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* [[The Speechless]]: {{spoiler|Lefty, after his first stroke}}.
* [[Tangled Family Tree]]: Cal's family tree looks like this due to all the incest tropes above.
* [[
* [[What Happened to the Mouse?]]: In story, Cal comments that people are probably wondering what happened to Desdemona since she seemingly drops out of the story. {{spoiler|Turns out that she's still alive and has just retreated to her room, and lives long enough to see Cal's new male persona and confess the reason he's the way he is.}}
* [[Wrong Genetic Sex]]: As the result of 5-alpha-reductase deficiency. Genetically, Callie is 46,XY, but lacks the enzyme that converts testosterone to its active form. Thus, he has cryptorchid (undescended) testes, no ovarian or uterine structures, a nonfunctional vaginal pouch, and a microphallus (such that it's repeatedly mistaken for a larger-than-normal clitoris, both by Callie and by several doctors).
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