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Compare [[Tampering with Food and Drink]], which is at least normally intended as a (deadly) prank.
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== [[Anime]] and [[Manga]] ==
* In ''[[Birdy the Mighty]]'', this was Seichiro Hikawa's plan for the people of Tokyo, to turn them into "retro soldiers" by tainting the city's water supply with serum [http://www.youtube.com/watch?v=kxFqMG_OSNs starting at 4:27].
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* A Captain America arc, during Cap's "The Captain" phase, had Madam Hydra/Viper putting drugs into Washington D.C.'s water supply. What did said drugs do? Turned everyone who drank the water into half-human, half-snake hybrids.
== [[Film]]
* In ''[[Toy Story (franchise)|Toy Story]]'', one of Woody's quotes that play when someone pulls his string is "Somebody's poisoned the waterhole!"
* In ''[[Erin Brockovich]]'', PG&E tries to cover up the fact that they were poisoning the groundwater of the town Hinkley, California with Hexavalent Chromium, which resulted in most of the town suffering from illness and cancer.
* The plot of the old action flick ''Never Too Young To Die'' involves the hero trying to stop a bad guy played by Gene Simmons from poisoning the water supply.
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== [[Literature]] ==
* ''Tribesmen of [[Gor]]'' [[Fantasy Counterpart Culture]] to
* Donald J. Sobol's ''Secret Agents Four''. A criminal organization named Cobra plans to put a drug in the city of Miami's water supply. The drug causes the victim to relive the last 24 hours, rendering them helpless.
* "When the Past Went Away" by [[Robert Silverberg]]: Amnesia-inducing drugs are dumped in a city's water supply, leaving everybody in the city with no memory of who they are.
* Defied by Alastor Moody in his first appearance in ''[[Harry Potter]]'': the known paranoid drinks only from his canteen, but {{spoiler|it's a subversion as this conveniently allows an
* In ''The First Virtue'', part of [[Star Trek: Stargazer]], a fanatical Cordracite poisons her city's water supply in order to escalate a conflict with another race, assuming they'll be blamed.
* In ''[[
* The "next stage of testing" that leads to the climax of ''[[The Butterfly Kid]]'' is the aliens' plan to dose the New York City reservoir with the Reality Pill in liquid form.
== [[Live
* Played with in an episode of ''[[Star Trek: The Next Generation]]'' where Data - who has amnesia and doesn't know about his own history or Starfleet - is accused of poisoning a well in the village he's living in, but he's really trying to cure them of radiation poisoning by putting the cure in the drinking water.
* In ''[[The X-Files]]'' episode "Anasazi", [[The Syndicate]] puts LSD into Mulder's water supply, causing erratic behavior that discredits both him and the case he is currently following. And since it wasn't just Mulder's water supply, but his entire apartment building's, it also caused at least one murder there.
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