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== Anime & Manga ==
* This is the sub-plot in the anime ''[[Highlander the Search For Vengeance]]'', where Marcus has released a virus over New York to wipe out all of people who haven't conformed to his ancient Roman ideals. The virus only had an 80% kill rate but by the end of the movie he's managed to make a 100% version.
* The blood plague from ''[[
* The 'Monkey Business' virus from ''[[Cowboy Bebop]]''. Fortunately, our intrepid heroes made sure the only victims were [[Hoist by His Own Petard|the eco-terrorists who planned to unleash it in the first place.]]
== Film ==
* The [[Hate Plague]] in ''[[Dead Air (2009
* Similarly, the [[Hate Plague]] in ''[[28 Days Later]]'' (and its sequel ''[[28 Weeks Later|Twenty Eight Weeks Later]]'') was caused by researchers looking for a way to calm down angry persons. It flew the other way. Horribly.
* In ''[[I Am Legend]]'', the infection that wiped out most humans was the result of a supposed cure for cancer that ended up going horribly wrong.
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* In ''[[The Dresden Files]]'' novel ''Death Masks'', creating a magical plague like this is the objective of Nicodemus, using the magical power of [[Public Domain Artifact|the Shroud of Turin]]. Nicodemus isn't doing it for any reason beyond [[For the Evulz|to cause chaos and death]], which he views as its own end.
* In ''Echoes of an Alien Sky'' by ''James Hogan'' settlers from Venus spend much of the novel figuring out where Terrans went, and why they look like them. {{spoiler|Turns out they are descended from Terrans, ones sent away right before the Earth was overwhelmed by a Plague. Even more Horrible when one realizes the virus was meant to be genocidal, and it causes the effects of Zombie Rabies essentially. Even the technique used to get away was so experimental that the Venusians didn't think Terrans had found it yet.}}
* In the ''[[Dune]]'' prequels, there's the Omnius Plague, released by the [[
* David Patneaude's ''Epitaph Road'' has this. It's discovered the plague, Elisha's Bear, that killed many of the men on Earth, was released by a fanatical woman.
* ''[[The Wild Boy]]''-the virus created and released by the Lindauzi. Everyone thought they were humanity's saviors, but later, Ilox found the truth.
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