Trek the Next Generation]]'' episode "The Nth Degree", although the newly gained super-intelligence doesn't seem to be dangerous in itself. The problem comes when he connects his brain directly to the ship's computer. He uploads himself and uses the extra processing power to expand his intelligence, but then realizes that his brain alone would be too small to contain it, so he's stuck in the computer [[Reset Button|until the end of the episode]].
* On ''[[Andromeda]]'', Harper had a database downloaded into his brain (he has a computer port on his neck), and it played out similar to ''SG-1'', only instead of being directed to a single goal like O'Neill, Harper began and abandoned dozens of projects.
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== Western Animation ==
* ''[[Code Lyoko]]'' example: Jérémie once tried to use the same quantum memory technology that powered the Supercomputer to enhance his own brainpower. Of course, it backfired due to both the immense physical strain and the fact that XANA introduced the possibility of that maneuver as a [[Red Herring]].
* In an episode of the ''[[Men in Black (Animation)|Men in Black]]'' animated series, [[ET Gave Us Wi Fi|aliens bring to Earth a "Cerebral Accelerator" that boosts human intelligence]]. Agent J tries it on before MiB has a chance to safety-test it for side-effects and learns the device gives him [[Ripple -Effect -Proof Memory]] but will eventually make [[Your Head Asplode|his head a splode]].
* The episode of ''[[Jimmy Neutron Boy Genius]]'' where Sheen, who is somewhere between [[The Ditz]] and a [[Cloudcuckoolander]], is hit with Jimmy's brain-gain helmet, [[What an Idiot!|without fixing the issue of the original brain-drain helmet]], a limiter. Sheen gets outstanding [[Psychic Powers]], an [[A God Am I]] complex, and [[Refuge in Audacity|a head the size of a]] ''[[Refuge in Audacity|house]]'' before the [[Reset Button]] is hit.
** At one point, Jimmy calculates the maximum possible number Sheen's IQ could grow to. ''[[Serial Escalation|It hits infinity.]]''
* This is used against a villain in one episode of ''[[Darkwing Duck]]''. In the final showdown, DW and Launchpad get their hands on the [[Shout -Out|Norma Ray]], a device that increases your IQ as long as you clear your mind of all thought (but gives the user the nasty side effect of having a [[My Brain Is Big|literal]] [[Insufferable Genius|and figurative]] "swelled head"). They bombard the villain with rays while asking him a bunch of tough questions at once, causing him to lose his concentration and [[Your Head Asplode|make his head so big that it blows up]].
** Not just IQ. The device also gives you ridiculous [[Psychic Powers]], ranging from prescience to manifestation (Launchpad materialized a giant fridge out of thin air).
* Happens to [[Spongebob SquarePants]] of all people, in the episode ''Squilliam returns''. Squidward turns the Krusty Krab into a fine dining establishment to impress Squilliam, and Spongebob is to wait tables. After learning everything associated with fine dining, [[My Skull Runneth Over|his skull runneth over]] [[Up to Eleven|badly]] -- he cannot even remember his own name any more! The only thing he can remember, except for fine dining, is breathing.
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* Also people with [[Eidetic Memory]] can set off a memory at any time by some random thing, be it good or bad.
* Subverted by people who have suffered the loss of a substantial portion of their brains, due to strokes, tumors, accidents or surgery, yet continue to function and accumulate memories normally throughout their lives. Even patients who have entire cerebral hemispheres removed to halt their epileptic seizures don't "run out" of memory-space, despite having only 50% storage capacity.
* In either Ripley's Believe It Or Not, or Guinness Book Of Records, there was an account of a girl who at age 14 had learned fluency, and was writing papers in about twelve different languages. She ended up dying at about age 16 [[Ninety Percent90% of Your Brain|(possibly from a seizure)]].
* Certain kinds of autistic patients known as ''savants'' make up for their seemingly handicapped social skills with superhuman computational ability.
* Solomon Shereshevskii, a Russian mnemotist (who did not, in fact, have an [[Eidetic Memory]]) had the ability to remember things so well that he became dislocated in time; he eventually became unable to tell whether the thing you just told him happened 5 minutes or 5 years ago. He had to literally learn to mentally remove facts from his memory (in other words, deliberately forget). It didn't help that he had fivefold synaesthesia, an extremely strong form of synaesthesia in which stimulating one sense meant a reaction from them ''all''. [[That Other Wiki]] [http://en.[wikipedia.org/wiki/Solomon_Shereshevskii:Solomon Shereshevskii|has an article on him]].
* One of the theorized causes of old age dementia is that your brain reaches its effective capacity, and then stops working properly.
** This is supported by the behavior of computers that are built to mimic neural architecture and then overloaded with data.
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[[Category:Memory Tropes]]
[[Category:My Skull Runneth Over]]
[[Category:Trope]]
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