• Acting for Two: Jaleel White played Steve Urkel, Myrtle Urkel, and Stefan Urquelle (when Steve accidentally clones himself and have one be permanently Stefan). He even got to be a one-off criminal cousin. All of that, in addition to the transformation chamber, was to allow Jaleel White some opportunity to not keep up the squeaky Steve voice, which got harder and harder as he grew up. This was also done because White was a talented character actor and impressionist. His Bruce Lee is actually quite good, and reportedly one of his favorite roles.
  • Channel Hop: From ABC to CBS for its last season.
  • Contest Winner Cameo: The four children picked to be Steve and Laura's children for one of Carl Winslow's nightmares.
  • The Danza: Maxine Johnson was played by Cherie Johnson.
  • Dawson Casting: The late Michelle Thomas was in her mid twenties when cast as Myra Monkhouse. She was actually 7-8 years older than the other teen actors.
  • Hey, It's That Guy!:
    • One episode features Urkel facing off against a group of bullies lead by Jason David Frank, whom most children of the 90s know as Tommy Oliver, the breakout star of the Power Rangers franchise.
    • Baby Santana has a crush on Richie.
    • Richie and Eddie are on The Young and the Restless.
    • Harriette is Suga Mama.
      • With Grandma Winslow's personality.
    • Orlando Brown would later play another Eddie...
    • A young Charles Gunn hits on Maxine before getting chased away by Waldo.
    • Angela got shot by female thugs over a pair of new sneakers.
    • Maxine (Laura's friend and Waldo's girlfriend) was Punky Brewster's Black Best Friend.
  • I Am Not Urkel: This series pretty much killed any shot at Jaleel being taken seriously as an actor, outside voicework. This is slightly subverted as White doesn't resent his most famous role and has fond memories of the series.