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• Actor Allusion:
  • Dr. Maddox, played by Courteney Cox, makes fun of Dr. Perry Cox's last name.
  • It is revealed that The Janitor was in The Fugitive. Neil Flynn, who plays The Janitor, really did play that role.
  • A very dark one - you know that episode where Hooch threatens to run somebody over? Guess which actor actually had fatally run someone over in the early nineties. Go on. Guess.
  • In "My Last Chance", JD is watching Sixteen Candles (starring Molly Ringwald) with Dr. Molly Clock and internally exclaims "God bless Mollys everywhere!". That particular episode featured an ambulance driver played by Molly Shannon.
  • In "My Last Words", Turk tells a patient about how he used to be a football safety in college. Guess where the character played by Donald Faison, who played Turk, ends up playing in the movie Remember the Titans? He starts out on offence but is moved to safety.
  • In "My Unicorn", JD finds a patients son that has a problem with his name that "makes him sound like a old man." Did I mention he's played by Mathew Perry who also played a character with a name that "makes him sound like a girl."
• Channel Hop: Moved to ABC in the eighth season. Interestingly enough, the show was ABC produced anyway but aired on NBC for some reason. This was because the show predated a change in what incentives each network looked for in a show. In 2001, it was more common for networks to buy shows from each others' production companies (though usually only after the network that technically produced it passed). This is true in the case of Scrubs: ABC originally declined to air the show), because the only way to profit off a show was through the network charging for commercial time (how much they charged was based on ratings), and an eventual syndication deal, through which the production company and the broadcast network would split the profits. By the mid-00's, broadcast ratings were down across the board (meaning networks couldn't charge as much for ads), but the DVD and online markets were rising. Only production companies made money from the DVD and online download sales. This was the tipping point at which networks started to only broadcast shows made by their own production companies, because then if the show didn't have great ratings but had a strong cult audience who would buy the DVD's, the parent company of both the network and the production company would still profit.
• Hey, It's That Guy!: Turk used to play football.
  • Doctor Cox used to work in an office.
  • JD used to hang around with The Baby Sitters Club.
  • The Janitor wasn't always a janitor
    • Even Lampshaded in one episode when JD happens to be watching The Fugitive.
  • Elliot is a laser tattoo removal surgeon, and nearly married an architect.
• Romance on the Set: The stunt actors for JD and Elliot met for the very first time filming the bungee jumping scene in the second season. They later got married.
  • The cast and crew even helped with the proposal.
• What Could Have Been: Don Lamb could have ended up as JD.
  • Neil Flynn auditioned for Dr. Cox originally.