Scoob!/Trivia
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- Executive Meddling: Tony Cervone, the film's director, has stated that this was behind the recasting of the characters' voice actors - he wanted to use the characters' original VAs, but Warner Bros. thought it would be better to use an All-Star Cast instead.
- Missing Trailer Scene: The scene from the first trailer where Puppy!Scooby licks Shaggy, and Shaggy licks him back, leading to Scooby saying "Don't do that again," never happens in the film proper.
- The Other Darrin: With the exception of Frank Welker as Scooby, all of the Mystery Inc. members were recast for this film:
- Will Forte plays Shaggy instead of Matthew Lillard.
- Instead of being voiced by Grey DeLisle, Daphne is voiced by Amanda Seyfried.
- Velma is played by Gina Rodriguez rather than Kate Micucci, who has been the voice of Velma since 2016.
- Zac Efron and Ken Jeong respectively replace Welker as the voices of Fred Jones and Dynomutt.
- What Could Have Been: When the idea for this film was originally conceived, it was going to be a hybrid live action/CGI film like the first two theatrical movies and the two Made for TV Movies, before it was decided that this movie would be entirely in CGI.
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