Book Ends/Web Comics

Note that some Book Ends can be spoilers, so beware.

Examples of Book Ends in Web Comics include:

This happened in the first story of Honeydew Syndrome (the first five chapters).
In the second panel of the first strip of 1/0, "Let there be light!" In the second panel of the last strip, "Let there be darkness!"
David Willis loves this trope. Compare the first and second Roomies! strips with the final Roomies! strip, and (to a lesser extent) the first two Roomies! with this Joyce and Walky! which debuted two days after the Walkyverse's tenth anniversary.
Each volume of Ménage à 3 begins and ends with similar NSFW scenes. The first volume opens with Gary walking in on Matt and Dillon having sex on the couch and ends with Dillon walking in on Matt and Sandra having sex in about the same position. The second volume opens with Gary having an Erotic Dream about Zii in which she turns out to be a man and ends with Yuki having an Erotic Dream about a girl who turns out to be a female Gary. The third volume opens with Sandra waking up on DiDi's boobs, and ends with her waking up on Senna's.
8-Bit Theater begins with Black Mage and Fighter lost while searching for a MacGuffin in the beginning. In the epilogue, they're once again lost while searching for another quest, and Fighter suggests they continue looking for the very same MacGuffin.
Concerned: The Half-life and Death of Gordon Frohman begins and ends with a snide joke about Valve's constant delays in releasing games.
Though not in the chronologically-first strips, Girly created these with the New First Comics and the Grand Finale.
Problem Sleuth begins with a particularly hard-boiled Private Eye Monologue delivered by the titular Problem Sleuth. After Problem Sleuth has performed Sepulchritude and used The Final Flip-Out, he's on the verge of death, where the original monologue's structure is used, except this time, it's talking about how he's in limbo.
The first Concession comic is mirrored by the appropriately-titled fifth-to-last comic. The Alt Text confirms that it is indeed the same customer.
The Phoenix Requiem begins with a celebration of "All Souls' Night" (in that setting it has similar importance than our Christmas/New Year's Eve). The comic ends with the same celebration 2 years later. The first scene begins with Jonas arriving. The last one ends the same way.
Homestuck did a variation at the end of its fourth act - the final scene of the end-of-act Animation Bump is of a meteor from the Reckoning passing through one of Skaia's defensive gates and striking John's house, which is exactly what happened in the conclusion of Act 1 and what kickstarted the adventure to begin with.
- The end-of-Act 5 Animation Bump did the same thing: to represent all of the kids' reality being fundamentally reset by the Scratch, when Jade is enlarging the Fourth Wall for her and John to travel through, it displays a rapidly-reversing slideshow of many of the earliest panels of Homestuck, ending with the very first page of John standing in his room before cutting to white.
- The first pesterlog of Act 5 Act 2 ended with John telling Karkat "See you soon". The last pesterlog starts with Karkat repeating the same line to Jade.
Irregular Webcomic: "Hey, there's comics on the Internet!" Keep in mind that 2011 David Morgan-Mar's soul was transported back into his 2002 body and Death made him forget everything that happened over IWC!'s run. Also, #3182 is only the Grand Finale of the main arcs; guest comics and Annotation comics have been posted since.
Darken both starts and ends with a character being resurrected to serve a demon lord.

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