Five-Man Band/Video Games/A-C

Ace Attorney (During "Trials & Tribulations" final case.)

The Hero	Phoenix Wright
The Lancer	Maya Fey
The Smart Guy	Miles Edgeworth
Tagalong Kid	Pearl Fey
The Big Guy	Dick Gumshoe
Sixth Ranger	Franziska von Karma

Ace Attorney Investigations: Miles Edgeworth (During the final case.)

The Hero	Miles Edgeworth
The Lancer	Dick Gumshoe
The Chick	Kay Faraday
The Smart Girl	Franziska von Karma
The Big Guy	Shi-Long Lang

Agarest Senki (Generation 1)

The Hero	Leonhardt Raglen
The Lancer	Zerva and Fyuria
The Big Guy	Borgnine
The Smart Guy	Dyshana
The Chick(s)	Vira-Lorr and Luana
Tagalong Kid	Ellis
Sixth Ranger	Winfield and Elaine

Agarest Senki (Generation 5. This is going to be tough.)

The Hero	Rex Raglen
The Lancer	Winfield, Zerva, Alberti, and Dyshana
The Big Guy	Borgnine, Arbol,and Ganz
Tagalong Kid	Qua and Fer
The Chick(s)	Ellis (Team Mom), Vira-Lorr, Sharona, Reverie, and Plum
Sixth Ranger	Beatrice, Murmina and Vashtor if you redeem him

All of them could technically be The Mentor to Rex. With the exception of the last three.

Age of Mythology

The Hero	Arkantos
The Lancer	Chiron, sometimes Ajax or Amanra
The Big Guy	Ajax
The Smart Guy	Chiron
The Chick	Regenleif
Tagalong Kids	Brokk and Etri

Albion

The Hero	Tom
The Lancer	Drirr (and occasionally Joe)
The Big Guy	Siobhan
The Smart Guy	Rainer, later Harriet
The Chick(s)	Sira and Mellthas
Sixth Ranger Traitor	Khunag

Anachronox

The Hero	Sly Boots
The Lancer(s)	PAL and Stiletto
The Big Guy	Paco
The Smart Guy(s)	Grumpos and Rho
The Chick	Fatima, Democratus (also fits as "the peaceful one")
Sixth Ranger Traitor	Grumpos - the bastard plays a sly gambit without you even knowing, complete with pulling a Face Heel Turn, to summon the final boss.

Angry Birds

The Hero	Red Bird
The Lancer	Yellow Bird
The Smart Guy	White Bird
The Big Guy	Black Bird
The Chick	Blue Bird
Sixth Ranger	Green Bird, Big Red Bird, Orange Bird, Blu, and Jewel
Big Good	The Eagle

Ape Escape series - The Protagonists

The Hero	Spike
The Lancer	Jake
The Big Guy	Natalie
The Smart Guy	Helga (sometimes The Chick)
The Chick	Casi (sometimes The Smart Guy)
Mentor Archetype	The Professor, later Aki
Sixth Ranger	Jimmy, later Kei and Yumi
Sixth Ranger Traitor	Tomoki
Team Pet	Pipotchi (Jimmy's pet)

Note: Pipo Monkeys are becoming a Team Pets in Pumped & Primed and later The Pipotron Brothers (especially in the anime), although they can be Sixth Ranger Traitors sometimes.

Ape Escape series - The Freaky Monkey Five

The Hero	Red Monkey
The Lancer	Blue Monkey
The Big Guy	Yellow Monkey
The Smart Guy	White Monkey
The Chick	Pink Monkey

Note: Sometimes, they can be Five-Bad Band (Red Monkey is The Big Bad, Blue Monkey is The Dragon, Yellow Monkey is The Brute, White Monkey is The Evil Genius, and Pink Monkey is The Dark Chick).

Arcana Heart

The Hero	Heart
The Lancer	Saki (she often disagrees with Heart, but they're the best of friends)
The Big Guy	Maori (who has the Earth arcana)
The Smart Guy	Yoriko
The Chick	Lilica
Sixth Ranger	Fiona (may be one in the sequel)

Armored Core For Answer - Carpals Counter Occupation Team

The Hero	Wynne D. Fanchon
The Lancer	Ostdarva
The Big Guy	Roadie
The Smart Guy	Kasumi Sumrika
The Chick	Lilium Wolcott

Baldurs Gate

The Hero	CHARNAME
The Lancer	Jaheira/Imoen
The Big Guy	Minsc
The Smart Guy	Dynaheir
The Chick	Khalid/Imoen
Team Pet	Boo

Baten Kaitos: Eternal Wings and the Lost Ocean

The Hero	Kalas (most of the time), Xelha (when Kalas isn't part of the group)
The Lancer	Gibari (also a classic Big Guy)
The Big Guy	Savyna
The Smart Guy	Lyude
The Chick	Xelha, ~~Mizuti~~ The Great Mizuti

Battalion Wars (COs fight Xylvania)

The Hero	You
The Lancer	Nova
The Big Guy	Herman
The Smart Guy	Austin
The Chick	Betty

Battalion Wars - Infantry

The Hero	Grunts
The Lancer	Assault Vets
The Big Guy	Bazooka and Flame Vets
The Smart Guy	Mortar Vets
The Chick	Anti Air Vets

Blaz Blue

The Hero	Ragna the Bloodedge
The Lancer	Jin Kisaragi
The Big Guy	Hakumen
The Smart Guy	Rachel Alucard
The Chick	Noel Vermillion

Blood II: The Chosen

The Hero	Caleb
The Lancer	Ophelia - doubles as The Chick
The Big Guy	Gabriella
The Smart Guy	Ishmael

Blue Dragon

The Hero	Shu
The Lancer	Zola
The Big Guy	Marumaro
The Smart Guy	Jiro
The Chick	Kluke

Borderlands

The Hero	Roland (Soldier)
The Lancer	Mordecai (Hunter)
The Big Guy	Brick (Berserker)
The Smart Guy	Lilith (Siren)

Breath of Fire III

The Hero	Ryu
The Lancer	Rei
The Big Guy	Garr
The Smart Guy	Momo
The Chick	Nina
Team Pet	Peco

Breath of Fire IV

The Hero	Ryu
The Lancer	Cray
The Big Guy	Scias
The Smart Guy/Robot Buddy	Ershin
The Chick	Nina
Sixth Ranger	Ursula

Bully (Last mission only)

The Hero	Jimmy
The Lancer	Edgar
The Big Guy	Russell
The Smart Guy	Petey
The Chick	Zoe

Call of Duty Modern Warfare 2 Task Force 141

The Hero	Sgt. Gary "Roach" Sanderson
The Lancer/The Smart Guy	Simon "Ghost" Riley
The Big Guy	Captain "Soap" MacTavish
Tagalong Kid	Nikolai
The Mentor	Captain Price
Big Brother Mentor	General Shepherd until his betrayal

Cars Mater-national

The Hero	Giovanni
The Lancer	Otto
The Smart Guy	Koji
The Big Guy	Gudmund
The Chick	Emma
Sixth Ranger	Lightning McQueen and Mater

Catherine: Vincent and his friends

The Hero	Vincent
The Lancer	Orlando
The Smart Guy	Jonny
The Big Guy	Toby
The Chick	Erica

City of Heroes

The Hero	Statesman
The Lancer	Manticore or Synapse
The Smart Guy	Positron
The Big Guy	Citadel
The Chick	Sister Psyche

City of Heroes character archetypes

The Hero	The Scrapper (good all-round offense and defense)
The Lancer	The Blaster (a Glass Cannon compared to the Scrapper's more balanced approach)
The Big Guy	The Tanker (with his high defense and HP)
The Smart Guy	The Controller (for debuffing and crowd-control)
The Chick	The Defender (for healing/buffing and damage)
The Sixth Ranger	Kheldians (added later, only available after getting another hero to level 20)

Clive Barkers Jericho

The Hero	Captain Devin Ross
The Lancer	Billie Church and Abigail Black
The Big Guy	Frank Delgado
The Smart Guy	Simone Cole and Xavier Jones
The Chick	Father Paul Rawlings

The ClueFinders

The Hero / The Chick	Joni Savage
The Lancer	Santiago Rivera
The Big Guy	Owen Lam
The Smart Guy	Leslie Clark
Team Pet	LapTrap, Socrates

Command and Conquer Renegade

The Hero	Nick "Havoc" Parker
The Big Guy	Nigel "Gunner" Grant
The Chick	Shai "Hotwire" Aviv
The Quiet One	Dariel "Deadeye" MacInnis
The Lancer	Erich "Patch" Wulfe
Tagalong Kid	Sydney Mobius