Throw Momma from the Train/Funny

The classic moment when Owen smacks Larry in the head with a frying pan.

Owen: You LIED to me! (whang!)

Owen's fantasies of killing his mother, especially his bowling fantasy,
Larry's exchange with Momma:

Momma: Who the HELL are you?
Larry: I'm Owen's friend.
Momma: Owen doesn't have any friends!
Larry: That's because he's shy.
Momma: No he's not. He's fat and he's stupid!

After Owen tries to kill her by blowing a trumpet in her ear while she sleeps, she wakes up a moment later and yells, "Holy shit! What a dream I was having! Louis Armstrong was trying to kill me!", followed by the Groin Attack below.
Also:

Momma: Get out of my way you black bastard!!
Larry: What?

Many scenenes, if not all of'em, with Momma involved.

Momma: Owen! Food!
Owen: In a minute, Momma.
Momma: Don't you "In a minute, Momma" me! Get off your fat little ass or I'll break it for you! I want two soft boiled eggs, white toast, and some of that grape jelly god damn it! And don't burn the toast!

Momma: Your friend had an accident, he's dead! You go bowling and leave a corpse to take care of me!
Owen: He's dead?
Momma: See for yourself.
Owen: Larry! My friend, my friend... Larry!
Momma: "My friend! My friend!" You big crybaby. Go bury him in the yard before he stinks up the place.

Momma: Owen loves his Momma, Owen loves his Momma, Owen loves his Momma...

(after seeing Larry falling down in the basement)
Momma: Pain in the ass !

When Larry and Owen are joking about his trouble to start his book ("The night was moist"), Momma pipes in with the perfect opening ("The night was sultry"), which finally breaks Larry, who quietly declares he's going to kill the bitch.
Mrs. Hazeltine's story. This goes double for writers.
When Beth visits Larry's class, Pinsky, who's book project is "100 Girls I'd Like to Pork", asks her her name. When he's told, he says thoughtfully, "Beth, eh?" Larry gives him a Death Glare and warns, "Don't even think about it."