The Wolf Man/Tear Jerker

Really, the last twenty minutes of the movie. Gwen accepts Lawrence despite all the, you know, murder charges when he sees the pentagram in her hand (meaning he's going to kill her Because Destiny Says So), and runs off, trying to protect her. This fails pretty miserably, and the only thing that keeps him from killing his one true love is being (slowly) beaten to death by his father with the same cane that had been a big part of his first meeting with said one true love. The sequels reveal that the experience was so heartbreaking that John died of a broken heart pretty much immediately afterwards.

The ending...dear god the ending.
- This troper's heart got jerked particularly hard when Lawrence is begging someone to kill him right before he transforms for the second time, this time in a room full of doctors and spectators.
- No love for the end of the Madness Montage, when Gwen comes to visit and tries desperately to calm him down, all while he's clearly hurt and scared and having hallucinations of werewolves lunging at him. Even worse is the fact that it's entirely possible that Gwen wasn't there at all.