• Actor Allusion:
    • When Sean Maher shows up as an antagonist to Jayne - ahem, Jane - he says the speech that the Victim of the Week was going to give was about River rafting...
    • Also, since Lisbon (Robin Tunney) is best known for being Sarah in The Craft, the whole episode "Red Rum" had a bit of this. And Lisbon's crazy looked remarkably Tourette's-ish, Tunney's other major role being the lead in Niagara, Niagara.
    • Jane commenting "You should have seen me ten years ago" might be a Shout-Out to Simon Baker's 2001 drama series, The Guardian.
  • Directed by Cast Member: When Simon Baker directs episodes, prepare for your darkest episodes ever, both in lighting and storyline.
    • "Red Moon" in Season 3, an extremely well-done Red John Myth Arc episode.
    • "Blinking Red Light" in Season 4, where Jane plays off its coldest Batman Gambit in the series to prevail over the killer. It also reopens Red John Myth Arc.
  • Fake American: Jane is played by Simon Baker, an Australian, while Rigsby is played by Owain Yeoman from Wales.
  • Hey, It's That Guy!: The appearances of the following people:
    • Stacie Leah Rippy, from True Blood (where she was a vampire), a one-time bit-part actor, now getting major roles.
    • Also, Jessica from True Blood has a small role in the episode "Red Brick and Ivy".
    • Jaime Murray, from Hustle.
    • Tina Hobley, although apparently she went uncredited in one episode. Or so Popcultural Osmosis would have you believe...
    • For that matter, Tim Kang was previously best known as "that Asian guy" in the commercials for Cingular, Dairy Queen and Home Depot.
    • HRG is the husband of a murder victim.
    • Bobby Singer shows up as the owner of a stables.
    • Christina Cox, of Nikki & Nora cult fame, turns up as a girlfriend in the same episode.
    • John Billingsley (Dr. Phlox) and Connor Trineer (Charles "Trip" Tucker) guest-starred together in the 11/18 episode "Red Moon".
      • And Hoshi consulted with the CBI (Season 3 Episode 12).
    • The show is loaded with former 24 cast members. Just a couple examples are Gregory Itzen (Charles Logan) as Virgil Minelli and Leslie Hope (Teri Bauer) as Kristina Frye.
    • Morena Baccarin (a.k.a. Anna, Inara, Adria) is a matchmaker, recently widowed, in the episode "Every Rose Has Its Thorn".
    • Josh Lyman is Red John.
    • Christopher Judge (Teal'c) plays a casino's security chief. Jay Avocone (Maj. Charles Kawalsky) is his boss.
    • Simon Tam is a mayor's aide moonlighting as an environmental terrorist.
  • Real Life Relative: Simon Baker's, Tim Kang's and Owain Yeoman's wives have appeared on the show.