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* Attempted in the anime ''[[Speed Grapher]]''; however, since the "experiment" involved {{spoiler|''raping a 15-year-old girl''}}, all for the better that it wasn't carried out.
* Somewhat used in ''[[Pokémon (anime)|Pokémon]]'': the Pokémon researcher Bill stuffs himself inside a Kabuto costume to find out what it feels like. See the video games section for the more on-the-spot version from the games.
* {{spoiler|Kiriko}} resorts to this with the last vaccine in ''[[
* Averted in ''[[Franken Fran]]'': the eponymous character doesn't test a treatment she developed for aging on herself because, as she herself puts it, "It's just too scary~". {{spoiler|For good reason: she based it on telomerase...and cells that have too much of it turn cancerous. Her client, who ordered her killed so she could keep all the research to herself, ends up testing it by self injection...[[Laser-Guided Karma|and is]] [[Body Horror|ultimately turned]] [[Fate Worse Than Death|into a huge cancerous blob]].}}
* Kurotsuchi Mayuri of ''[[Bleach]]'' is obviously his own favorite test subject...although based on what is known of his personality, most of his "improvements" were probably perfected on the unwilling first.
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* ''[[Star Trek: Enterprise]]''. In the episode "Daedalus" Emory Erickson, the wheelchair-bound inventor of the [[Teleporters and Transporters|transporter]], is shown receiving an injection from his daughter—his back and spine are grossly distorted, implying a failed transporter experiment.
* Semi-averted in an episode of ''[[The Saint]]'', where a man with a heart condition wanted to use cryogenics until open heart surgery was commonplace. He did several animal testing, and ''wanted'' to start human testing with [[The Hero|somebody else]], but at the end of the episode, Simon Templar escaped and a heart attack forced the man to enter his machine in emergency.
* ''[[V (TV series)||V: The Final Battle]]''. The dust used to kill the Visitors is tested on an alien prisoner. Then while the others are busy arguing about whether they should find a human collaborator to test it on, the [[Hot Scientist]] steps into the chamber instead.
* In the first nationally broadcast season of ''[[Mystery Science Theater 3000]]'', as well as the one that came before it, Dr. Laurence "Larry" Erhardt was an involuntary version: Dr. Forrester would test experiments on him (often against his will.) The more interesting ones included cold fusion being created within Erhardt's mouth and making him sweat through his tongue. TV's Frank would later take on this role, but not technically being a scientist he's just a plain [[Guinea Pig]].
* On ''[[Lost]]'', it seems that Daniel Faraday {{spoiler|tested his [[Mental Time Travel|time machine]] on himself}} and only recovered from it gradually once near the Island. He also accidentally {{spoiler|used it on his lab assistant/girlfriend, unsticking her in time}}.
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* The Progenitors from ''[[Genius: The Transgression]]'' have a whole transhumanist philosophy centered around this trope.
** The trope is also [[Enforced Trope|enforced]] by the game's [[Karma Meter]]: self-modification is a Transgression, but running risky and dangerous experiments on human test subjects (even willing ones) is a worse one.
* ''[[Warhammer
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* Professor Hojo in ''[[Final Fantasy VII]]''. When the player party (some of its members being his former test subjects) finally confronts him, {{spoiler|he injects himself with [[The Virus]], claiming that he has, once more, succumbed to his desire for knowledge. As you'd expect from the dad of the [[Trope Namer]], he pulls a [[One-Winged Angel]] afterward.}}
* The game ''Dr. Muto'' has one as its protagonist, capable of collecting DNA from various creatures to mutate himself into various beasts.
* Implied in ''[[
* Implied to be what happened in [[Borderlands|Jacob's Cove]] when Dr. Ned, [[Suspiciously Specific Denial|who is totally not Dr. Zed]], began messing with scag DNA. The end result being a [[Zombie Apocalypse]].
* ''[[Portal 2]]'' reveals that Cave Johnson, the lunatic founder of Aperture Science, was not above testing his inventions on himself. This resulted in his death by Conversion Gel (moon dust) poisoning. Somewhat related, when his recruitment of [[Disposable Vagrant|street bums]] as test subjects had less than ideal results, he began encouraging his own employees to test the company's products, which had a negative effect on morale and retention. The next evolution of this seems to have occurred only after his death, with "[[It Got Worse|Bring Your Daughter to Work Day]]".
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[[Category:Tropes On Science and Unscience]]
[[Category:Truth in Television]]
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