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* Raquel Applegate of ''[[Wild ARMs 4]]'', {{spoiler|due to suffering from an unknown, incurable disease that's implied to be radiation poisoning}}. This doesn't stop her from being the most powerful character in the game, though it does explain why her HP and speed are so low. {{spoiler|She eventually dies in the [[Distant Finale]] epilogue, having never found a cure for her sickness.}}
** Subverted in ''[[Wild ARMs 5]]'', by the ''same character'', but in a [[The Cameo|cameo]] [[Continuity Nod|appearance]]. Although she still has the cough, the player can go on an obnoxiously long [[Irrelevant Sidequest]] to cure her and give her a happier ending. Ironically, the thing you use is the same cure-all that had no effect on her in ''[[Wild ARMs 4]]''.
* ''[[
* In the manga ''[[Emerging]]'', a heavy cough that sometimes [[Blood From the Mouth|produces blood]] is one of the first signs that a character may have contracted the extremely deadly [[The Plague|mystery illness]] that is spreading across Tokyo.
* Takiko from ''[[Fushigi Yuugi]]'' Genbu Kaiden continuously coughs during her journey. When she's back in the Real World, it's revealed that she {{spoiler|caught the consumption of her late mother}}. Then again, {{spoiler|it's already revealed by Miaka that she originally died at the hand of her father}}.
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