Determinator/Web Original

Tifa Lockheart in the fan film series Dead Fantasy is an insanely awesome representation of this trope. Throughout five shorts, she has been slapped with an axe capable of downing a skyscraper, beaten to a bleeding pulp, which involved literally having the Materia knocked out of her, jumped onto a train, been slashed quite a few times, filled with arrows like it was target practice, stabbed through the arm, and chained up by kusarigama. It takes Hayate's intervention to finally stop her.
The Protectors of the Plot Continuum. They have been led for a time by the Big Bad, faced a never-ending deluge of badfic, and been driven out of their headquarters by The Plague; however, they never stop the fight against Mary Sues.
LordKaT is the brain behind the Until We Win videos, where he plays obscenely difficult video games and does not stop until he does in fact beat it.
As of today (12th April 2011) 'Card Games FTW' - the youtube account of Little Kuriboh - is back up after its fifth banning.
In a Meta sense, see the page picture up there? It went through the third biggest Image Pickin Forum with the crowner with the most number of images EVER. It was open for months (IIRC) without any examples with above zero points. But guess what, we made it, and there's the picture. The people who participated in the forum are all Determinators.
The New Avengers as a whole, and several other characters as well, in Marvels RPG.
The Nostalgia Chick lives in either LA or New York City. She will run from either of these places to Virginia and Chicago to stalk and fight (and chloroform), respectively.
On that note, The Nostalgia Critic had run from Chicago to Pennsylvania for a brawl with the Nerd.
In The Gamers Alliance, Leopold and Orestes stop at nothing to get the job done.